Results 81 to 90 of about 1,196,266 (277)
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
Biology of Sex Differences, 2023 Background The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the shell region of the NAc (NAcSh) have been implicated in driving the motivation to seek reward through ...
Caroline S. Johnson +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Frontiers in PsychologyIt has become an emerging idea for fitness apps to be gamified to intrinsically and extrinsically motivate user’s usage intention or behavior. For the long-term success of gamified fitness apps, understanding what and how various motivations affect ...
Jialiang Huang, Jiang Chen, Liyun Zhou
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Developing Psychological Contracts of Justice in Improving Employee's Satisfaction at Perum Damri
AMAR (Andalas Management Review), 2019 This study aims to examine the predictors and consequences of a fair psychology contract. There are relationships between the degree of reciprocal trust and fair psychological contracts, reward mechanisms for fair psychology contracts, assessment of ...
Akmal Akmal, Elfitra Azliyanti
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On Learning Intrinsic Rewards for Policy Gradient Methods
CoRR, 2018 In many sequential decision making tasks, it is challenging to design reward functions that help an RL agent efficiently learn behavior that is considered good by the agent designer. A number of different formulations of the reward-design problem, or close variants thereof, have been proposed in the literature.
Zeyu Zheng +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Japanese Work Ethic and Culture
Annals of Business Administrative Science, 2015 Takahashi (2004) advocates the Japanese-style seniority-based system, particularly the idea of “new work in reward for work,” which is termed as the Work–Work Theory.
Nobuo TAKAHASHI
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
SA Journal of Industrial Psychology, 2016 Orientation: Local football contributes significantly to the social- and economic welfare of South Africa through its spectators. Understanding the motives and experiences of football spectators could provide opportunities for capitalising on football as
Frederick W. Stander +1 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source