Results 71 to 80 of about 2,198,841 (282)

Intrinsic fantasy: motivation and affect in educational games made by children [PDF]

open access: yes, 2005
The concept of intrinsic fantasy has been considered central to the aim of usefully applying the positive affect of computer games to learning. Games with intrinsic fantasy are defined as having “an integral and continuing relationship with the ...
Ainsworth, Shaaron   +2 more
core  

On an intrinsic approach of the guiding-center anholonomy and gyro-gauge-arbitrariness

open access: yes, 2013
In guiding center theory, the standard gyro-angle coordinate is associated with gyro-gauge dependence, the global existence problem for unit vectors perpendicular to the magnetic field, and the notion of anholonomy, which is the failure of the gyro-angle
De Guillebon, Loïc, Vittot, Michel
core   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The problem of respect in environmental philosophy

open access: yesStudia Ecologiae et Bioethicae, 2016
The term respect is frequently used in ordinary communication however it also has a significant role in philosophical discussions focused on environmental ethics. This essay deals with the ambiguity of the term respect. The author analyzes respect from a
Barbora Baďurová
doaj   +1 more source

Measuring intrinsic value – how to stop worrying and love economics [PDF]

open access: yes
This paper seeks to transcend entrenched misunderstandings between economists and arts policymakers, leaders and funders. These misunderstandings, which have long dogged discussion on arts funding in the UK, are most evident in the long-running debate ...
Bakhshi, Hasan   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Hedonist Değer Anlayışının Eleştirisi

open access: yesSakarya Üniversitesi İlahiyat Fakültesi Dergisi, 2019
Değer felsefesindeki önemli ayrımlardan birisi özsel değer ve araçsal değer ayrımıdır. Bu ayrıma göre bazı şeyler dışsal ilişkilerinden bağımsız şekilde, kendi doğası itibariyle, özsel şekilde değerli iken bazı şeyler, böyle olmayıp ancak özsel şekilde ...
Ahmet YILDIZ
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Interest Students X Class Of Audio Video Skills Competency SMK N 3 Yogyakarta In Participating Line Follower Robotic Extracurricular [PDF]

open access: yes, 2012
The purpose of final project this thesis is: (1) determine the effect of intrinsic factors to the interest students X class of audio video skills competency SMK N 3 Yogyakarta in participating line follower robotic extracurricular, (2) determine the ...
Andy, Aula
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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