Results 11 to 20 of about 1,519,611 (347)
European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke
European Stroke Journal, 2021 Intravenous thrombolysis is the only approved systemic reperfusion treatment for patients with acute ischaemic stroke. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist physicians in their clinical ...E. Berge, W. Whiteley, H. Audebert, G. M. D. Marchis, Ana Catarina Fonseca, C. Padiglioni, N. D. L. Ossa, D. Strbian, G. Tsivgoulis, G. Turc +9 moresemanticscholar +1 more sourceEffect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial.
Journal of the American Medical Association (JAMA), 2021 Importance
Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy in patients with acute large vessel occlusion stroke is unclear.Kentaro Suzuki, Y. Matsumaru, M. Takeuchi, M. Morimoto, R. Kanazawa, Y. Takayama, Y. Kamiya, Keigo Shigeta, S. Okubo, Mikito Hayakawa, Norihiro Ishii, Y. Koguchi, T. Takigawa, M. Inoue, H. Naito, T. Ota, T. Hirano, N. Kato, T. Ueda, Y. Iguchi, K. Akaji, W. Tsuruta, K. Miki, S. Fujimoto, T. Higashida, Mitsuhiro Iwasaki, Junya Aoki, Y. Nishiyama, T. Otsuka, K. Kimura +29 moresemanticscholar +1 more sourceEffect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial.
Journal of the American Medical Association (JAMA), 2021 Importance
For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared with intravenous thrombolysis plus endovascular treatment (standard treatment) can achieve similar functional outcomes.W. Zi, Zhongming Qiu, Fengli Li, Hongfei Sang, Deping Wu, W. Luo, Shuai Liu, Junjie Yuan, Jiaxing Song, Zhonghua Shi, Wenguo Huang, Min Zhang, Wen-hua Liu, Zhangbao Guo, Tao Qiu, Qiang Shi, P. Zhou, Li Wang, Xinmin Fu, Shudong Liu, Shi-quan Yang, Shuai Zhang, Zhiming Zhou, Xianjun Huang, Yan Wang, Jun Luo, Yongjie Bai, Min Zhang, Youlin Wu, Guoyong Zeng, Y. Wan, C. Wen, Hongbin Wen, Wentong Ling, Zhuo Chen, M. Peng, Zhibing Ai, F. Guo, Huagang Li, Jing Guo, Hai-tao Guan, Zhiyi Wang, Yong Liu, J. Pu, Zhen Wang, Hansheng Liu, Luming Chen, Jiacheng Huang, Guoqiang Yang, Zi-li Gong, Jie Shuai, R. Nogueira, Qingwu Yang +52 moresemanticscholar +1 more sourceA Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke.
New England Journal of Medicine, 2021 BACKGROUND
The value of administering intravenous alteplase before endovascular treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian populations.N. LeCouffe, M. Kappelhof, K. Treurniet, L. Rinkel, A. Bruggeman, O. Berkhemer, L. Wolff, H. van Voorst, M. Tolhuisen, D. Dippel, A. van der Lugt, A. V. van Es, J. Boiten, G. J. Lycklama à Nijeholt, K. Keizer, R. Gons, Lonneke S. F. Yo, R. V. van Oostenbrugge, W. V. van Zwam, B. Roozenbeek, H. B. van der Worp, Rob H. Lo, I. R. van den Wijngaard, I. D. de Ridder, V. Costalat, C. Arquizan, R. Lemmens, J. Demeestere, J. Hofmeijer, Jasper M. Martens, W. Schonewille, J. Vos, M. Uyttenboogaart, R. Bokkers, J. V. van Tuijl, Hans G. Kortman, F. Schreuder, H. Boogaarts, K. D. de Laat, L. V. van Dijk, H. D. den Hertog, B. V. van Hasselt, P. Brouwers, Tomas Bulut, M. Remmers, A. V. van Norden, Farshad Imani, A. Rozeman, O. Elgersma, P. Desfontaines, D. Brisbois, Y. Samson, F. Clarençon, G. M. Krietemeijer, A. Postma, P. van Doormaal, R. van den Berg, A. van der Hoorn, L. Beenen, D. Nieboer, H. Lingsma, B. Emmer, J. Coutinho, C. Majoie, Y. Roos +64 moresemanticscholar +1 more sourceRestriction of Intravenous Fluid in ICU Patients with Septic Shock.
