Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Psicología Educativa: Revista de los Psicólogos de la EducaciónDrawing on the Expectancy-Value Theory, the present study aims to analyze high school students’ developmental patterns of self-concept of ability, expectancies, intrinsic values, and utility values in various subject areas during the transition to post ...
Milagros Sáinz, Katja Upadyaya
doaj +1 more source
Determining the Conceptual Geometry of Types of Value [PDF]
اخلاق وحیانی, 2012 The issue of virtue and evil of actions has been one of the most important and sect-creating issues in the history of scholastic and ethical thoughts. The numerous topics such as semantic description of virtue & evil of actions, ontological description ...
Ahmad Hossien Sharifi
doaj
[Growth trajectories of intrinsic value beliefs in mathematics and French: Relations with career orientations]. [PDF]
Z Erziehwiss, 2022 Costache O +5 more
europepmc +1 more source
CALCULATING THE EFFECT OF EMPLOYEE STOCK OPTIONS ON DILUTED EPS [PDF]
This paper focuses on how to calculate diluted earnings per share (DEPS) when a firm has outstanding employee stock options (ESOs). Three possible methods are described and compared.
van Zyl, Warrick Boyd
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Gender Differences in Digital Learning During COVID-19: Competence Beliefs, Intrinsic Value, Learning Engagement, and Perceived Teacher Support. [PDF]
Front Psychol, 2021 Korlat S +6 more
europepmc +1 more source
Spiritual Values and Evaluations [PDF]
, 2012 This book explores three easily recognized personality types of great spiritual significance--worldliness, ideology, and saintliness. These spiritual types are defined by the dominant values they manifest--extrinsic, systemic, or intrinsic. The thoughts,
Edwards, Rem Blanchard
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source