Results 31 to 40 of about 29,414 (258)

Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL

Communications Biology, 2023
Dynamic docking simulations reveal the interactions and conformational changes of the intrinsically disordered region of Bim and its cryptic binding site in Bcl-xL, a pro-survival protein involved in cancer progression.
Gert-Jan Bekker, Mitsugu Araki, Kanji Oshima, Yasushi Okuno, Narutoshi Kamiya   +4 more
doaj   +1 more source

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

Cell Reports, 2020
Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by
Arndt Pechstein, Nikolay Tomilin, Kristin Fredrich, Olga Vorontsova, Elena Sopova, Emma Evergren, Volker Haucke, Lennart Brodin, Oleg Shupliakov   +8 more
doaj   +1 more source

DisoMCS: Accurately Predicting Protein Intrinsically Disordered Regions Using a Multi-Class Conservative Score Approach. [PDF]

PLoS ONE, 2015
The precise prediction of protein intrinsically disordered regions, which play a crucial role in biological procedures, is a necessary prerequisite to further the understanding of the principles and mechanisms of protein function.
Zhiheng Wang, Qianqian Yang, Tonghua Li, Peisheng Cong   +3 more
doaj   +1 more source

Fuzzy regions in an intrinsically disordered protein impair protein–protein interactions [PDF]

The FEBS Journal, 2016
Despite the partial disorder‐to‐order transition that intrinsically disordered proteins often undergo upon binding to their partners, a considerable amount of residual disorder may be retained in the bound form, resulting in a fuzzy complex.
Gruet, Antoine, Dosnon, Marion, Blocquel, David, Brunel, Joanna, Gerlier, Denis, Das, Rahul K., Bonetti, Daniela, Gianni, Stefano, Fuxreiter, Monika, Longhi, Sonia, Bignon, Christophe   +10 more
openaire   +5 more sources

Cryptic amyloidogenic regions in intrinsically disordered proteins

Computational and Structural Biotechnology Journal, 2021
The amyloid conformation is considered a fundamental state of proteins and the propensity to populate it a generic property of polypeptides. Multiple proteome-wide analyses addressed the presence of amyloidogenic regions in proteins, nurturing our understanding of their nature and biological implications.
Santos, Jaime||, Pallarès i Goitiz, Irantzu||, Iglesias, Valentin||, Ventura, Salvador||   +3 more
openaire   +5 more sources

Expanded Interactome of the Intrinsically Disordered Protein Dss1

Cell Reports, 2018
Summary: Dss1 (also known as Sem1) is a conserved, intrinsically disordered protein with a remarkably broad functional diversity. It is a proteasome subunit but also associates with the BRCA2, RPA, Csn12-Thp1, and TREX-2 complexes.
Signe M. Schenstrøm, Caio A. Rebula, Michael H. Tatham, Ruth Hendus-Altenburger, Isabelle Jourdain, Ronald T. Hay, Birthe B. Kragelund, Rasmus Hartmann-Petersen   +7 more
doaj   +1 more source

Many-to-one binding by intrinsically disordered protein regions

Biocomputing 2020, 2019
Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions. DBR-protein complexes were collected from the Protein Data Bank for which two or more DBRs having different amino acid sequences bind to the same (100% sequence ...
Alterovitz, Wei-Lun, Faraggi, Eshel, Oldfield, Christopher J., Meng, Jingwei, Xue, Bin, Huang, Fei, Romero, Pedro, Kloczkowski, Andrzej, Uversky, Vladimir N., Dunker, A. Keith   +9 more
openaire   +4 more sources

Order, Disorder, and Everything in Between

Molecules, 2016
In addition to the “traditional” proteins characterized by the unique crystal-like structures needed for unique functions, it is increasingly recognized that many proteins or protein regions (collectively known as intrinsically disordered proteins (IDPs)
Shelly DeForte, Vladimir N. Uversky
doaj   +1 more source

Abelson kinase’s intrinsically disordered region plays essential roles in protein function and protein stability

Cell Communication and Signaling, 2021
Background The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy.
Edward M. Rogers, S. Colby Allred, Mark Peifer   +2 more
doaj   +1 more source

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies

Biomolecules, 2021
Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation.
Bálint Mészáros, Borbála Hajdu-Soltész, András Zeke, Zsuzsanna Dosztányi   +3 more
doaj   +1 more source