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Intravenous thrombolysis prior to mechanical thrombectomy in large vessel occlusions
Annals of Neurology, 2019The substantial clinical improvement in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT), combined with the poor response of proximal intracranial occlusions to intravenous thrombolysis (IVT), led to questions regarding the ...
A. Katsanos +14 more
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Intravenous thrombolysis for stroke
BMJ, 2010Elderly patients should not be excluded solely on the basis of age Intravenous thrombolytic treatment for acute ischaemic stroke is controversial in patients over 80 years, mainly because they have been excluded from or under-represented in the large scale randomised controlled trials of such treatment.1 2 3 In the linked study (doi:10.1136/bmj.c6046),
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European Journal of Neurology, 2019
Patients with stroke mimics (SM), i.e. conditions with stroke‐like symptoms, may risk harm if treated with intravenous thrombolysis (IVT). Current guidelines state low risk of intracerebral hemorrhage based on studies comprising a total of
B. Keselman +11 more
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Patients with stroke mimics (SM), i.e. conditions with stroke‐like symptoms, may risk harm if treated with intravenous thrombolysis (IVT). Current guidelines state low risk of intracerebral hemorrhage based on studies comprising a total of
B. Keselman +11 more
semanticscholar +1 more source
Recanalization after intravenous thrombolysis
Neurology, 2007To evaluate the time course of major vessel recanalization under IV thrombolysis in relation to functional outcome in acute ischemic stroke.A total of 99 patients with an acute anterior circulation vessel occlusion who underwent IV thrombolysis were included. All patients had a standardized admission and follow-up procedure.
M T, Wunderlich +7 more
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Off‐label intravenous thrombolysis in acute stroke
European Journal of Neurology, 2011Background and purpose: Therapy for stroke with intravenous tissue plasminogen activator (IV‐tPA) is hampered by tight licensing restrictions; some of them have been discussed in recent literature. We assessed the safety and effectiveness of off‐label IV‐tPA in the clinical settings.Methods: Retrospective analysis of all the patients treated with IV ...
M, Guillan +9 more
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Intravenous Thrombolysis and Coronary Revascularization Rates
JAMA: The Journal of the American Medical Association, 1991To the Editor.— The impact of intravenous thrombolysis on the rates of short-term interventional procedures (cardiac catheterization, angioplasty, and bypass surgery) was addressed recently by Naylor and Jaglal 1 and, in an accompanying editorial, by Schlant.
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Intravenous Thrombolysis for Acute Ischemic Stroke
Journal of Vascular and Interventional Radiology, 2004Intravenous recombinant tissue-type plasminogen activator (rtPA, alteplase) is the only drug approved for the treatment of acute ischemic stroke. It should be administered within 3 hours of stroke. There is additional evidence, however, that administration at later times, by means of other methods, is effective.
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European Review for Medical and Pharmacological Sciences, 2022
Yuansheng Lei +4 more
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Yuansheng Lei +4 more
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Intravenous Thrombolysis and Anti-thrombotics
2016Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) has revolutionized acute ischemic stroke care in the last two decades. The NINDS stroke study was pivotal in this transformation and conclusively demonstrated meaningful clinical improvement when IV rtPA is administered in the first 3 h of symptom onset.
Mahesh P. Kate +2 more
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Journal of the American Medical Association (JAMA), 1995
W. Hacke +9 more
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W. Hacke +9 more
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