Results 71 to 80 of about 5,352,135 (299)

Inhibition of Factor XI Using RBD4059

JACC: Basic to Translational Science
Summary: Coagulation factor XI (FXI) is an attractive target for novel antithrombotic drugs because of its minor role in hemostasis, which may address the current unmet medical need regarding a powerful anticoagulant with low bleeding risk.
Junshi Liang, MSc, Sofia Nilsson, MSc, Johannes Wikström, PhD, Huiqing Cao, PhD, Shuquan Zheng, PhD, Qian Xu, BSc, Xu Yan, MSc, Sebastian Ueckert, PhD, Qi Sun, MSc, Chun Guo, PhD, Hongyan Zhang, PhD, Zicai Liang, PhD, Shan Gao, PhD, Li-Ming Gan, MD, PhD   +13 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Work Motivation Inventory: Scale Development and Initial Validation in Chinese Working Samples

Journal of Pacific Rim Psychology
Grounded in Self-Determination Theory (SDT) and Vallerand's hierarchical model of intrinsic and extrinsic motivation, this research developed the Work Motivation Inventory (WMI).
Yiou Guo, Jian Li
doaj   +1 more source

Evidence for an intrinsic factor promoting landscape divergence in Madagascan leaf-litter frogs

Frontiers in Genetics, 2015
The endemic Malagasy frog radiations are an ideal model system to study patterns and processes of speciation in amphibians. Large-scale diversity patterns of these frogs, together with other endemic animal radiations, led to the postulation of new and ...
Katharina C. Wollenberg Valero
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration [PDF]

, 2010
Background: Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons ...
Bernadette ZY Wong, Shokouhi, B.N., Lieberman, A.R., Tohyama, K., Wong Bernadette ZY, Campbell, G., Koujiro Tohyama, Anderson Patrick N, Gregor Campbell, Tohyama Koujiro, Campbell Gregor, Samir Siddiqui, Siddiqui, S., Patrick N Anderson, A Robert Lieberman, Bahman N Shokouhi, Wong, B.Z.Y., Shokouhi Bahman N, Anderson, P.N., Lieberman A Robert, Siddiqui Samir   +20 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Evolution of corporate governance towards intrinsic value [PDF]

, 2019
The major research question addressed by this paper is how to evolve corporate governance beyond its traditional shareholder focus towards the broader perspective of a stakeholder focus with intrinsic value.
Grove H, Lockhart J
core   +1 more source

Intrinsic electronic transport and thermoelectric power factor in n-type doped monolayer MoS2

New Journal of Physics, 2018
The electronic transport and thermoelectric properties in n -type doped monolayer MoS _2 are investigated by a parameter-free method based on first-principles calculations, electron–phonon coupling (EPC), and Boltzmann transport equation (BTE ...
Yinchang Zhao, Zhenhong Dai, Chao Zhang, Chao Lian, Shuming Zeng, Geng Li, Sheng Meng, Jun Ni   +7 more
doaj   +1 more source