Results 61 to 70 of about 5,352,135 (299)

Evaluating intrinsic and non-intrinsic cancer risk factors [PDF]

Nature Communications, 2018
AbstractDiscriminating the contribution of unmodifiable random intrinsic DNA replication errors (‘bad luck’) to cancer development from those of other factors is critical for understanding cancer in humans and for directing public resources aimed at reducing the burden of cancer.
Song Wu, Wei Zhu, Patricia Thompson, Yusuf A Hannun   +3 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Tonoplast intrinsic proteins and vacuolar identity [PDF]

, 2010
TIPs (tonoplast intrinsic proteins) have been traditionally used as markers for vacuolar identity in a variety of plant species and tissues. In the present article, we review recent attempts to compile a detailed map of TIP expression in Arabidopsis, in ...
Gattolin, Stefano, Frigerio, Lorenzo, Sorieul, Mathias   +2 more
core   +1 more source

Intrinsic DNA codes govern distinct modes of nucleosome-transcription factor interactions

Nature Communications
The interplay between transcription factors (TFs) and nucleosomes is central to gene regulation, yet most studies adopt a protein-centric perspective that largely overlooks DNA sequence contributions.
Christopher W. Carson, Sheethal Umesh Nagalakshmi, Image Adhikari, Julia M. Freewoman, Joseph R. Pizzi, Prakyat Prakash, Feng Cui   +6 more
doaj   +1 more source

Intrinsic factorization of ideals in Dedekind domains [PDF]

ACM Communications in Computer Algebra, 2019
We present a generalization of a polynomial factorization algorithm that works with ideals in maximal orders of global function fields. The method presented in this paper is intrinsic in the sense that it does not depend on the embedding of the ring of polynomials into the Dedekind domain in question.
Mawunyo Kofi Darkey-Mensah, Przemyslaw Koprowski   +1 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Masked vitamin B12 deficiency in pernicious anaemia: A diagnostic trap due to assay interference—Case report

SAGE Open Medical Case Reports
Megaloblastic anaemia is mainly caused by vitamin B12 or folate deficiency. However, rare cases present with discordant laboratory findings, particularly falsely elevated vitamin B12 levels due to assay interference from anti-intrinsic factor antibodies,
Mohammed Abdulgayoom, Elabbass Abdelmahmuod, Abdulrahman F. Al-Mashdali, Yara R. Abuazab, Aliaa Amer, Ibrahim Ganwo, Shehab Mohamed   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

VCSEL intrinsic response extraction using T-Matrix formalism [PDF]

, 2009
We present a new method to remove the parasitics contribution to the VCSEL chip response, in order to obtain the intrinsic S21 behavior. The on-chip VCSEL is defined as two cascaded two-port subsystems representing the electrical access and the VCSEL ...
Sirbu, A., Iakovlev, Vladimir, Bacou, A., Rissons, A., Iakovlev, V., Bacou, Alexandre, Mollier, Jean-Claude, Kapon, Eli, Kapon, E., Hayat, A., Mollier, J.C., Rissons, Angélique, Sirbu, Alexei, Hayat, Ahmad   +13 more
core   +1 more source