Results 1 to 10 of about 34,583 (113)

Expose flexible conformations for intrinsically disordered protein [PDF]

Current Research in Structural Biology
The folding conformation of native protein has flexibility in different degrees, which may bring difficulty in presenting the structures, and also it causes complexity in understanding the relationship between structure and functions.
Jiaan Yang, Wenxin Ji, Wen Xiang Cheng, Gang Wu, Si Tong Sheng, Peng Zhang, Jun Lin, Xiaojia Chen, Qiong Shi   +8 more
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Hierarchical folding-upon-binding of an intrinsically disordered protein [PDF]

Nature Communications
Intrinsically disordered proteins (IDPs) often undergo folding-upon-binding to their partners via short linear motifs, typically 5-15 amino acids in length.
Lenette F. Kjaer, Francesco S. Ielasi, Thomas Winbolt, Elise Delaforge, Maud Tengo, Luiza Mamigonian Bessa, Laura Mariño Pérez, Elisabetta Boeri Erba, Guillaume Bouvignies, Andrés Palencia, Malene Ringkjøbing Jensen   +10 more
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PUNCH2: Explore the strategy for intrinsically disordered protein predictor. [PDF]

PLoS ONE
Intrinsically disordered proteins (IDPs) and their intrinsically disordered regions (IDRs) lack stable three-dimensional structures, posing significant challenges for computational prediction.
Di Meng, Gianluca Pollastri
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Transferable deep generative modeling of intrinsically disordered protein conformations. [PDF]

PLoS Computational Biology
Intrinsically disordered proteins have dynamic structures through which they play key biological roles. The elucidation of their conformational ensembles is a challenging problem requiring an integrated use of computational and experimental methods ...
Giacomo Janson, Michael Feig
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Synthetic intrinsically disordered protein fusion tags that enhance protein solubility [PDF]

Nature Communications
We report the de novo design of small (
Nicholas C. Tang, Jonathan C. Su, Yulia Shmidov, Garrett Kelly, Sonal Deshpande, Parul Sirohi, Nikhil Peterson, Ashutosh Chilkoti   +7 more
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Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics

Biomolecules, 2022
Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every year. Once a rabies patient has become symptomatic, there is no effective treatment for the illness, and in unvaccinated individuals, the case-fatality rate of rabies is ...
Surya Dhulipala, Vladimir N. Uversky
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Prediction of folding patterns for intrinsic disordered protein

Scientific Reports, 2023
The conformation flexibility of natural protein causes both complexity and difficulty to understand the relationship between structure and function. The prediction of intrinsically disordered protein primarily is focusing on to disclose the regions with ...
Jiaan Yang, Wen-xiang Cheng, Gang Wu, Sitong Sheng, Peng Zhang   +4 more
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Differences in the number of intrinsically disordered regions between yeast duplicated proteins, and their relationship with functional divergence. [PDF]

PLoS ONE, 2011
BACKGROUND: Intrinsically disordered regions are enriched in short interaction motifs that play a critical role in many protein-protein interactions. Since new short interaction motifs may easily evolve, they have the potential to rapidly change protein ...
Floriane Montanari, Denis C Shields, Nora Khaldi   +2 more
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Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins

Biomolecules, 2020
Direct interaction between intrinsically disordered proteins (IDPs) is often difficult to characterize hampering the elucidation of their binding mechanism.
Maria Grazia Murrali, Isabella C. Felli, Roberta Pierattelli   +2 more
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Intrinsically disordered regions in TRPV2 mediate protein-protein interactions

Communications Biology, 2023
Transient receptor potential (TRP) ion channels are gated by diverse intra- and extracellular stimuli leading to cation inflow (Na+, Ca2+) regulating many cellular processes and initiating organismic somatosensation.
Raghavendar R. Sanganna Gari, Grigory Tagiltsev, Ruth A. Pumroy, Yining Jiang, Martin Blackledge, Vera Y. Moiseenkova-Bell, Simon Scheuring   +6 more
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