Common anesthetic molecules prefer to partition in liquid disorder phase domain in a composite multicomponent membrane [PDF]
Phys. Rev. E 98, 012409 (2018), 2018 Despite a vast clinical application of anesthetics, the molecular level of understanding of general anesthesia is far from our reach. Using atomistic molecular dynamics simulation, we study the effects of common anesthetics: ethanol, chloroform and methanol in the fully hydrated symmetric multicomponent lipid bilayer membrane comprising of an ...
arxiv +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The degree of hepatic ischemia-reperfusion injury (HIRI) is highly relevant to the incidence of postoperative liver failure and mortality.
Jiayu Feng +5 more
doaj +1 more source
Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial [PDF]
Korean Journal of Anesthesiology, 2021 Background Dexmedetomidine, an alpha-2 agonist, has been used for attenuation of hemodynamic response to laryngoscopy but not through the nebulized route.
Satyajeet Misra +5 more
doaj +1 more source
Membrane Nanodomains Homeostasis During Propofol Anesthesia as Function of Dosage and Temperature [PDF]
, 2020 Some anesthetics bind and potentiate gamma-aminobutyric-acid-type receptors, but no universal mechanism for general anesthesia is known. Furthermore, often encountered complications such as anesthesia induced amnesia are not understood. General anesthetics are hydrophobic molecules easily dissolving into lipid bilayers.
arxiv +1 more source
Edge AI-Based Vein Detector for Efficient Venipuncture in the Antecubital Fossa [PDF]
, 2023 Assessing the condition and visibility of veins is a crucial step before obtaining intravenous access in the antecubital fossa, which is a common procedure to draw blood or administer intravenous therapies (IV therapies). Even though medical practitioners are highly skilled at intravenous cannulation, they usually struggle to perform the procedure in ...
arxiv +1 more source
Frontiers in Medicine, 2023 BackgroundPostoperative cognitive dysfunction (POCD) is a postoperative complication that often occurs in the elderly. This systematic review and meta-analysis aimed to compare intravenous anesthetics (propofol) with inhalation anesthetics (sevoflurane ...
Leilei Huang, Yong Zhang
doaj +1 more source
Managing Opioid-Tolerant Patients in the Perioperative Surgical Home. [PDF]
, 2016 Management of acute postoperative pain is important to decrease perioperative morbidity and improve patient satisfaction. Opioids are associated with potential adverse events that may lead to significant risk.
Baratta, Jaime L. +3 more
core +3 more sources
Stabilizing membrane domains antagonizes n-alcohol anesthesia [PDF]
Biophysical Journal, Volume 111, Issue 3, 9 August 2016, Pages
537-545, 2016 Diverse molecules induce general anesthesia with potency strongly correlated both with their hydrophobicity and their effects on certain ion channels. We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma membrane derived vesicles by lowering the critical temperature ($T_c$) for phase separation.
arxiv +1 more source
Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery [PDF]
, 2018 ● AIM: To evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery.
Librando, Aloisa +4 more
core +2 more sources
Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]
, 2013 A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated ion channels.
arxiv +1 more source