Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun+9 more
wiley +1 more source
Efficacy of delayed treatment of China-made Peramivir with repeated intravenous injections in a mouse influenza model: from clinical experience to basal experiment. [PDF]
Li Z+10 more
europepmc +1 more source
Microneedles at the Forefront of Next Generation Theranostics
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang+8 more
wiley +1 more source
STUDIES ON GANGRENE FOLLOWING COLD INJURY. IV. THE USE OF FLUORESCEIN AS AN INDICATOR OF LOCAL BLOOD FLOW: DISTRIBUTION OF FLUORESCEIN IN BODY FLUIDS AFTER INTRAVENOUS INJECTION 1 [PDF]
J. M. Crismon, Frederick A. Fuhrman
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High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni+15 more
wiley +1 more source
Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. [PDF]
Zhang J+11 more
europepmc +1 more source
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová+27 more
wiley +1 more source
THE EFFECTS ON BLOOD-PRESSURE OF INTRAVENOUS INJECTIONS OF EXTRACTS OF THE VARIOUS ANATOMICAL COMPONENTS OF THE HYPOPHYSIS [PDF]
DEAN LEWIS
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This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou+9 more
wiley +1 more source