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Annals of Neurology
The benefits of intravenous thrombolysis are time‐dependent, with maximum efficacy when administered within the first “golden” hour after onset. Nevertheless, the impact of golden hour thrombolysis has not been well quantified.
F. Al‐Ajlan +13 more
semanticscholar +1 more source
The benefits of intravenous thrombolysis are time‐dependent, with maximum efficacy when administered within the first “golden” hour after onset. Nevertheless, the impact of golden hour thrombolysis has not been well quantified.
F. Al‐Ajlan +13 more
semanticscholar +1 more source
Intravenous thrombolysis for acute stroke
Neurology, 1997Until recently there was no specific therapy for stroke, but the recent publication of the National Institute of Neurological Disorders and Stroke(NINDS) t-PA for Acute Stroke Trial presents the first effective, specific therapy for stroke.1 In considering whether to apply thrombolysis to any given patient, the physician must consider the factors ...
P D, Lyden +5 more
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Intravenous Thrombolysis in Acute Myocardial Infarction
Chest, 2001(CHEST 2001; 119:253S‐277S) F ibrinolytic therapy for acute myocardial infarction (MI) has been one of the most potent treatments ever developed for a condition that kills more patients worldwide than any other. This review will focus on approved agents and the randomized trials that have led to their widespread use.
Ohman E. +5 more
openaire +3 more sources
Cerebral Perfusion Imaging for Intravenous Thrombolysis Treatment
Topics in Magnetic Resonance Imaging, 2021Abstract Intravenous thrombolysis is the cornerstone of acute ischemic stroke treatment. However, the benefits of recanalization and reperfusion must be balanced against the risk of intracranial hemorrhage. Time from symptom onset was previously the most important selection tool for identifying patients who would benefit from ...
Diana E, Slawski Md +1 more
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Intravenous Thrombolysis for Acute Ischemic Stroke
Continuum, 2023This article reviews the history of IV thrombolysis, its current indications and implementation, the duality of the "time is brain" versus "tissue clock" approaches, the impact of endovascular thrombectomy on IV thrombolysis, the emergence of tenecteplase, and future research directions.The growing use of factor Xa inhibitors has increasingly caused ...
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2010
This chapter will review the basic mechanisms of clot formation (thrombosis) and dissolution (thrombolysis or fibrinolysis), the mechanisms of the major drug classes used in the treatment, and the results from major clinical trials. This chapter will also present evidence-based recommendations and protocols for applying thrombolytic therapy to ...
Raul Nogueira, Lee H. Schwamm
openaire +1 more source
This chapter will review the basic mechanisms of clot formation (thrombosis) and dissolution (thrombolysis or fibrinolysis), the mechanisms of the major drug classes used in the treatment, and the results from major clinical trials. This chapter will also present evidence-based recommendations and protocols for applying thrombolytic therapy to ...
Raul Nogueira, Lee H. Schwamm
openaire +1 more source
International Journal of Stroke, 2019
Background Intravenous thrombolysis with alteplase within a time window up to 4.5 h is the only approved pharmacological treatment for acute ischemic stroke.
P. Ringleb +16 more
semanticscholar +1 more source
Background Intravenous thrombolysis with alteplase within a time window up to 4.5 h is the only approved pharmacological treatment for acute ischemic stroke.
P. Ringleb +16 more
semanticscholar +1 more source
Intravenous thrombolysis for large vessel or distal occlusions presenting with mild stroke severity
European Journal of Neurology, 2020We investigated the effectiveness of intravenous thrombolysis (IVT) in acute ischaemic stroke (AIS) patients with large vessel or distal occlusions and mild neurological deficits, defined as National Institutes of Health Stroke Scale scores < 6 points.
G. Tsivgoulis +37 more
semanticscholar +1 more source
Intracranial tumour haemorrhage following intravenous thrombolysis
Journal of Clinical Neuroscience, 2016Intravenous administration of thrombolytic agents is considered to be contraindicated in patients with intracranial neoplasms. However, only a single case of thrombolysis-related intracranial tumour haemorrhage has been reported to our knowledge and several studies have suggested that systemic thrombolysis can be safely carried out in these patients ...
Christian, Diehl +4 more
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Coronary Thrombolysis with Intravenous Streptokinase
Cardiology Clinics, 1987Coronary thrombolysis can be achieved with several lytic agents administered via the intravenous or intracoronary routes. Streptokinase, when administered intravenously, produces coronary thrombolysis in from 34 to 75 per cent of patients. Intravenous administration has the advantage of rapid administration without the risks or delays inherent in the ...
openaire +2 more sources