Results 101 to 110 of about 2,176,076 (280)
AscaryaThe question addressed in this article is a possible new epistemological framework to find solutions to the current crisis. The analysis began with the idea of creation as a holistic concept.
Rüdiger Lohlker
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
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Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Felsefe Dünyası, 2011 J. Baird Callicott, çevre etiğinin özerk bir disiplin olabilmesi için, insandışı varlıklara özsel değer yüklenilmesinin zorunlu olduğuna inanmaktadır. Yazınınilk bölümünde Callicott’un insan dışı varlıkların özsel değeri hakkındaileri sürdüğü görüşler ...
Mahmut Özer
doaj
Preliminary Considerations on the Main Types of Speleosites in the Apuseni Mountains (Romania) [PDF]
Romanian Review of Regional Studies, 2015 Speleosite assessment is a complex process due to the specificity of caves that contain particular intrinsic values. Eight main categories of speleosites are outlined based on the main intrinsic value of the analyzed sites.
GABRIELA COCEAN
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
, 2022 Next I will assess the current health of the asset on the basis of its own fundamentals. You can go to the “tldr” summary at the end if you want to skip straight to my conclusions on price predictions. (Disclaimer: This is not financial advice, make sure to always do your own research).
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