Results 121 to 130 of about 29,703 (304)

Importin-α-mediated nucleolar localization of potato mop-top virus TRIPLE GENE BLOCK1 (TGB1) protein facilitates virus systemic movement, whereas TGB1 self-interaction is required for cell-to-cell movement in Nicotiana benthamiana

, 2015
This work was supported by the Swedish Research Council Formas (to E.I.S.), the Carl Tryggers Foundation (to E.I.S. and N.I.L.), the Swedish Institute (to N.I.L.), and the Rural and Environmental Science and Analytical Services Division strategic ...
Savenkov, Eugene I., Cowan, Graham H., Lukhovitskaya, Nina I., Tilsner, Jens, Torrance, Lesley, Vetukuri, Ramesh R.   +5 more
core   +1 more source

Clusters in an intrinsically disordered protein create a protein-binding site: The TolB-binding region of colicin E9

, 2005
The 61-kDa colicin E9 protein toxin enters the cytoplasm of susceptible cells by interacting with outer membrane and periplasmic helper proteins and kills them by hydrolyzing their DNA.
Tozawa, Kaeko, Clayden, NJ, Richard James, Kleanthous, Kleanthis, Geoffrey R. Moore, Macdonald, CJ, Kaeko Tozawa, Tozawa, K, Moore, GR, James, Richard, Clayden, Nigel J., Colin Kleanthous, Colin J. Macdonald, Christopher N. Penfold, James, R, Kleanthous, C, Penfold, Christopher N., Nigel J. Clayden, Kleanthous, Colin, Macdonald, Colin J., Penfold, CN, Moore, Geoffrey R.   +21 more
core   +2 more sources

Editorial: Intrinsically Disordered Proteins and Regions: The Challenge to the Structure-Function Relationship

Frontiers in Molecular Biosciences, 2022
Angelo Toto, Pietro Sormanni, Cristina Paissoni, Vladimir N. Uversky   +3 more
doaj   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure‐Enabled Lateral Flow Assay

Advanced Healthcare Materials, EarlyView.
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao, Akhila Naru, Dhanush Gandavadi, Mengxi Zheng, Saraswathi Lanka, Hyeongjun Cho, Chau Nguyen Minh Hoang, Jianqiang Zhang, Ying Fang, Xing Wang   +9 more
wiley   +1 more source

Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation

, 2018
Significance Different combinations and permutations of transcription factors work together to regulate the expression of target genes. These proteins often contain high levels of intrinsically disordered regions, which are important mediators ...
Athina Manakas, Gordon McDonald, Ann H. Kwan, Neil O. Robertson, Ngaio C. Smith, Mahiar Mahjoub, Jacqueline M. Matthews   +6 more
core   +1 more source

An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy. [PDF]

Autophagy, 2023
Gingerich MA, Liu X, Chai B, Pearson GL, Vincent MP, Stromer T, Zhu J, Sidarala V, Renberg A, Sahu D, Klionsky DJ, Schnell S, Soleimanpour SA.   +12 more
europepmc   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Stochastic machines as a colocalization mechanism for scaffold protein function

, 2013
The axis inhibition (Axin) scaffold protein colocalizes β-catenin, casein kinase Iα, and glycogen synthetase kinase 3β by their binding to Axin’s long intrinsically disordered region, thereby yielding structured domains with flexible linkers.
Uversky, V.N., Rudiger, S.G.D., Maurice, Madelon M., Kurgan, Lukasz, Xue, B., Noutsou, Maria, Romero, P.R., Mizianty, M.J., Dunker, A.K., Cellular Protein Chemistry, Rüdiger, Stefan G. D., Uversky, Vladimir N., Sub Cellular Protein Chemistry, William, Albert M., Romero, Pedro R., Dunker, A. Keith, William, A.M. Jr., Maurice, M.M., Kurgan, L., Rüdiger, Stefan G.D., Xue, Bin, Mizianty, Marcin J., Noutsou, M., William, Albert M., Jr.   +23 more
core   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source