Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin+17 more
wiley +1 more source
Comparison of intratesticular lidocaine, sacrococcygeal epidural lidocaine and intravenous methadone in cats undergoing castration: a prospective, randomized, investigator-blind clinical trial [PDF]
Adami, C+3 more
core +1 more source
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou+10 more
wiley +1 more source
Injection site reactions of biologics and mitigation strategies
Biological products administered via subcutaneous (SC) injections offer an effective and convenient alternative to those administered via traditional intravenous injections and have gained a significant increase among approved drugs in recent years ...
Li Zhi, Dingjiang Liu, Mohammed Shameem
doaj +1 more source
Intravenous injections of the oncolytic virus M1 as a novel therapy for muscle-invasive bladder cancer. [PDF]
Hu C+11 more
europepmc +1 more source
This study develops a multifunctional CRISPR‐dCas9‐based OMV platform termed OMV‐C9I12, which facilitates the coexpression of CXCL9 and IL‐12 within tumor cells. This platform enhances T cell recruitment and activation, synergizes with anti‐PD‐1/PD‐L1 immunotherapy, and amplifies antitumor T cell immunity.
Hongjin Wang+22 more
wiley +1 more source
Thromboelastographic assessment of the impact of mexiletine on coagulation abnormalities induced by air or normal saline intravenous injections in conscious rats. [PDF]
Nates JL+4 more
europepmc +1 more source
THE EFFECTS ON BLOOD-PRESSURE OF INTRAVENOUS INJECTIONS OF EXTRACTS OF THE VARIOUS ANATOMICAL COMPONENTS OF THE HYPOPHYSIS [PDF]
DEAN LEWIS
openalex +1 more source