Results 91 to 100 of about 2,198,841 (282)

Rewarding cognitive effort increases the intrinsic value of mental labor. [PDF]

open access: yesProc Natl Acad Sci U S A, 2022
Clay G   +4 more
europepmc   +1 more source

Age-specific growth, reproductive values, and intrinsic r [PDF]

open access: yes
The age-specific growth function of an observed population and the reproductive value function based on the population´s current vital rates determine the intrinsic rate of growth implied by those vital rates through the simple relationship given in ...
Robert Schoen
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The roles of teachers’ beliefs and instructional practices in students’ mathematical mindset

open access: yesFrontiers in Education
IntroductionMathematics education development is an urgent topic, with an emphasis on increasing students’ motivation to learn mathematics.MethodsThis study aimed to investigate the impacts of teachers’ mathematical mindset, task values, and ...
Araya Piyakun, Songsak Phusee-Orn
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

[Growth trajectories of intrinsic value beliefs in mathematics and French: Relations with career orientations]. [PDF]

open access: yesZ Erziehwiss, 2022
Costache O   +5 more
europepmc   +1 more source

Spiritual Values and Evaluations [PDF]

open access: yes, 2012
This book explores three easily recognized personality types of great spiritual significance--worldliness, ideology, and saintliness. These spiritual types are defined by the dominant values they manifest--extrinsic, systemic, or intrinsic. The thoughts,
Edwards, Rem Blanchard
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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