Results 61 to 70 of about 235,541 (221)

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Functional and morphological parameters evaluated at each time-point from intravitreal dexamethasone implant.

, 2018
Functional and morphological parameters evaluated at each time-point from intravitreal dexamethasone implant.
Rodolfo Mastropasqua (840601), Paolo Carpineto (840606), Alessandra Mastrocola (840605), Marta Di Nicola (325339), Enrico Borrelli (750198), Luca Di Antonio (840603), Chiara De Nicola (840604), Lisa Toto (840602)   +7 more
core   +1 more source

Comparison of Intravitreal Bevacizumab versus Triamcinolone for the Treatment of Diffuse Diabetic Macular Edema [PDF]

, 2010
Background: Our purpose was to compare the effect of triamcinolone and bevacizumab (Avastin) on the retinal thickness and functional outcome in patients with diabetic macular edema. Methods and Materials: A collective of 32 patients, who had been treated
Haritoglou, Christos, Ulbig, Michael W., Kook, Daniel, Wolf, Armin, Neubauer, Aljoscha Steffen, Kreutzer, Thomas C., Al Saeidi, Rashid   +6 more
core   +1 more source

A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition

Advanced Science, EarlyView.
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Zhidong Chen, Mingshuang Wang, Huiqin Liu, Feng Qian   +3 more
wiley   +1 more source

Dexamethasone intravitreal implant in the crystalline lens: a case report

Arquivos Brasileiros de Oftalmologia, 2020
This report describes the therapeutic effects and outcomes of an accidental injection of an intralenticular sustained-release dexamethasone implant (Ozurdex®) in three patients with diabetic macular edema. All three patients underwent accidental injections of sustained-release intravitreal dexamethasone implants into the crystalline lens by the same ...
Ertan, Elif, Duman, Reşat, Duman, Rahmi, Doğan, Mustafa   +3 more
openaire   +3 more sources

Scleral melt following Retisert intravitreal fluocinolone implant

, 2014
Ilias Georgalas,1 Chrysanthi Koutsandrea,1 Dimitrios Papaconstantinou,1 Dimitrios Mpouritis,1 Petros Petrou1,2 1Ophthalmology Department, University of Athens, Athens, Greece; 2Moorfields Eye Hospital, London, UKAbstract: Intravitreal fluocinolone ...
Papaconstantinou D, Koutsandrea C, Petrou P, Mpouritis D, Georgalas I   +4 more
core   +1 more source

Effect of intravitreal dexamethasone implant on the contralateral eye in recalcitrant radiation maculopathy

Oman Journal of Ophthalmology, 2019
Radiation maculopathy, a subset of significant radiation retinopathy, is one of the most common causes of visual loss following localized, regional, or whole-brain radiotherapy.
Srishti Kamalmani Gulati, Gopal S Pillai, Natasha Radhakrishnan   +2 more
doaj   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Fluocinolone Acetonide 0.19 mg Implant in Patients with Cystoid Macular Edema Due To Irvine–Gass Syndrome

International Medical Case Reports Journal, 2021
João Heitor Marques,1 Ana Carolina Abreu,1 Nisa Silva,1 Angelina Meireles,1,2 Bernardete Pessoa,1,2 João Melo Beirão1,2 1Serviço de Oftalmologia, Centro Hospitalar e Universitário do Porto, Porto, Portugal; 2Instituto ...
Marques JH, Abreu AC, Silva N, Meireles A, Pessoa B, Melo Beirão J   +5 more
doaj  

Clinical and functional evaluation of efficiency in the treatment of macular edema associated with thrombosis of the central retinal vein and its branches

Офтальмохирургия, 2019
Purpose. An assessment of the efficacy of a prolonged corticosteroid and anti-VEGF therapy in the treatment of macular edema with thrombosis of the central retinal vein and its branches.Material and methods.
T. G. Kamenskikh, Y. S. Batishcheva, E. V. Gileva, I. O. Kolbenev   +3 more
doaj   +1 more source