Results 81 to 90 of about 708,095 (300)
SAGE Open Medical Case ReportsMegaloblastic anaemia is mainly caused by vitamin B12 or folate deficiency. However, rare cases present with discordant laboratory findings, particularly falsely elevated vitamin B12 levels due to assay interference from anti-intrinsic factor antibodies,
Mohammed Abdulgayoom +6 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Inhibition of Factor XI Using RBD4059
JACC: Basic to Translational ScienceSummary: Coagulation factor XI (FXI) is an attractive target for novel antithrombotic drugs because of its minor role in hemostasis, which may address the current unmet medical need regarding a powerful anticoagulant with low bleeding risk.
Junshi Liang, MSc +13 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The Work Motivation Inventory: Scale Development and Initial Validation in Chinese Working Samples
Journal of Pacific Rim PsychologyGrounded in Self-Determination Theory (SDT) and Vallerand's hierarchical model of intrinsic and extrinsic motivation, this research developed the Work Motivation Inventory (WMI).
Yiou Guo, Jian Li
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Vitamin B12-intrinsic factor studies with isolated perfused rat liver [PDF]
, 1961 Vitamin B12-intrinsic factor relationships have been studied with the isolated perfused rat liver technique. Approximately 20 times more vitamin B12 is absorbed by the liver in the presence of intrinsic factor than without it.
Milton Toporek
core +1 more source
Factor XII (Hageman Factor) Deficiency: a rare harbinger of life threatening complications
The Pan African Medical Journal, 2019 Hageman factor (factor XII) has a key role in activation of intrinsic coagulation system gauged by activated partial thromboplastin time (aPPT)).
Liaqat Ali Chaudhry +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source