New England Journal of Medicine, 2022 BACKGROUND
Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU).
METHODS
In this international, randomized T. Meyhoff, P. B. Hjortrup, J. Wetterslev, Praleene Sivapalan, J. H. Laake, M. Cronhjort, Stephan M. Jakob, Maurizio Cecconi, Marek Nalos, M. Ostermann, Manu L. N. G. Malbrain, V. Pettilä, M. H. Møller, M. N. Kjær, Theis Lange, Christian Overgaard-Steensen, B. Brand, Marie Winther-Olesen, Jonathan O White, Lars Quist, B. Westergaard, A. B. Jonsson, C. J. Hjortsø, Nick Meier, T. S. Jensen, Janus Engstrøm, Lars Nebrich, N. Andersen-Ranberg, Jacob V Jensen, Neeliya A Joseph, Lone M. Poulsen, L. S. Herløv, C. Sølling, Susan K Pedersen, Kurt K Knudsen, Therese S Straarup, M. Vang, H. Bundgaard, B. Rasmussen, Søren R Aagaard, T. Hildebrandt, L. Russell, M. Bestle, Martin Schønemann-Lund, A. C. Brøchner, Claes F Elvander, Søren K L Hoffmann, M. L. Rasmussen, Y. K. Martin, F. F. Friberg, Herman Seter, T. N. Aslam, Sigrid Ådnøy, Philipp Seidel, Kristian Strand, Bror Johnstad, E. Joelsson-Alm, Jens Christensen, Christian Ahlstedt, C. Pfortmueller, M. Siegemund, Massimiliano Greco, J. Raděj, M. Kříž, Doug Gould, Kathy M Rowan, P. Mouncey, A. Perner +67 moresemanticscholar +1 more sourceEndovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke.
New England Journal of Medicine, 2020 BACKGROUND
In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy.Pengfei Yang, Yongwei Zhang, Lei Zhang, Yongxin Zhang, K. Treurniet, Wenhuo Chen, Ya Peng, Hongxing Han, Jiyue Wang, Shouchun Wang, Congguo Yin, Sheng Liu, Peng Wang, Q. Fang, Hongchao Shi, Jianhong Yang, C. Wen, Conghui Li, Changchun Jiang, Jun Sun, X. Yue, Min Lou, Meng Zhang, Hansheng Shu, Dianjing Sun, Huizhi Liang, Tong Li, F. Guo, Kaifu Ke, Hai-cheng Yuan, Guoping Wang, Weimin Yang, Huaizhang Shi, Tianxiao Li, Zifu Li, P. Xing, Ping Zhang, Y. Zhou, Hao Wang, Yi Xu, Qinghai Huang, Tao Wu, R. Zhao, Qiang Li, Yibin Fang, Laixing Wang, Jianping Lu, Yansheng Li, Jianhui Fu, Xihua Zhong, Yongjun Wang, Longde Wang, M. Goyal, D. Dippel, B. Hong, Benqiang Deng, Y. Roos, C. Majoie, Jianmin Liu +58 moresemanticscholar +1 more sourcePrevention of tuberculosis in macaques after intravenous BCG immunization
Nature, 2020 Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of ...P. Darrah, Joseph J Zeppa, Pauline Maiello, Joshua A. Hackney, M. Wadsworth, T. Hughes, S. Pokkali, P. Swanson, N. Grant, Mark A. Rodgers, Megha Kamath, Chelsea M. Causgrove, Dominick J. Laddy, A. Bonavia, D. Casimiro, P. Lin, E. Klein, Alexander G. White, C. Scanga, A. Shalek, M. Roederer, J. Flynn, R. Seder +22 moresemanticscholar +1 more sourceStent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.
New England Journal of Medicine, 2015 BACKGROUND
Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone.J. Saver, M. Goyal, A. Bonafe, H. Diener, E. Levy, V. Pereira, G. Albers, C. Cognard, D. Cohen, W. Hacke, O. Jansen, T. Jovin, H. Mattle, R. Nogueira, A. Siddiqui, D. Yavagal, B. Baxter, T. Devlin, D. Lopes, V. Reddy, R. du Mesnil de Rochemont, O. Singer, R. Jahan +22 moresemanticscholar +1 more source
