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Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). [PDF]
Chem Rev, 2014 It has long been axiomatic that a protein’s structure determines its function. Intrinsically disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure–function paradigm.
Theillet FX +12 more
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Intrinsically disordered proteins (IDPs) in trypanosomatids. [PDF]
BMC Genomics, 2014 Proteins are composed of one or more amino acid chains and exhibit several structure levels. IDPs (intrinsically disordered proteins) represent a class of proteins that do not fold into any particular conformation and exist as dynamic ensembles in their ...
de Cássia Ruy P +5 more
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Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs) [PDF]
International Journal of Molecular Sciences, 2011 Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions.
Liling Zhao, Zanxia Cao, Jihua Wang
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Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs. [PDF]
PLoS One, 2015 Intrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation.
Fernandez EM, Díaz-Ceso MD, Vilar M.
europepmc +7 more sources
Communications Biology, 2023 Intrinsically disordered proteins (IDPs) are comprised of significant numbers of residues that form neither helix, sheet, nor any other canonical type of secondary structure.
Andrew J. Miles +2 more
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BMC BiologyIntrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders.
Caolitao Qin +4 more
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PLoS ONE, 2019 Many studies about classification and the functional annotation of intrinsically disordered proteins (IDPs) are based on either the occurrence of long disordered regions or the fraction of disordered residues in the sequence.
Antonio Deiana +3 more
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Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics
Frontiers in Physics, 2019 Recognition of the natural abundance and functional importance of intrinsically disordered proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions (IDPRs) and ordered regions, is changing protein science.
Vladimir N. Uversky, Vladimir N. Uversky
doaj +3 more sources
Embrace Disorder as a Function: Bio-Informed Biomaterials Design Advanced by Intrinsically Disordered Proteins [PDF]
BiomimeticsThe “lock and key” model of molecular recognition, anchored by the canonical sequence–structure–function paradigm, has successfully served as a basis for designing biomimetic biomaterials for decades.
Candan Tamerler, Malcolm L. Snead
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Current Research in Structural BiologyEukaryotic proteins often feature long stretches of amino acids that lack a well-defined three-dimensional structure and are referred to as intrinsically disordered proteins (IDPs) or regions (IDRs).
Snigdha Maiti +4 more
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