Results 41 to 50 of about 16,925,605 (335)

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

open access: yesCell, 1997
Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood.
S. R. Datta   +6 more
semanticscholar   +1 more source

Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor

open access: yesCanadian Journal of Gastroenterology, 1989
An 18-year-old French Canadian student presenting with a severe normocytic anemia, had undetectable serum cobalamin but normal gastric acidity and no evidence of generalized malabsorption. The gastric juice contained a normal quantity of intrinsic factor.
Jeanne Drouin, Nadia Mikhael
doaj   +1 more source

Supraspinatus tendon thickness and subacromial impingement characteristics in younger and older adults

open access: yesBMC Musculoskeletal Disorders, 2022
Background Subacromial impingement (SAI) may be a cause of age-related rotator cuff abnormalities; therefore, the purpose of this study was to compare SAI characteristics between younger and older adults.
Tomonobu Ishigaki   +4 more
doaj   +1 more source

The structure and predictive value of intrinsic capacity in a longitudinal study of ageing

open access: yesBMJ Open, 2019
Objectives To assess the validity of the WHO concept of intrinsic capacity in a longitudinal study of ageing; to identify whether this overall measure disaggregated into biologically plausible and clinically useful subdomains; and to assess whether total
John R Beard   +3 more
doaj   +1 more source

VLBI observations of seven BL Lac objects from RGB sample

open access: yes, 2007
We present EVN observations of seven BL Lac objects selected from the RGB sample. To investigate the intrinsic radiation property of BL Lac objects, we estimated the Doppler factor with the VLA or MERLIN core and the total 408 MHz luminosity for a sample
Albert   +61 more
core   +1 more source

Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF) activity. [PDF]

open access: yesPLoS ONE, 2013
HIV-1 acquisition can be prevented by broadly neutralizing antibodies (BrNAbs) that target the envelope glycoprotein complex (Env). An ideal vaccine should therefore be able to induce BrNAbs that can provide immunity over a prolonged period of time, but ...
Gözde Isik   +5 more
doaj   +1 more source

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

open access: yesFunction, 2021
Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe three
Stuart J Keppie   +11 more
doaj   +1 more source

Consistency of objective Bayes factors as the model dimension grows

open access: yes, 2010
In the class of normal regression models with a finite number of regressors, and for a wide class of prior distributions, a Bayesian model selection procedure based on the Bayes factor is consistent [Casella and Moreno J. Amer. Statist. Assoc. 104 (2009)
Casella, George   +2 more
core   +1 more source

When B12 therapy fails: two case reports of intravenous vitamin B12 resistance in pernicious anemia

open access: yesKhyber Medical University Journal
BACKGROUND: Pernicious anemia is an autoimmune disorder causing vitamin B12 deficiency resulting from impaired absorption caused by intrinsic factor absence. Positive parietal cell and intrinsic factor antibodies confirm the diagnosis.
Zeeshan Shaikh   +5 more
doaj   +1 more source

PENGALAMAN BERORGANISASI DALAM MEMBENTUK SOFT SKILL MAHASISWA

open access: yesJurnal Pendidikan Ilmu Sosial, 2018
The purposes of this study are to determine what factors affect the students of the Faculty of Teacher Training and Education (FKIP) Muhammadiyah University of Surakarta and to find out how important the experience of organizing in forming soft skill ...
Suranto Suranto, Famila Rusdianti
doaj   +1 more source

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