Results 31 to 40 of about 29,703 (304)

Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors

Biology, 2022
In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs).
Elrashdy M. Redwan, Abdullah A. Aljadawi, Vladimir N. Uversky   +2 more
doaj   +1 more source

NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences

Biophysics and Physicobiology, 2020
Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis­ordered regions.
Hiroto Anbo, Hiroki Amagai, Satoshi Fukuchi   +2 more
doaj   +1 more source

Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL

Communications Biology, 2023
Dynamic docking simulations reveal the interactions and conformational changes of the intrinsically disordered region of Bim and its cryptic binding site in Bcl-xL, a pro-survival protein involved in cancer progression.
Gert-Jan Bekker, Mitsugu Araki, Kanji Oshima, Yasushi Okuno, Narutoshi Kamiya   +4 more
doaj   +1 more source

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

Cell Reports, 2020
Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by
Arndt Pechstein, Nikolay Tomilin, Kristin Fredrich, Olga Vorontsova, Elena Sopova, Emma Evergren, Volker Haucke, Lennart Brodin, Oleg Shupliakov   +8 more
doaj   +1 more source

Fuzzy regions in an intrinsically disordered protein impair protein–protein interactions [PDF]

The FEBS Journal, 2016
Despite the partial disorder‐to‐order transition that intrinsically disordered proteins often undergo upon binding to their partners, a considerable amount of residual disorder may be retained in the bound form, resulting in a fuzzy complex.
Gruet, Antoine, Dosnon, Marion, Blocquel, David, Brunel, Joanna, Gerlier, Denis, Das, Rahul K., Bonetti, Daniela, Gianni, Stefano, Fuxreiter, Monika, Longhi, Sonia, Bignon, Christophe   +10 more
openaire   +5 more sources

Cryptic amyloidogenic regions in intrinsically disordered proteins

Computational and Structural Biotechnology Journal, 2021
The amyloid conformation is considered a fundamental state of proteins and the propensity to populate it a generic property of polypeptides. Multiple proteome-wide analyses addressed the presence of amyloidogenic regions in proteins, nurturing our understanding of their nature and biological implications.
Santos, Jaime||, Pallarès i Goitiz, Irantzu||, Iglesias, Valentin||, Ventura, Salvador||   +3 more
openaire   +5 more sources

Abelson kinase’s intrinsically disordered region plays essential roles in protein function and protein stability

Cell Communication and Signaling, 2021
Background The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy.
Edward M. Rogers, S. Colby Allred, Mark Peifer   +2 more
doaj   +1 more source

Order, Disorder, and Everything in Between

Molecules, 2016
In addition to the “traditional” proteins characterized by the unique crystal-like structures needed for unique functions, it is increasingly recognized that many proteins or protein regions (collectively known as intrinsically disordered proteins (IDPs)
Shelly DeForte, Vladimir N. Uversky
doaj   +1 more source

Intrinsic Disorder of the C-Terminal Domain of Drosophila Methoprene-Tolerant Protein. [PDF]

PLoS ONE, 2016
Methoprene tolerant protein (Met) has recently been confirmed as the long-sought juvenile hormone (JH) receptor. This protein plays a significant role in the cross-talk of the 20-hydroxyecdysone (20E) and JH signalling pathways, which are important for ...
Marta Kolonko, Katarzyna Ożga, Rafał Hołubowicz, Michał Taube, Maciej Kozak, Andrzej Ożyhar, Beata Greb-Markiewicz   +6 more
doaj   +1 more source

Dss1 Is a 26S Proteasome Ubiquitin Receptor [PDF]

, 2014
The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome.
Hardwick, Kevin G., Hay, Ronald T., Larsen, Ida B., Kragelund, Birthe B., Tatham, Michael H, Rösner, Heike I, Kragelund, Birthe Brandt, Hay, Ronald T, Kragelund, Birthe B, Kriegenburg, Franziska, Tatham, Michael H., Rösner, Heike Ilona, Paraskevopoulos, Konstantinos, Brandstrup, Rikke, Larsen, Ida B, Medina, Bethan; id_orcid, Hartmann-Petersen, Rasmus, Gordon, Colin, Rösner, Heike I., Hardwick, Kevin G, Medina, Bethan   +20 more
core   +1 more source