Results 1 to 10 of about 27,918 (118)

Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy complex depends on an intrinsically disordered protein region. [PDF]

J Biol Chem, 2023
Gingerich MA, Zhu J, Chai B, Vincent MP, Xie N, Sidarala V, Kotov NA, Sahu D, Klionsky DJ, Schnell S, Soleimanpour SA.   +10 more
europepmc   +2 more sources

Deciphering How Clustered O‑Glycosylation Shapes Substrate-Binding Preferences in an Intrinsically Disordered Protein Region [PDF]

JACS Au
Ruihan Wang, Wenqiang Liu, Xin Li, Yajing Zhang, Jiekang Tian, Huanjie Zhu, Zerun Song, Chunyu Jin, Yaohao Li, Dingguo Xu, Shiying Shang, Zhongping Tan   +11 more
doaj   +2 more sources

Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics

Biomolecules, 2022
Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every year. Once a rabies patient has become symptomatic, there is no effective treatment for the illness, and in unvaccinated individuals, the case-fatality rate of rabies is ...
Surya Dhulipala, Vladimir N. Uversky
doaj   +1 more source

Testing the length limit of loop grafting in a helical repeat protein

Current Research in Structural Biology, 2021
Alpha-helical repeat proteins such as consensus-designed tetratricopeptide repeats (CTPRs) are exceptionally stable molecules that are able to tolerate destabilizing sequence alterations and are therefore becoming increasingly valued as a modular ...
Juliane F. Ripka, Albert Perez-Riba, Piyush K. Chaturbedy, Laura S. Itzhaki   +3 more
doaj   +1 more source

Theater in the Self-Cleaning Cell: Intrinsically Disordered Proteins or Protein Regions Acting with Membranes in Autophagy

Membranes, 2022
Intrinsically disordered proteins and protein regions (IDPs/IDPRs) are mainly involved in signaling pathways, where fast regulation, temporal interactions, promiscuous interactions, and assemblies of structurally diverse components including membranes ...
Hana Popelka, Vladimir N. Uversky
doaj   +1 more source

Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins

Biomolecules, 2020
Direct interaction between intrinsically disordered proteins (IDPs) is often difficult to characterize hampering the elucidation of their binding mechanism.
Maria Grazia Murrali, Isabella C. Felli, Roberta Pierattelli   +2 more
doaj   +1 more source

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Nature Communications, 2021
The SARS-CoV-2 nucleocapsid (N) protein binds the viral RNA genome and contains two ordered domains flanked by three intrinsically-disordered regions. Here, the authors show that RNA binding induces liquid-liquid phase separation of N, which is driven by
Shan Lu, Qiaozhen Ye, Digvijay Singh, Yong Cao, Jolene K. Diedrich, John R. Yates, Elizabeth Villa, Don W. Cleveland, Kevin D. Corbett   +8 more
doaj   +1 more source

Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid

Journal of Genetic Engineering and Biotechnology, 2023
Background Hepatitis E virus (HEV) is the cause of a liver disease hepatitis E. The translation product of HEV ORF2 has recently been demonstrated as a protein involved in multiple functions besides performing its major role of a viral capsid.
Zoya Shafat, Anwar Ahmed, Mohammad K. Parvez, Shama Parveen   +3 more
doaj   +1 more source

Intrinsic Disorder as a Natural Preservative: High Levels of Intrinsic Disorder in Proteins Found in the 2600-Year-Old Human Brain

Biology, 2022
Proteomic analysis revealed the preservation of many proteins in the Heslington brain (which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 from a pit in Heslington, Yorkshire, England).
Aaron S. Mohammed, Vladimir N. Uversky
doaj   +1 more source

Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions

Molecules, 2017
Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive ...
April L. Darling, Vladimir N. Uversky
doaj   +1 more source