Results 151 to 160 of about 78,474 (272)
Aging Cell, Volume 25, Issue 5, May 2026.A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins +8 more
wiley +1 more source
Acta Ophthalmologica, Volume 104, Issue 3, Page 296-304, May 2026.Abstract Purpose To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age‐related macular degeneration (nAMD). Methods This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti‐VEGF therapies at Sahlgrenska University Hospital between February 2024 and ...
Imadeddin Abu Ishkheidem +5 more
wiley +1 more source
Neovascular age‐related macular degeneration without drusen
Acta Ophthalmologica, Volume 104, Issue 3, Page e300-e311, May 2026.Abstract Purpose To describe the clinical characteristics and 1‐year follow‐up of patients with neovascular AMD (nAMD) without drusen in either eye. Methods This is a multicentre retrospective cohort study in three tertiary referral centres in The Netherlands. We included patients of 55 years or older with nAMD in one or both eyes, without the presence
Marc J. Sirks +9 more
wiley +1 more source
Acta Ophthalmologica, Volume 104, Issue 3, Page 259-266, May 2026.Abstract Purpose Pregnancy induces significant changes in the body, including increased peripheral and choroidal blood perfusion and an increased systemic corticosteroid level. Here, we systematically reviewed the evidence on pregnancy as a risk factor for developing central serous chorioretinopathy (CSC) and conducted a meta‐analysis to obtain a ...
Nathalie Skovgaard Eriksen +15 more
wiley +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
Genes to Cells, Volume 31, Issue 3, May 2026.The effects of intraocular administration of neutralizing antibodies against VEGFA, ANG‐2, or bispecific to these two factors on pathological findings were examined in the oxygen‐induced retinopathy (OIR) mouse model. The antibody to VEGFA or ANG‐2 attenuated oxygen‐induced neovascularization and inflammation, and the bispecific antibody more ...
Hirokazu Oohashi +8 more
wiley +1 more source
Veterinary Ophthalmology, Volume 29, Issue 3, May 2026.ABSTRACT Objective To describe the clinical outcome of intravitreal cidofovir injection for palliative management of refractory end‐stage glaucoma and vision loss in silicone oil‐filled eyes following retinal reattachment surgery in dogs. Procedures Medical records of dogs that underwent a single intravitreal cidofovir injection for pharmacologic ...
Sunhyo Kim, Jaeho Shim
wiley +1 more source
Comparison of the clinical effect of intravitreal ranibizumab and intravitreal dexamethasone implants in the treatment of retinal vein occlusion complicated with macular oedema: a meta-analysis. [PDF]
BMC OphthalmolLi Y, Hu L, Zu J.
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala +3 more
wiley +1 more source