Results 61 to 70 of about 708,095 (300)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Identification and characterization of a pancreatic intrinsic factor in the dog [PDF]

open access: yes, 1989
An intrinsic factor has been identified in the canine pancreas, and output and properties of this protein have been compared with those of gastric intrinsic factor in the dog.
L. McLean   +4 more
core   +1 more source

Self-concept and intrinsic motivation in foreign language learning: The connection between flow and the L2 self

open access: yesFrontiers in Education, 2022
An increasingly globalized economy requires a workforce with multilingual capability. However, the United States education system has de-emphasized foreign language learning, such as in the No Child Left Behind Act (NCLB), hurting the recruitment and ...
Jacob M. Marszalek   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

A UNIFORM CORRELATION BETWEEN SYNCHROTRON LUMINOSITY AND DOPPLER FACTOR IN GAMMA-RAY BURSTS AND BLAZARS: A HINT OF SIMILAR INTRINSIC LUMINOSITIES? [PDF]

open access: yes, 2011
We compile 23 gamma-ray bursts (GRBs) and 21 blazars with estimated Doppler factors, and the Doppler factors of GRBs are estimated from their Lorentz factors by assuming their jet viewing angles theta -> 0 degrees.
Ding-Xiong Wang   +9 more
core   +1 more source

Default Priors in a Zero-Inflated Poisson Distribution: Intrinsic Versus Integral Priors

open access: yesMathematics
Prior elicitation is an important issue in both subjective and objective Bayesian frameworks, where prior distributions impose certain information on parameters before data are observed.
Junhyeok Hong, Kipum Kim, Seong W. Kim
doaj   +1 more source

NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

open access: yeseLife, 2021
NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the role of NusG in this process was unknown.
Zachary F Mandell   +6 more
doaj   +1 more source

Studies on Antibody to Intrinsic Factor * [PDF]

open access: yesJournal of Clinical Investigation, 1967
Sera from a group of 79 patients with pernicious anemia were studied for the presence of antibody to intrinsic factor. Two general types of antibody activity were found, and it was possible to distinguish three groups of pernicious anemia sera on the basis of their content of these types.
Stanley G. Schade   +4 more
openaire   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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