Results 41 to 50 of about 5,352,135 (299)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

Function, 2021
Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe three
Stuart J Keppie, Jessica C Mansfield, Xiaodi Tang, Christopher J Philp, Helen K Graham, Patrik Önnerfjord, Alanna Wall, Celia McLean, C Peter Winlove, Michael J Sherratt, Galina E Pavlovskaya, Tonia L Vincent   +11 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A Shorter Form of the Work Extrinsic and Intrinsic Motivation Scale: Construction and Factorial Validation [PDF]

, 2022
While workplace mental health has attracted attention in many countries, work motivation remains under-researched. Research identified that work motivation is associated with many organisational positive outcomes including workplace mental health.
Nelly Otoo, Elaina Taylor, Taylor, Elaina, Kotera, Yasuhiro, Rushforth, Annabel, Colman, Rory, Otoo, Nelly, Muhammad Aledeh, Yasuhiro Kotera, Annabel Rushforth, Rory Colman, Aledeh, Muhammad   +11 more
core   +1 more source

The effect of titanium dioxide particles of different shapes and sizes on the factor XII protein (intrinsic coagulation pathway)

Medicine Science, 2021
Titanium dioxide (TiO2) nanoparticles are widely used in food, cosmetics, biomedical implants, and pharmaceutical fields. Their effect on blood coagulation in human plasma and blood have been demonstrated.
Evren Kilinc
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Hierarchical confirmatory factor analysis of the flow state scale in exercise [PDF]

, 2000
In this study, we examined the factor structure and internal consistency of the Flow State Scale using responses of exercise participants.This self-report questionnaire consists of nine subscales designed to assess flow in sport and physical activity. It
Terry, PC, Terry, Peter C., Karageorghis, Costas I., Vlachopoulos, SP, Vlachopoulos, Symeon P., Karageorghis, CI   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Default Priors in a Zero-Inflated Poisson Distribution: Intrinsic Versus Integral Priors

Mathematics
Prior elicitation is an important issue in both subjective and objective Bayesian frameworks, where prior distributions impose certain information on parameters before data are observed.
Junhyeok Hong, Kipum Kim, Seong W. Kim
doaj   +1 more source