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Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs) [PDF]
Chemical Reviews, 2014 It has long been axiomatic that a protein’s structure determines its function. Intrinsically disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure–function paradigm.
François-Xavier Theillet +2 more
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Brain Expressed and X-Linked (Bex) Proteins Are Intrinsically Disordered Proteins (IDPs) and Form New Signaling Hubs [PDF]
PLoS ONE, 2015 Intrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation.
Marcal Vilar
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Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs) [PDF]
International Journal of Molecular Sciences, 2011 Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions.
Zanxia Cao, Zhao Liling
exaly +3 more sources
Intrinsically disordered proteins (IDPs) in trypanosomatids. [PDF]
BMC Genomics, 2014 Proteins are composed of one or more amino acid chains and exhibit several structure levels. IDPs (intrinsically disordered proteins) represent a class of proteins that do not fold into any particular conformation and exist as dynamic ensembles in their ...
de Cássia Ruy P +5 more
europepmc +2 more sources
Communications Biology, 2023 Intrinsically disordered proteins (IDPs) are comprised of significant numbers of residues that form neither helix, sheet, nor any other canonical type of secondary structure.
Andrew J. Miles +2 more
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Frontiers in Aging Neuroscience, 2022 Protein structure is determined by the amino acid sequence and a variety of post-translational modifications, and provides the basis for physiological properties.
Akshatha Ganne +7 more
doaj +3 more sources
BMC BiologyIntrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders.
Caolitao Qin +4 more
doaj +2 more sources
Sequence-encoded differences in the conformational ensembles of CITED transcriptional activation domains impact coactivator binding. [PDF]
Protein SciAbstract Recent advances in predicting and modeling conformational ensembles of intrinsically disordered proteins (IDPs) have provided much needed insights into sequence‐ensemble relationships. It is thought that conservation of physicochemical properties, but not the exact identity or order of the amino acids, maintains IDP ensemble properties that ...
Do TU +4 more
europepmc +2 more sources
PLoS ONE, 2019 Many studies about classification and the functional annotation of intrinsically disordered proteins (IDPs) are based on either the occurrence of long disordered regions or the fraction of disordered residues in the sequence.
Antonio Deiana +3 more
doaj +2 more sources
Atomic resolution ensembles of intrinsically disordered proteins with Alphafold. [PDF]
Nat CommunIntrinsically disordered proteins are ubiquitous in biological systems and play essential roles in a wide range of biological processes and diseases.
Schnapka V +3 more
europepmc +2 more sources