Results 131 to 140 of about 78,474 (272)

Prognostic Factors in Patients With Submacular Haemorrhage Complicating Age‐Related Macular Degeneration: A Post Hoc Analysis of the STAR Study

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To investigate prognostic factors of recent submacular haemorrhage (SMH) complicating neovascular age‐related macular degeneration (nAMD) treated with surgery or pneumatic displacement combined with intravitreal injection of anti‐vascular endothelial growth factor.
Pierre‐Henry Gabrielle, Petra Eid, Ludwig Serge Aho, Laurent Kodjikian, Eric Souied, Joel Uzzan, Jean Baptiste Conart, Marie‐Noëlle Delyfer, Catherine Creuzot‐Garcher   +8 more
wiley   +1 more source

Rapid and Accurate Pressure Sensing Device for Direct Measurement of Intraocular Pressure. [PDF]

, 2020
PurposeIntraocular pressure (IOP) is the primary modifiable risk factor for glaucoma. Current devices measure IOP via the dynamic response of the healthy cornea and do not provide the accurate IOP measurements for patients with altered corneal ...
Camp, Andrew, Friend, James, Gopesh, Tilvawala, Unanian, Michael, Weinreb, Robert N   +4 more
core  

Stage‐Associated Microglial Subpopulations and Dynamics in Vascular Pathogenesis of Oxygen‐Induced Retinopathy

Cell Proliferation, EarlyView.
In the oxygen‐induced retinopathy (OIR) mouse model, two distinct microglial subpopulations play opposing roles: highly glycolytic microglia (HGM) promote neovascular formation via Pkm2, while Mrc1/CD206‐positive phagocytosis‐associated microglia (PAM) facilitate its regression.
Yuan Ma, Ziye Chen, Baoyi Liu, Wen Ding, Runping Duan, Kangjie Kong, Zhuojun Xu, Jizhu Li, Jiali Ru, Dianlei Guo, Xiaoyue Wei, Yaping Liu, Zhuangling Lin, Yang Meng, Yuan Liu, Lan Jiang, Zitong Chen, Rebiya Tuxun, Chinling Tsai, Chunqiao Liu, Tao Li   +20 more
wiley   +1 more source

Visual Responses in Mice Lacking Critical Components of All Known Retinal Phototransduction Cascades [PDF]

, 2010
The mammalian visual system relies upon light detection by outer-retinal rod/cone photoreceptors and melanopsin-expressing retinal ganglion cells. Gnat1(-/-); Cnga3(-/-); Opn4(-/-) mice lack critical elements of each of these photoreceptive mechanisms ...
Allen, AE, Brown, TM, Cameron, MA, Lucas, RJ, Vugler, AA   +4 more
core  

Safety and effectiveness of brolucizumab in patients with neovascular age-related macular degeneration: A phase IV study from India

Indian Journal of Ophthalmology
Purpose: The purpose of this study is to evaluate the safety and effectiveness of brolucizumab intravitreal injections (IVI) in Indian patients with neovascular age-related macular degeneration (nAMD).
Asim K Ghosh, Debdulal Chakraborty, Aditya Sudhalkar, Rohan Chawla, Simar R Singh, Atul K Sahu, Ramesh Venkatesh, Vishal Raval, Sonali Shah, Padma Preetha, Maulik Bhavsar, Sandip Patil, Isha Khadke, Anup Thorat   +13 more
doaj   +1 more source

Health, hope and worry: A qualitative study of people with diabetes' experiences with anti‐VEGF treatment

Diabetic Medicine, EarlyView.
Abstract Aims Diabetic macular edema (DME) is a leading cause of vision loss among individuals with diabetes. While anti‐VEGF therapy is a widely used and effective treatment, limited research has explored participants' lived experiences throughout the treatment process.
J. K. Leksell, E. Granstam, T. Granström, E. Nerpin   +3 more
wiley   +1 more source

Surgical Approaches to Retinal Gene Therapy: 2025 Update

Bioengineering
Gene therapy offers a promising new frontier in the treatment of inherited and acquired retinal disease. This review describes the current surgical delivery approaches for gene therapy to the retina—subretinal, suprachoroidal, and intravitreal—and ...
Milin J. Patel, Sohum Sheth, Jessica Mar, Ninel Z. Gregori, Jesse D. Sengillo   +4 more
doaj   +1 more source

Association of SGLT2 Inhibitor With Stroke in Type 2 Diabetes With Diabetic Retinopathy: A Multicenter Electronic Health Record Data Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic retinopathy (DR) is linked to elevated risks of cerebrovascular diseases. Whether sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) reduce stroke risk in patients with type 2 diabetes (T2D) and DR remains uncertain. Materials and Methods We conducted a retrospective cohort study using the TriNetX Research Network.
Kuo‐En Chen, Po‐Chun Wang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling

Journal of Diabetes Investigation, EarlyView.
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Jiexin Yu, Xingyu Li, Yanli Liu
wiley   +1 more source

Retinal progenitor cells (jCell) for retinitis pigmentosa

Frontiers in Cellular Neuroscience
ObjectiveTo assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).DesignA prospective, multicenter, open-label, single-arm ...
Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen   +11 more
doaj   +1 more source