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Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders [PDF]

Frontiers in Aging Neuroscience, 2015
The recent years have witnessed a rise in the number of intrinsically disor-dered proteins (IDPs), also known as hybrid proteins, which possess both struc-tured domains and biologically important intrinsically disordered protein regions (IDPRs).
Vladimir N. Uversky, Vladimir N. Uversky, Vladimir N. Uversky, Vladimir N. Uversky   +3 more
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Mapping Charge Interactions in Intrinsically Disordered Proteins [PDF]

Advanced Science
Intrinsically disordered proteins (IDPs) are often rich in charged residues, and electrostatic interactions have a pronounced effect on their conformational distributions, interactions and functions.
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
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A membrane insertion code for intrinsically disordered proteins [PDF]

eLife
Membrane association of intrinsically disordered proteins (IDPs) mediates various cellular functions including membrane remodeling and signal transduction.
Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou   +1 more
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Transient tertiary structure in intrinsically disordered proteins revealed by multithermal enhanced sampling [PDF]

Nature Communications
Intrinsically disordered proteins populate heterogeneous conformational ensembles that are challenging to characterise. While all-atom molecular dynamics simulations can provide detailed insights into dynamic ensembles, achieving sufficient sampling ...
Julian O. Streit, Michele Invernizzi, Sandro Bottaro, Kamil Tamiola, Kresten Lindorff-Larsen   +4 more
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IDPsBind: a repository of binding sites for intrinsically disordered proteins complexes with known 3D structures

BMC Molecular and Cell Biology, 2022
Background Intrinsically disordered proteins (IDPs) lack a stable three-dimensional structure under physiological conditions but play crucial roles in many biological processes.
CanZhuang Sun, YongE Feng, GuoLiang Fan
doaj   +1 more source

Investigating Intrinsically Disordered Proteins With Brownian Dynamics

Frontiers in Molecular Biosciences, 2022
Intrinsically disordered proteins (IDPs) have recently become systems of great interest due to their involvement in modulating many biological processes and their aggregation being implicated in many diseases.
Surl-Hee Ahn, Gary A. Huber, Gary A. Huber, J. Andrew McCammon, J. Andrew McCammon   +4 more
doaj   +1 more source

idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R

PLoS ONE, 2022
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are proteins or protein-domains that do not have a single native structure, rather, they are a class of flexible peptides that can rapidly adopt multiple conformations ...
William M. McFadden, Judith L. Yanowitz
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Adenoviral E1A Exploits Flexibility and Disorder to Target Cellular Proteins

Biomolecules, 2020
Direct interaction between intrinsically disordered proteins (IDPs) is often difficult to characterize hampering the elucidation of their binding mechanism.
Maria Grazia Murrali, Isabella C. Felli, Roberta Pierattelli   +2 more
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Evolutionary Study of Disorder in Protein Sequences

Biomolecules, 2020
Intrinsically disordered proteins (IDPs) contain regions lacking intrinsic globular structure (intrinsically disordered regions, IDRs). IDPs are present across the tree of life, with great variability of IDR type and frequency even between closely ...
Kristina Kastano, Gábor Erdős, Pablo Mier, Gregorio Alanis-Lobato, Vasilis J. Promponas, Zsuzsanna Dosztányi, Miguel A. Andrade-Navarro   +6 more
doaj   +1 more source

NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences

Biophysics and Physicobiology, 2020
Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis­ordered regions.
Hiroto Anbo, Hiroki Amagai, Satoshi Fukuchi   +2 more
doaj   +1 more source