Results 41 to 50 of about 1,519,611 (347)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway

Frontiers in Pharmacology
Cognitive impairments following post-stroke significantly hinder neurological recovery and exacerbate patient morbidity, underscoring urgent need for effective therapeutic strategies. Vortioxetine (VTX), a prominent Selective Serotonin Reuptake Inhibitor
Ziqiang Dong, Zhihui Dong, Lili Xu, Jinfeng Zhang, Lin Li, Rongjuan Wang, Xiaoyan Huang, Zhengqiang Zou, Zhengqiang Zou, Zhengqiang Zou, Zhengqiang Zou   +10 more
doaj   +1 more source

First-in-human pilot trial of combined intracoronary and intravenous mesenchymal stem cell therapy in acute myocardial infarction

Frontiers in Cardiovascular Medicine, 2022
BackgroundAcute ST-elevation myocardial infarction (STEMI) elicits a robust cardiomyocyte death and inflammatory responses despite timely revascularization.ObjectivesThis phase 1, open-label, single-arm, first-in-human study aimed to assess the safety ...
Lien-Cheng Hsiao, Lien-Cheng Hsiao, Yen-Nien Lin, Yen-Nien Lin, Woei-Cherng Shyu, Woei-Cherng Shyu, Ming Ho, Chiung-Ray Lu, Shih-Sheng Chang, Shih-Sheng Chang, Yu-Chen Wang, Jan-Yow Chen, Jan-Yow Chen, Shang-Yeh Lu, Mei-Yao Wu, Mei-Yao Wu, Keng-Yuan Li, Yu-Kai Lin, Wen-Yih I. Tseng, Mao-Yuan Su, Chin-Ting Hsu, Cheng-Kang Tsai, Lu-Ting Chiu, Chien-Lin Chen, Cheng-Li Lin, Cheng-Li Lin, Kai-Chieh Hu, Kai-Chieh Hu, Der-Yang Cho, Der-Yang Cho, Chang-Hai Tsai, Kuan-Cheng Chang, Kuan-Cheng Chang, Long-Bin Jeng, Long-Bin Jeng   +34 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

Circulation, 1987
Intravenous administration of 80 mg of recombinant tissue plasminogen activator (rt-PA, 40, 20, and 20 mg in successive hours) and streptokinase (SK, 1.5 million units over 1 hr) was compared in a double-blind, randomized trial in 290 patients with ...
J. Chesebro, G. Knatterud, R. Roberts, J. Borer, L. Cohen, J. Dalen, H. Dodge, C. Francis, D. Hillis, P. Ludbrook   +9 more
semanticscholar   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

Critical Care, 2019
BackgroundIntravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-
J. Hippensteel, R. Uchimido, P. Tyler, R. Burke, Xiaorui Han, Fuming Zhang, S. McMurtry, James F. Colbert, C. Lindsell, D. Angus, J. Kellum, D. Yealy, R. Linhardt, N. Shapiro, E. Schmidt   +14 more
semanticscholar   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital

Jurnal Manajemen dan Pelayanan Farmasi, 2019
Drugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability.
Ardhanarishwari Umi Salamah, Fita Rahmawati, Fivy Kurniawati   +2 more
doaj   +1 more source

Guidelines for the safe practice of total intravenous anaesthesia (TIVA)

Anaesthesia, 2018
Guidelines are presented for safe practice in the use of intravenous drug infusions for general anaesthesia. When maintenance of general anaesthesia is by intravenous infusion, this is referred to as total intravenous anaesthesia.
A. Nimmo, A. Absalom, O. Bagshaw, A. Biswas, T. Cook, A. Costello, S. Grimes, D. Mulvey, S. Shinde, T. Whitehouse, M. Wiles   +10 more
semanticscholar   +1 more source