Results 91 to 100 of about 39,284 (377)

From Molecule to Aggregate: Designing AIE Nanocrystals for Low‐Power Backward Third‐Harmonic Generation Angiography

Advanced Materials, EarlyView.
An organic BTHG agent called OTBP with prominent crystallinity is developed. The resonant absorption at 433 nm and prominent crystallinity of OTBP enhance its BTHG efficiency when excited by a 1300 nm femtosecond laser. Tuning the size of OTBP nanocrystals based on Mie scattering theory successfully enables them to achieve high‐contrast muti‐organ ...
Lidong Du, Hanchen Shen, Changhuo Xu, Xinyan Zhu, Bingnan Wang, Qingqing Zhou, Chunxi Liu, Herman H. Y. Sung, Ryan T. K. Kwok, Jacky W. Y. Lam, Quan Zhou, Tzu‐Ming Liu, Ben Zhong Tang   +12 more
wiley   +1 more source

Effects of anesthetics on development of gynecological cancer

Frontiers in Cell and Developmental Biology
Gynecological cancers remain a leading cause of cancer among female patients, and surgery continues to be the primary therapeutic approach. Anesthesia is an indispensable component of perioperative period.
Yingxiang Cheng, Yunzhi Wu, Lingzhong Xu
doaj   +1 more source

Macaque's Cortical Functional Connectivity Dynamics at the Onset of Propofol-Induced Anesthesia [PDF]

arXiv, 2021
Propofol, when administered for general anesthesia, induces oscillatory dynamic brain states that are thought to underlie the drug's pharmacological effects. Despite the elucidation of propofol's mechanisms of action at the molecular level, its effects on neural circuits and overall cortical functioning, which eventually lead to unconsciousness, are ...
arxiv  

Recent advances in intravenous anesthesia and anesthetics

F1000Research, 2018
Anesthesiology, as a field, has made promising advances in the discovery of novel, safe, effective, and efficient methods to deliver care. This review explores refinement in the technology of soft drug development, unique anesthetic delivery systems, and recent drug and device failures.
Mohamed Mahmoud, Keira P. Mason
openaire   +3 more sources

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance

Advanced Therapeutics, EarlyView.
Antimicrobial resistance necessitates the development of new antibiotics with “resistance‐breaking” properties. In this study, conjugation of polycationic peptides is proven to represent a versatile strategy for the fast and affordable reactivation of daptomycin.
Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein, Karel D. Klika, Christian Kleist, Julia Werner, Cornelius Domhan, Mara Bingel, Anna Müller, Marvin Rausch, Stefan Zimmermann, Knut Ohlsen, Uwe Haberkorn, Marcus Koch, Markus Bischoff, Tanja Schneider, Rolf Müller, Jennifer Herrmann, Walter Mier, Philipp Uhl   +21 more
wiley   +1 more source

Combined implanted central venous access and cortical recording electrode array in freely behaving mice

MethodsX, 2021
Establishing a long-lasting, functioning venous access in a non-anesthetized mouse is very challenging at least. Since we needed a reliable venous access to titrate intravenous anesthetics, we refined and combined previously described methods.
David Peter Obert, David Killing, Tom Happe, Alp Altunkaya, Gerhard Schneider, Matthias Kreuzer, Thomas Fenzl   +6 more
doaj  

Short-term one-lung ventilation does not influence local inflammatory cytokine response after lung resection [PDF]

, 2018
Background: One-lung ventilation (OLV) is a ventilation procedure used for pulmonary resection which may results in lung injury. The aim of this study was to evaluate the local inflammatory cytokine response from the dependent lung after OLV and its ...
Andreetti, Claudio, Borro, Marina, Cipolla, Fabiola, Defraia, Veronica, Fiorelli, Silvia, Ibrahim, Mohsen, Massullo, Domenico., Menna, Cecilia, Rendina, Erino Angelo, Rocco, Monica, Simmaco, Maurizio   +10 more
core   +1 more source

CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression

Advanced Science, EarlyView.
This study elucidates the crosstalk between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer stem cells (ATCSCs). The findings reveal that CCL20 from THP‐1‐M2 activates the IRAK‐1/NF‐κB1/2 pathway in ATCSCs, thereby enhancing CXCL5 secretion.
Qi Liu, Yan Wang, Mingyuan Song, Jiapeng Huang, Jinyuan Shi, Wei Sun, Xiaoyu Ji, Yuang Chang, Bing Ma, Ping Zhang, Yuanyuan Yan, Hao Zhang   +11 more
wiley   +1 more source

Mechanism of Anesthetic Action: Oxygen Pathway Perturbation Hypothesis [PDF]

Medical Hypothese (2001) 57(5): 619-627., 2001
Although more than 150 years have past since the discovery of general anesthetics, how they precisely work remains a mystery. We propose a novel unitary mechanism of general anesthesia verifiable by experiments. In the proposed mechanism, general anesthetics perturb oxygen pathways in both membranes and oxygen-utilizing proteins such that the ...
arxiv