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Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

open access: yesNature Reviews Cardiology, 2020
The number of old people is rising worldwide, and advancing age is a major risk factor for atherosclerotic cardiovascular disease. However, the mechanisms underlying this phenomenon remain unclear.
Daniel J Tyrrell, Daniel R Goldstein
exaly   +2 more sources
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Cubilin, the intrinsic factor-vitamin B12 receptor in development and disease.

Current Medicinal Chemistry, 2020
Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic substances including albumin, vitamin D-binding protein or cadmium ...
R. Kozyraki, O. Cases
semanticscholar   +1 more source

Intrinsic Capacity: Validation of a New WHO Concept for Healthy Ageing in a Longitudinal Chinese Study.

The journals of gerontology. Series A, Biological sciences and medical sciences, 2021
BACKGROUND The World Health Organization has proposed a model of healthy aging built around the concept of functional ability, comprising an individual's intrinsic capacity, the physical and social environment they occupy, and interactions between the ...
J. Beard   +4 more
semanticscholar   +1 more source

Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa–Factor VIIIa Interactions

Thrombosis and Haemostasis, 2019
A nonasaccharide (FG9) derived from natural fucosylated glycosaminoglycan (FG) is identified as a selective intrinsic factor Xase complex (FIXa-FVIIIa-Ca2+-phospholipid, FXase) inhibitor that possesses potential inhibition of venous thrombus in rats and ...
Chuang Xiao   +4 more
semanticscholar   +1 more source

Synthesis of Fucosylated Chondroitin Sulfate Nonasaccharide as a Novel Anticoagulant Targeting Intrinsic Factor Xase Complex.

Angewandte Chemie, 2018
Fucosylated chondroitin sulfate (FuCS) is a structurally distinct glycosaminoglycan, and its oligosaccharides exhibit excellent anticoagulant activity with lower risks of adverse effects and bleeding.
Xiao Zhang   +6 more
semanticscholar   +1 more source

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