Results 11 to 20 of about 29,703 (304)
Sequence complexity of amyloidogenic regions in intrinsically disordered human proteins.
PLoS ONE, 2014 An amyloidogenic region (AR) in a protein sequence plays a significant role in protein aggregation and amyloid formation. We have investigated the sequence complexity of AR that is present in intrinsically disordered human proteins.
Swagata Das +6 more
doaj +4 more sources
Expanded Interactome of the Intrinsically Disordered Protein Dss1 [PDF]
Cell Reports, 2018 Summary: Dss1 (also known as Sem1) is a conserved, intrinsically disordered protein with a remarkably broad functional diversity. It is a proteasome subunit but also associates with the BRCA2, RPA, Csn12-Thp1, and TREX-2 complexes.
Signe M. Schenstrøm +7 more
doaj +2 more sources
DisoMCS: Accurately Predicting Protein Intrinsically Disordered Regions Using a Multi-Class Conservative Score Approach. [PDF]
PLoS ONE, 2015 The precise prediction of protein intrinsically disordered regions, which play a crucial role in biological procedures, is a necessary prerequisite to further the understanding of the principles and mechanisms of protein function.
Zhiheng Wang +3 more
doaj +2 more sources
Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies [PDF]
Biomolecules, 2021 Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation.
Bálint Mészáros +3 more
doaj +2 more sources
Rapid evolution of virus sequences in intrinsically disordered protein regions. [PDF]
PLoS Pathogens, 2014 Nodamura Virus (NoV) is a nodavirus originally isolated from insects that can replicate in a wide variety of hosts, including mammals. Because of their simplicity and ability to replicate in many diverse hosts, NoV, and the Nodaviridae in general ...
Leonid Gitlin +14 more
core +6 more sources
Accurate Prediction of Drug Resistance for Intrinsically Disordered Protein Regions [PDF]
Journal of Chemical Theory and ComputationRelative alchemical binding free energy calculations can be used to predict the effect of amino acid mutations on ligand binding affinities. However, these protocols are not well established for proteins containing intrinsically disordered regions (IDRs).
Michel, Julien +2 more
core +3 more sources
IDP⁻CRF: Intrinsically Disordered Protein/Region Identification Based on Conditional Random Fields. [PDF]
Int J Mol Sci, 2018 Accurate prediction of intrinsically disordered proteins/regions is one of the most important tasks in bioinformatics, and some computational predictors have been proposed to solve this problem. How to efficiently incorporate the sequence-order effect is
Liu Y, Wang X, Liu B.
europepmc +2 more sources
Biophysical Reviews, 2022 Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based ...
Orkid Coskuner-Weber +2 more
openaire +4 more sources
Intrinsically disordered regions in autophagy proteins [PDF]
Proteins: Structure, Function, and Bioinformatics, 2013 ABSTRACTAutophagy is an essential eukaryotic pathway required for cellular homeostasis. Numerous key autophagy effectors and regulators have been identified, but the mechanism by which they carry out their function in autophagy is not fully understood.
Yang, Mei +5 more
openaire +2 more sources
Phosphorylation of Intrinsically Disordered Regions in Remorin Proteins [PDF]
Frontiers in Plant Science, 2012 Plant-specific remorin proteins reside in subdomains of plasma membranes, originally termed membrane rafts. They probably facilitate cellular signal transduction by direct interaction with signaling proteins such as receptor-like kinases and may dynamically modulate their lateral segregation within plasma membranes.
Marín, Macarena, Ott, Thomas
openaire +5 more sources