Results 21 to 30 of about 29,414 (258)
Intrinsically disordered regions in TRPV2 mediate protein-protein interactions
Communications Biology, 2023 AbstractTransient receptor potential (TRP) ion channels are gated by diverse intra- and extracellular stimuli leading to cation inflow (Na+, Ca2+) regulating many cellular processes and initiating organismic somatosensation. Structures of most TRP channels have been solved.
Sanganna Gari, Raghavendar +6 more
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Analysis of structured and intrinsically disordered regions of transmembrane proteins [PDF]
Molecular BioSystems, 2009 Abstract Integral membraneproteins display two major types of transmembrane structure, helical bundles and beta barrels. The main functional roles of transmembrane proteins are the transport of small molecules and cellsignaling, and sometimes these two roles are coupled.
Xue, Bin +4 more
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Journal of Genetic Engineering and Biotechnology, 2023 Background Hepatitis E virus (HEV) is the cause of a liver disease hepatitis E. The translation product of HEV ORF2 has recently been demonstrated as a protein involved in multiple functions besides performing its major role of a viral capsid.
Zoya Shafat +3 more
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Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
Molecules, 2017 Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive ...
April L. Darling, Vladimir N. Uversky
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Biology, 2022 Proteomic analysis revealed the preservation of many proteins in the Heslington brain (which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 from a pit in Heslington, Yorkshire, England).
Aaron S. Mohammed, Vladimir N. Uversky
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On the roles of intrinsically disordered proteins and regions in cell communication and signaling [PDF]
Cell Communication and Signaling, 2021 AbstractFor proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured proteins, intrinsically disordered proteins and regions (IDPs and IDRs) also carry out crucial biological functions. For these proteins, the
Bondos, Sarah E. +2 more
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Biophysics and Physicobiology, 2020 Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically disordered regions.
Hiroto Anbo +2 more
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The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock
Cell Communication and Signaling, 2020 Cryptochrome (CRY) proteins play an essential role in regulating mammalian circadian rhythms. CRY is composed of a structured N-terminal domain known as the photolyase homology region (PHR), which is tethered to an intrinsically disordered C-terminal ...
Gian Carlo G. Parico, Carrie L. Partch
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Communications Biology, 2023 Evolution-guided mutagenesis and biophysical analysis reveal that residual helical structure in the binding region of an intrinsically disordered protein regulates the lifetime of its complex by affecting its dissociation.
Steffie Elkjær +6 more
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Biology, 2022 In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs).
Elrashdy M. Redwan +2 more
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