Results 171 to 180 of about 99,964 (316)

Surgical Approaches to Retinal Gene Therapy: 2025 Update

Bioengineering
Gene therapy offers a promising new frontier in the treatment of inherited and acquired retinal disease. This review describes the current surgical delivery approaches for gene therapy to the retina—subretinal, suprachoroidal, and intravitreal—and ...
Milin J. Patel, Sohum Sheth, Jessica Mar, Ninel Z. Gregori, Jesse D. Sengillo   +4 more
doaj   +1 more source

Evaluation for endotoxin in intraocular materials used during phacoemulsification surgery using a recombinant factor C assay

Veterinary Ophthalmology, Volume 28, Issue 2, Page 481-485, March 2025.
Abstract Objective Cataract surgery remains the sole method to resolve blindness secondary to cataract formation. One complication includes fibrin web formation post‐operatively. This study aimed to investigate the presence of endotoxin within materials used during cataract surgery as a possible cause of fibrin web phenomenon. Methods Preservative‐free
Taylor A. Opgenorth, Eryn L. Opgenorth, J. Seth Eaton, Ellison Bentley   +3 more
wiley   +1 more source

Immediate sequential bilateral intravitreal injections: an Indian perspective [PDF]

, 2017
Koushik Tripathy Department of Vitreoretina and Uvea, ICARE Eye Hospital and Postgraduate Institute, Sector-26, Noida, Uttar Pradesh, IndiaRecently, Ruão et al1 have shown in a study spanning 6 years that only 1 of 6560 (0.015%) eyes undergoing ...
Tripathy K
core  

Techniques for subretinal injections in animals

Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley   +1 more source

Pseudophakic macular edema in a steroid responder treated successfully with intravitreal methotrexate: A case report

Indian Journal of Ophthalmology. Case Reports
Pseudophakic macular edema (PME) is typically treated with nonsteroidal anti-inflammatory drugs (NSAIDs) initially, followed by steroids. Treatment with steroids becomes challenging in steroid responders. We report a case of PME treated with intravitreal
Simran, Suresh Ramchandani, Shubhangi Mahesh, Fatema Lokhandwala   +3 more
doaj   +1 more source

Efficacy of 0.2% povidone‐iodine and 0.1% polyhexamethylene biguanide as preoperative antiseptics in equine ophthalmic procedures

Veterinary Ophthalmology, Volume 28, Issue 2, Page 438-447, March 2025.
Abstract Objective This retrospective study evaluates the efficacy of povidone‐iodine (PI) and polyhexamethylene biguanide (PHMB) as preoperative antiseptics in equine ophthalmic procedures. Animals Studied Horses that underwent routine ophthalmic surgery and procedures.
Anna Farkas, Katharina Thieme, Tanawan Soimala, Charlotte K. Jensen, J. Corinna Eule   +4 more
wiley   +1 more source

A protocol for the retina surgeon’s safe initial intravitreal injections [PDF]

, 2010
Ronald EP Frenkel1,2, Shamim A Haji1,2, Melvin La1, Max PC Frenkel1, Angela Reyes11Eye Research Foundation, Stuart, FL, USA; 2East Florida Eye Institute, Stuart, FL, USAPurpose: To determine the safety of a surgeon’s initial consecutive ...
et al, Melvin La, Ronald EP Frenkel, Shamim A Haji   +3 more
core  

Moutan Cortex Extract Mediates Diabetic Retinopathy by Blocking the ROS‑Triggered HIF‐1α/VEGF Axis in Retinal Pigment Epithelial Cells

eFood, Volume 7, Issue 4, August 2026.
Schematic diagram of the mechanism by which Moutan Cortex extract (MCE) ameliorates DR. MCE alleviates retinal structural damage and reduces neovascular lesions by downregulating the ROS/HIF‐1α/VEGF signaling axis. ABSTRACT Moutan Cortex is a functional food ingredient with multiple health benefits, but its effects on diabetic retinopathy (DR) remain ...
Mei‐rong Li, Xian‐yi Zhang, Wan‐ying Zhang, Nan Chen, Wei‐wei Lv, Tian‐yu Liu, Xu Guo, Ying‐ying Chen, Meng‐qi Zhang, Shu‐tao Sun, Mu‐xuan Wang, Qi‐dong Ren, Chao Liu, Jin‐yue Sun   +13 more
wiley   +1 more source

Retinal progenitor cells (jCell) for retinitis pigmentosa

Frontiers in Cellular Neuroscience
ObjectiveTo assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).DesignA prospective, multicenter, open-label, single-arm ...
Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen   +11 more
doaj   +1 more source

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source