Results 11 to 20 of about 23,171 (195)

INTRINSICALLY DISORDERED PROTEINS (IDPS) IN HUMAN DISEASES: A REVIEW

International Research Journal Of Pharmacy, 2018
Biologically active proteins without stable tertiary structure are called Intrinsically Disordered Proteins (IDPs) or Intrinsically Unstructured Proteins (IUPs).
Divya Shaji
semanticscholar   +2 more sources

IDP-Bert: Predicting Properties of Intrinsically Disordered Proteins Using Large Language Models [PDF]

The Journal of Physical Chemistry B
Intrinsically disordered Proteins (IDPs) constitute a large and structureless class of proteins with significant functions. The existence of IDPs challenges the conventional notion that the biological functions of proteins rely on their three-dimensional
Parisa Mollaei, Danush Sadasivam, Chakradhar Guntuboina, Amir Barati Farimani   +3 more
semanticscholar   +4 more sources

Conformationally adaptive therapeutic peptides for diseases caused by intrinsically disordered proteins (IDPs). New paradigm for drug discovery: Target the target, not the arrow.

Pharmacology & Therapeutics
The traditional model of protein structure determined by the amino acid sequence is today seriously challenged by the fact that approximately half of the human proteome is made up of proteins that do not have a stable 3D structure, either partially or in
Jacques Fantini, F. Azzaz, C. Di Scala, Anaïs Aulas, H. Chahinian, N. Yahi   +5 more
semanticscholar   +6 more sources

Spontaneous Switching among Conformational Ensembles in Intrinsically Disordered Proteins

Biomolecules, 2019
The common conception of intrinsically disordered proteins (IDPs) is that they stochastically sample all possible configurations driven by thermal fluctuations.
Ucheor B. Choi, Hugo Sanabria, Tatyana Smirnova, Mark E. Bowen, Keith R. Weninger   +4 more
doaj   +3 more sources

Intrinsically disordered proteins studied by NMR spectroscopy

Journal of Magnetic Resonance Open
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of complex multi-domain proteins are now identified as a trend topic by the scientific community.
Marco Schiavina, Lorenzo Bracaglia, Tessa Bolognesi, Maria Anna Rodella, Giuseppe Tagliaferro, Angela Sofia Tino, Roberta Pierattelli, Isabella C. Felli   +7 more
doaj   +3 more sources

idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R

PLoS ONE, 2022
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are proteins or protein-domains that do not have a single native structure, rather, they are a class of flexible peptides that can rapidly adopt multiple conformations ...
William M. McFadden, Judith L. Yanowitz
doaj   +3 more sources

Faculty Opinions recommendation of Intrinsically disordered proteins (IDPs) in trypanosomatids.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2015
V. Uversky
semanticscholar   +2 more sources

Polymer Concepts in Cellular Function. [PDF]

Adv Sci (Weinh)
Advanced Science, EarlyView.
Yu M, Dhiman S, Dormann D, Gräter F, Luck K, Schmid F, Walther A, Lemke EA.   +7 more
europepmc   +2 more sources

Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation

Frontiers in Aging Neuroscience, 2022
Protein structure is determined by the amino acid sequence and a variety of post-translational modifications, and provides the basis for physiological properties.
Akshatha Ganne, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Srinivas Ayyadevara, Srinivas Ayyadevara, Robert J. Shmookler Reis, Robert J. Shmookler Reis, Robert J. Shmookler Reis   +7 more
doaj   +1 more source

IDPsBind: a repository of binding sites for intrinsically disordered proteins complexes with known 3D structures

BMC Molecular and Cell Biology, 2022
Background Intrinsically disordered proteins (IDPs) lack a stable three-dimensional structure under physiological conditions but play crucial roles in many biological processes.
CanZhuang Sun, YongE Feng, GuoLiang Fan
doaj   +1 more source