Results 71 to 80 of about 6,897,632 (240)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

DEĞER, NORM VE ÇEVRE ETİĞİ

Felsefe Dünyası, 2011
J. Baird Callicott, çevre etiğinin özerk bir disiplin olabilmesi için, insandışı varlıklara özsel değer yüklenilmesinin zorunlu olduğuna inanmaktadır. Yazınınilk bölümünde Callicott’un insan dışı varlıkların özsel değeri hakkındaileri sürdüğü görüşler ...
Mahmut Özer
doaj  

Humans as “Part and Parcel of Nature”: Thoreau’s Contribution to Environmental Ethics

Ethics in Progress, 2014
Henry David Thoreau (1817-1862) develops an understanding of human beings as “part and parcel of nature” that includes the idea that we are physically, spiritually, and attitudinally (more or less) connected to the world around us. The image he offers is
Jason P. Matzke
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Preliminary Considerations on the Main Types of Speleosites in the Apuseni Mountains (Romania) [PDF]

Romanian Review of Regional Studies, 2015
Speleosite assessment is a complex process due to the specificity of caves that contain particular intrinsic values. Eight main categories of speleosites are outlined based on the main intrinsic value of the analyzed sites.
GABRIELA COCEAN
doaj  

The Relations of Science Task Values, Self-Concept of Ability, and STEM Aspirations Among Finnish Students From First to Second Grade

Frontiers in Psychology, 2019
According to modern expectancy-value theory, students’ motivation in school subjects begins to vary at the very beginning of their school careers, showing a task-specific pattern of motivation. However, there is no clear evidence in the literature on how
Janica Vinni-Laakso, Jiesi Guo, Kalle Juuti, Anni Loukomies, Anni Loukomies, Jari Lavonen, Jari Lavonen, Katariina Salmela-Aro, Katariina Salmela-Aro   +8 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source