Results 1 to 10 of about 29,265 (113)

Theater in the Self-Cleaning Cell: Intrinsically Disordered Proteins or Protein Regions Acting with Membranes in Autophagy

Membranes, 2022
Intrinsically disordered proteins and protein regions (IDPs/IDPRs) are mainly involved in signaling pathways, where fast regulation, temporal interactions, promiscuous interactions, and assemblies of structurally diverse components including membranes ...
Hana Popelka, Vladimir N. Uversky
doaj   +3 more sources

Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy complex depends on an intrinsically disordered protein region. [PDF]

J Biol Chem, 2023
Gingerich MA, Zhu J, Chai B, Vincent MP, Xie N, Sidarala V, Kotov NA, Sahu D, Klionsky DJ, Schnell S, Soleimanpour SA.   +10 more
europepmc   +2 more sources

A New Anatomy of Autophagic Clearance: On the Roles of Intrinsic Disorder in the Membrane-Less on Membrane-Encapsulated Mechanism [PDF]

Membranes
Autophagy is a carefully regulated catabolic process that utilizes assemblies of specific sets of macromolecules operating at multiple stages of the pathway.
Vladimir N. Uversky, Hana Popelka, Daniel J. Klionsky   +2 more
doaj   +2 more sources

Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics

Frontiers in Physics, 2019
Recognition of the natural abundance and functional importance of intrinsically disordered proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions (IDPRs) and ordered regions, is changing protein science.
Vladimir N. Uversky, Vladimir N. Uversky
doaj   +3 more sources

A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src

Cell Reports, 2018
Summary: The mode of regulation of Src kinases has been elucidated by crystallographic studies identifying conserved structured protein modules involved in an orderly set of intramolecular associations and ligand interactions.
Danislav S. Spassov, Ana Ruiz-Saenz, Amit Piple, Mark M. Moasser   +3 more
doaj   +3 more sources

IDP⁻CRF: Intrinsically Disordered Protein/Region Identification Based on Conditional Random Fields. [PDF]

Int J Mol Sci, 2018
Liu Y, Wang X, Liu B.
europepmc   +2 more sources

Deciphering How Clustered O‑Glycosylation Shapes Substrate-Binding Preferences in an Intrinsically Disordered Protein Region [PDF]

JACS Au
Ruihan Wang, Wenqiang Liu, Xin Li, Yajing Zhang, Jiekang Tian, Huanjie Zhu, Zerun Song, Chunyu Jin, Yaohao Li, Dingguo Xu, Shiying Shang, Zhongping Tan   +11 more
doaj   +2 more sources

Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics

Biomolecules, 2022
Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every year. Once a rabies patient has become symptomatic, there is no effective treatment for the illness, and in unvaccinated individuals, the case-fatality rate of rabies is ...
Surya Dhulipala, Vladimir N. Uversky
doaj   +1 more source

Testing the length limit of loop grafting in a helical repeat protein

Current Research in Structural Biology, 2021
Alpha-helical repeat proteins such as consensus-designed tetratricopeptide repeats (CTPRs) are exceptionally stable molecules that are able to tolerate destabilizing sequence alterations and are therefore becoming increasingly valued as a modular ...
Juliane F. Ripka, Albert Perez-Riba, Piyush K. Chaturbedy, Laura S. Itzhaki   +3 more
doaj   +1 more source

Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins

Biomolecules, 2020
Direct interaction between intrinsically disordered proteins (IDPs) is often difficult to characterize hampering the elucidation of their binding mechanism.
Maria Grazia Murrali, Isabella C. Felli, Roberta Pierattelli   +2 more
doaj   +1 more source