Results 251 to 260 of about 2,127,832 (378)

Widespread tissue delivery of antagomiRs via intramuscular administration. [PDF]

open access: yesMol Ther Methods Clin Dev
Messios C, Koutsoulidou A, Phylactou LA.
europepmc   +1 more source

Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria.

open access: yesAnnals of the Rheumatic Diseases, 1986
A. Hanglow   +5 more
semanticscholar   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui   +17 more
wiley   +1 more source

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

open access: yesAdvanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang   +16 more
wiley   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

open access: yesAdvanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen   +18 more
wiley   +1 more source

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