Results 1 to 10 of about 7,902,914 (332)

Deciphering How Clustered O‑Glycosylation Shapes Substrate-Binding Preferences in an Intrinsically Disordered Protein Region [PDF]

JACS Au
Post-translational modifications such as clustered O-glycosylation are frequently enriched in intrinsically disordered regions (IDRs), yet their roles in shaping molecular behavior and functional specificity remain poorly understood.
Ruihan Wang, Wenqiang Liu, Xin Li, Yajing Zhang, Jiekang Tian, Huanjie Zhu, Zerun Song, Chunyu Jin, Yaohao Li, Dingguo Xu, Shiying Shang, Zhongping Tan   +11 more
doaj   +3 more sources

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies

Biomolecules, 2021
Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation.
Bálint Mészáros, Borbála Hajdu-Soltész, András Zeke, Zsuzsanna Dosztányi   +3 more
doaj   +4 more sources

Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy complex depends on an intrinsically disordered protein region. [PDF]

J Biol Chem, 2023
CLEC16A is an E3 ubiquitin ligase that regulates mitochondrial quality control through mitophagy and is associated with over 20 human diseases. CLEC16A forms a complex with another E3 ligase, RNF41, and a ubiquitin-specific peptidase, USP8; however ...
Morgan A. Gingerich, Jie Zhu, Biao-Xin Chai, Michael Vincent, Nu-Li Xie, Vaibhav Sidarala, Nicholas A. Kotov, Debashish Sahu, D. Klionsky, Santiago Schnell, S. Soleimanpour   +10 more
semanticscholar   +2 more sources

Intrinsically disordered protein, DNA binding with one finger transcription factor (OsDOF27) implicates thermotolerance in yeast and rice

Frontiers in Plant Science, 2022
Intrinsically disorder regions or proteins (IDRs or IDPs) constitute a large subset of the eukaryotic proteome, which challenges the protein structure–function paradigm.
Nishu Gandass, Kajal, Prafull Salvi
doaj   +2 more sources

Abelson kinase’s intrinsically disordered region plays essential roles in protein function and protein stability

Cell Communication and Signaling, 2021
Background The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy.
Edward M. Rogers, S. Colby Allred, Mark Peifer   +2 more
doaj   +2 more sources

Intra- and inter-molecular regulation by intrinsically-disordered regions governs PUF protein RNA binding

Nature Communications, 2023
PUF proteins are characterized by globular RNA-binding domains. They also interact with partner proteins that modulate their RNA-binding activities. Caenorhabditis elegans PUF protein fem-3 binding factor-2 (FBF-2) partners with intrinsically disordered ...
Chen Qiu, Zihan Zhang, Robert N. Wine, Zachary T. Campbell, Jun Zhang, Traci M. Tanaka Hall   +5 more
doaj   +2 more sources

Intrinsically Disordered Protein TEX264 Mediates ER-Phagy

Molecular Cell, 2019
Certain proteins and organelles can be selectively degraded by autophagy. Typical substrates and receptors of selective autophagy have LC3-interacting regions (LIRs) that bind to autophagosomal LC3 and GABARAP family proteins.
Tohru Natsume, Mizushima Noboru, Haruka Chino   +2 more
exaly   +2 more sources

Editorial: Intrinsically Disordered Proteins and Regions: The Challenge to the Structure-Function Relationship

Frontiers in Molecular Biosciences, 2022
Angelo Toto, Pietro Sormanni, Cristina Paissoni, Vladimir N. Uversky   +3 more
doaj   +3 more sources

Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics

Biomolecules, 2022
Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every year. Once a rabies patient has become symptomatic, there is no effective treatment for the illness, and in unvaccinated individuals, the case-fatality rate of rabies is ...
Surya Dhulipala, Vladimir N. Uversky
doaj   +1 more source

Testing the length limit of loop grafting in a helical repeat protein

Current Research in Structural Biology, 2021
Alpha-helical repeat proteins such as consensus-designed tetratricopeptide repeats (CTPRs) are exceptionally stable molecules that are able to tolerate destabilizing sequence alterations and are therefore becoming increasingly valued as a modular ...
Juliane F. Ripka, Albert Perez-Riba, Piyush K. Chaturbedy, Laura S. Itzhaki   +3 more
doaj   +1 more source