Results 161 to 170 of about 50,700 (273)

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

Attenuation of Oxygen‐Induced Neovascularization and Inflammation by Neutralizing VEGFA and/or ANG‐2 With an Antibody

Genes to Cells, Volume 31, Issue 3, May 2026.
The effects of intraocular administration of neutralizing antibodies against VEGFA, ANG‐2, or bispecific to these two factors on pathological findings were examined in the oxygen‐induced retinopathy (OIR) mouse model. The antibody to VEGFA or ANG‐2 attenuated oxygen‐induced neovascularization and inflammation, and the bispecific antibody more ...
Hirokazu Oohashi, Toshiro Iwagawa, Hiroto Abe, Chihiro Kawaji, Yuta Inokuchi, Tetsuhiro Soeda, Kosuke Saita, Makoto Aihara, Sumiko Watanabe   +8 more
wiley   +1 more source

A second occurrence of intravitreal injection-associated endophthalmitis 2 years apart. [PDF]

Am J Ophthalmol Case Rep
Rohowetz LJ, Flynn HW, Townsend JH.
europepmc   +1 more source

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 751-765, May 2026.
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Jiexin Yu, Xingyu Li, Yanli Liu
wiley   +1 more source

AAV2-Retro-Mediated Gene Transfer Selectively Targets Outer Retinal Cells Following Intravitreal Injection. [PDF]

Invest Ophthalmol Vis Sci
Kinane C, Panchal M, Tsoulfas P, Talla V, Park KK.   +4 more
europepmc   +1 more source

Intravitreal Cidofovir Injection for Refractory End‐Stage Glaucoma and Vision Loss in Silicone Oil‐Filled Eyes Following Retinal Reattachment Surgery in Dogs: Four Cases

Veterinary Ophthalmology, Volume 29, Issue 3, May 2026.
ABSTRACT Objective To describe the clinical outcome of intravitreal cidofovir injection for palliative management of refractory end‐stage glaucoma and vision loss in silicone oil‐filled eyes following retinal reattachment surgery in dogs. Procedures Medical records of dogs that underwent a single intravitreal cidofovir injection for pharmacologic ...
Sunhyo Kim, Jaeho Shim
wiley   +1 more source

Electroretinographic Response Following Inadvertent Intravitreal Injection of Lidocaine 2. [PDF]

J Vitreoretin Dis
Ueberroth JA, Oellers PR, Eliott D.
europepmc   +1 more source

Cell‐Type‐Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala, Larissa J. Trevino, Tyler M. Black, Raju V. S. Rajala   +3 more
wiley   +1 more source

Large asymptomatic intraocular silicone oil droplet following intravitreal injection. [PDF]

Eur J Ophthalmol
Ma TA, Chehade LK, Durkin S, Chan WO.
europepmc   +1 more source

How to treat recurrences after Avastin treatment for neovascular AMD: stick to Avastin or switch to Lucentis? [PDF]

, 2008
Haritoglou, Christos, Kampik, Anselm, Kook, Daniel, Strauss, R., Wolf, Armin   +4 more
core   +1 more source