Results 181 to 190 of about 132,395 (346)
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT A 42‐year‐old male presented with 1 week of left eye redness, pain, and severe vision loss. Examination revealed anterior chamber fibrin, vitritis, and vitreous opacities. B‐scan ultrasonography showed mobile hyperechoic vitreous material with an attached retina.
Dhruv Sethi +6 more
wiley +1 more source
Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Advances in the Development of Lipid Nanoparticles for mRNA Delivery
Small Structures, Volume 7, Issue 2, February 2026.This review provides an integrated overview of mRNA–lipid nanoparticle (LNP) design, including lipid composition, scalable manufacturing, and structure–activity relationships. We highlight strategies for targeted delivery, physicochemical tuning, and high‐throughput screening such as DNA barcoding.
Xing Wang +6 more
wiley +1 more source
Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep
Brain and BehaviorPurpose Neuronal ceroid lipofuscinoses (NCL; Batten disease) are a group of rare inherited neurodegenerative disorders caused by mutations in one of 13 ceroid lipofuscinosis neuronal (CLN) genes.
Samantha J. Murray +11 more
doaj +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong +9 more
wiley +1 more source
Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD.
New England Journal of Medicine, 2017 Ajay E. Kuriyan +9 more
semanticscholar +1 more source