Results 171 to 180 of about 51,926 (267)

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Gas station heroin- tianeptine and its impact: a systematic review and exploratory analysis. [PDF]

BMC Public Health
Parnia S, Jain L, Ali M, Sarfraz Z, Nasir MJ, Shah D, Fnu A, Atiq N, Shaikh PR, Ahmed R, Hower M, Karlapati S, Moazzam MT, Bazin B, Ahmed S.   +14 more
europepmc   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Infective Endocarditis in Patients With a History of Intravenous Drug Abuse. [PDF]

Cureus
Bursy M, Dudek A, Szkudlarek W, Linkiewicz J, Lizurej W, Buda A, Kubik M, Bogdanski A, Bogdanska K, Mazur M.   +9 more
europepmc   +1 more source

Low‐Dose Aspirin Induced Gastric Ulcer in a Patient With TIA: A Clinical Caution for Aspirin Therapy Without Gastroprotection

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Balancing the cerebrovascular benefits of low‐dose aspirin (LDA) with its significant gastrointestinal (GI) bleeding risk is a critical challenge in secondary stroke prevention. We describe a cautionary case of a 60‐year‐old male who, 6 months after starting LDA for a transient ischemic attack (TIA), presented with a life‐threatening upper GI ...
Kainat Husain, Muhammad Ibrahim, Fazeela Bibi, Khalil El Abdi, Bilal Aslam, Abdullah Saud, Vohra Maham Hassan, Aminullah Betanai, Muhammad Muneeb, Said Hamid Sadat   +9 more
wiley   +1 more source

Substance Use and Cardiac Implantable Electronic Devices: A Single Institution Analysis of Re-Hospitalization, Follow-Up Rate, and Complications to Predict Patient Outcomes. [PDF]

Cureus
Stoecker A, Kang P, White MD.
europepmc   +1 more source

Anti‐NMDA Receptor Encephalitis Presenting as Acute Psychosis

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Young adults presenting with acute psychiatric symptoms followed by rapid neurological decline, catatonia, and autonomic instability should prompt consideration of anti–NMDA receptor encephalitis, even without detectable tumors; early recognition and immunotherapy are critical for favorable neurological recovery.
Tatiana Mengistu, Anuj Subedi, Uchenna Unamba, Sajjad Ahmed Khan, Esereoghene Mowoe, Jeremy Lane, Sahar Panah, Huma Kausar   +7 more
wiley   +1 more source

Limited effects of zolmitriptan maintenance on the pharmacodynamic profile of intravenous cocaine in humans. [PDF]

Behav Pharmacol
Stoops WW, Lile JA, Alcorn JL, Hatton KW, Hays LR, Anderson DM, Neisewander JL.   +6 more
europepmc   +1 more source

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng   +6 more
wiley   +1 more source

Clinical Outcomes and Challenges in the Management of Spondylodiscitis in Patients With Intravenous Drug Abuse: A Multicenter Retrospective Study. [PDF]

Global Spine J
Albrecht C, Delank M, Wostrack M, Jelgersma C, Tkatschenko D, Onken J, Neuhoff J, Vajkoczy P, Meyer B, Joerger AK.   +9 more
europepmc   +1 more source