Results 251 to 260 of about 2,150,754 (399)

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Real-world treatment patterns for patients with non-infectious uveitis in Japan: a descriptive study using a large-scale claims database (J-CAT study). [PDF]

J Ophthalmic Inflamm Infect
Kusuhara S, Sonoda KH, Kaburaki T, Fujita T, Katayama S, Makishima M, Nakamura T, Nio M, Omoto T, Matsuo-Tezuka Y, Yoshizaki T, Sasaki K, Ri K, Sato K, Goto H.   +14 more
europepmc   +1 more source

Intravenous Injections of Human Mesenchymal Stromal Cells Modulated the Redox State in a Rat Model of Radiation Myelopathy. [PDF]

Evid Based Complement Alternat Med, 2015
Zhang J, Li LB, Qiu Z, Ren HB, Wu JY, Wang T, Bao ZH, Yang JF, Zheng K, Li SL, Wei L, You H.   +11 more
europepmc   +1 more source

Effect of Repeated Intravenous Injections of Bilirubin on Erythropoiesis in Anaemic Dogs [PDF]

, 1940
R. R. Bomford
openalex   +1 more source

Strategic Design of Aptamer‐Guided Aggregation‐Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer

Advanced Science, EarlyView.
This study presents MF3Ec‐TBPP nanoparticles for targeted photodynamic therapy of Luminal A breast cancer. These nanoparticles combine an AIE‐based photosensitizer with an aptamer. Tests show they effectively inhibit tumor growth while protecting healthy tissue via aggregation and dipalmitoylphosphatidylcholine, indicating potential for improved ...
Charlie C. H. Ma, Qingqing Liu, Yue Sui, Wutong Du, Kristy W. K. Lam, Jacky W. Y. Lam, Chao Li, Tengteng Chen, Jianwei Sun, Nuomin Li, Ryan T. K. Kwok, Jianping Chen, Feiyi Sun, Ben Zhong Tang   +13 more
wiley   +1 more source

Clinical, Radiological, and Pathological Features of Cerebral and Spinal Syphilitic Gumma: A Cross-Sectional Study. [PDF]

Int J Gen Med
Zhang W, Xu D, Qin K, Song C, Miao R, Ma X, Kou C, Huang Y.   +7 more
europepmc   +1 more source

A PRELIMINARY REPORT ON THE TREATMENT OF ADVANCED PULMONARY TUBERCULOSIS BY INTRAVENOUS INJECTIONS OF IODOFORM [PDF]

, 1903
T. W. Dewar
openalex   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

INTRAVENOUS INJECTIONS OF AMINO-ACIDS (HYDROLYZED CASEIN) IN POSTOPERATIVE PATIENTS

, 1942
Robert Elman, D. O. Weiner, E. B. Radley
openalex   +2 more sources

AAVrh10 gene therapy ameliorates central and peripheral nervous system disease in canine globoid cell leukodystrophy (Krabbe disease) [PDF]

, 2018
et al,, Jiang, Xuntain, Ory, Daniel S
core   +1 more source