Results 211 to 220 of about 266,509 (337)

Influence of scleral thickness on photodynamic therapy outcomes in central serous chorioretinopathy

open access: yesActa Ophthalmologica, Volume 103, Issue 3, Page e165-e175, May 2025.
Abstract Purpose To test the prognostic role of anterior scleral substantia propria (ASSP) thickness in predicting the 3‐month response after half‐dose photodynamic therapy (PDT) in central serous chorioretinopathy (CSCR) and to assess its clinical relevance of ASSP in different CSCR phenotypes.
Paolo Forte   +11 more
wiley   +1 more source

Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy

open access: yesActa Physiologica, Volume 241, Issue 5, May 2025.
Abstract Aim H+ facilitates metabolic blood flow regulation while negatively impacting cardiac contractility. Cardiovascular consequences of conjugate bases accumulating alongside H+ remain unclear. Here, we evaluate the cardiovascular effects of nine prominent carboxylates—particularly lactate, 3‐hydroxybutyrate, and butyrate—linked to metabolic and ...
Casper Homilius   +5 more
wiley   +1 more source

α‐Adrenoreceptor blocker phentolamine inhibits voltage‐gated sodium channels via the local anaesthetic binding site

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 9, Page 1879-1896, May 2025.
Abstract Background and Purpose Phentolamine is a non‐selective α‐adrenoreceptor antagonist used to reverse local anaesthesia, for example, during dental procedures when a vasoconstrictor is co‐applied. Phentolamine‐mediated vasodilation leads to faster clearance of injected drugs.
Idil Toklucu   +8 more
wiley   +1 more source

Efficacy and safety of a bio‐absorbable antibiotic delivery in calcium sulphate granules for the treatment of osteomyelitis in patients with diabetic foot: A randomized, double blinded, controlled clinical study The BIG D‐FOOT study

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2552-2560, May 2025.
Abstract Background Diabetic foot osteomyelitis (DFO) is associated with a considerably high risk of incident major amputations, disability and mortality. To assess the effects of a local antibiotic delivery system on the incidence of post‐surgical infective complications in patients with DFO.
Matteo Monami   +4 more
wiley   +1 more source

Cryoanalgesia for Pain Management After Pectus Excavatum Repair (COPPER) in Adolescents: A Randomized Controlled Trial

open access: yesPediatric Anesthesia, Volume 35, Issue 5, Page 347-358, May 2025.
ABSTRACT Background Patients undergoing Pectus Excavatum repair with the minimally invasive approach frequently report severe postoperative pain. The goal of the study is to determine the superiority of cryoanalgesia compared to standard of care for return to normal quality of life.
M. Bastianello   +30 more
wiley   +1 more source

Safety of Intrathecal Clonidine as an Adjuvant to Spinal Anesthesia in Infants and Children

open access: yesPediatric Anesthesia, Volume 35, Issue 5, Page 374-379, May 2025.
ABSTRACT Introduction Preliminary clinical studies have demonstrated that clonidine is an effective adjuvant to spinal anesthesia in neonates and infants. However, the studies conducted previously have had a limited cohort size of 80–100, potentially limiting an accurate measure of its safety.
Grant Heydinger   +7 more
wiley   +1 more source

Tissue‐matched analysis of MRI evaluating the tumor infiltrating lymphocytes in hepatocellular carcinoma

open access: yesInternational Journal of Cancer, Volume 156, Issue 8, Page 1634-1643, 15 April 2025.
What's new? Increasing evidence suggests that the evaluation of tumor‐infiltrating lymphocytes both at baseline and throughout cancer therapy can be valuable for predicting and monitoring treatment responses. Tumor heterogeneity however complicates the assessment of tumor‐infiltrating lymphocytes.
Mengqi Huang   +10 more
wiley   +1 more source

Oral Microalgae‐Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng   +8 more
wiley   +1 more source

Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
The strategy of ultra‐small Pd loaded covalent organic framework combined with NIR irradiation (TP@Pd+NIR) is developed to reprogram lung redox homeostasis for the synergistic enhancement of acute lung injury immunotherapy via ROS scavenging, M2 directional polarization, NF‐κB pathway inhibition as well as tissue repair acceleration.
Doudou Lei   +22 more
wiley   +1 more source

Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
Rheumatoid arthritis is an incurable inflammatory autoimmune disease. The cleverly biomimetic nanoplatform integrates nanoenzymes and gene therapeutics and is sequentially modified by guanidinium‐based polymers and macrophage membranes, enhancing the gene silencing capability and reactive oxygen species scavenging efficiency through self‐sustaining ...
Huichao Xie   +12 more
wiley   +1 more source

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