Results 41 to 50 of about 8,960,108 (241)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A Single-Stage Isolated Battery Charger Using Nonbridged Positive Cuk Converter Configuration

open access: yesIET Electrical Systems in Transportation, 2023
This article presents a nonbridged isolated positive Cuk (NB-IPCuk) converter-based single-stage battery charging system (SSBCS). The architecture of the suggested charger ensures the intrinsic advantage of power quality improvement in discontinuous ...
Tanmay Shukla   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Basic Requirements and Design Method of Mine-used Intrinsic Safety Power Supply

open access: yesGong-kuang zidonghua, 2012
Combining with related requirements of new national standard GB3836.4-2010 and Mining Products Safety Approval and Certification Center, the paper analyzed technical performance of mine-used intrinsic safety power supply, namely electrical isolation ...
ZHU Qian-wei
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Firm Power Supply Project Committee Meeting

open access: yes, 2022
Firm Power Supply Project Committee Meeting, January 19 ...
Utah Associated Municipal Power Systems;
core   +2 more sources

Design of Explosion-proof and Intrinsic Safety DC Stabilized UPS Used in Coal Mine

open access: yesGong-kuang zidonghua, 2012
The paper put forward a design scheme of explosion-proof and intrinsic safety DC stabilized UPS used in coal mine based on the principle and characteristics of intrinsic safety power supply, introduced design of main circuit of the power supply.
ZHAO Si-hai, ZHOU Jie
doaj  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

Design of a new type of protection circuit of mine-used intrinsic safety power supply

open access: yesGong-kuang zidonghua, 2013
The paper put forward a design scheme of a new type of protection circuit of mine-used intrinsic safety power supply with LM339 comparator and MAX4080SASA current detection chip based on the analysis of advantages and disadvantages of traditional ...
ZHOU Xue-feng
doaj  

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi   +9 more
wiley   +1 more source

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