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Functions of Intrinsically Disordered Regions [PDF]

Biology
Intrinsically disordered regions (IDRs), defined as protein segments lacking stable tertiary structures, are ubiquitously present in the human proteome and enriched with disease-associated mutations. IDRs harbor molecular recognition features (MoRFs) and
Linhu Xiao, Kun Xia
doaj   +4 more sources

Decoding intrinsically disordered regions in biomolecular condensates [PDF]

Fundamental Research
Biomolecular condensates comprise a diverse array of molecular entities, with intrinsically disordered regions (IDRs) receiving mounting attention due to their pivotal roles. In recent years, significant progress has been made in understanding the linear
Minglei Shi, Zhaoxu Wu, Yi Zhang, Tingting Li   +3 more
doaj   +4 more sources

Dynamic networks of intrinsically disordered regions in nuclear proteins [PDF]

Biophysics and Physicobiology
Chromatin in the eukaryotic nucleus is organized into transcriptionally active euchromatin and transcriptionally silent heterochromatin. Its fundamental unit, the nucleosome, consists of two copies each of histones H2A, H2B, H3, and H4 wrapped by ~145 ...
Yoshifumi Nishimura
doaj   +4 more sources

Design principles of transcription factors with intrinsically disordered regions [PDF]

eLife
Transcription factors (TFs) are proteins crucial for regulating gene expression. Effective regulation requires the TFs to rapidly bind to their correct target, enabling the cell to respond efficiently to stimuli such as nutrient availability or the ...
Wencheng Ji, Ori Hachmo, Naama Barkai, Ariel Amir   +3 more
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Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell.

PLoS ONE, 2019
Many studies about classification and the functional annotation of intrinsically disordered proteins (IDPs) are based on either the occurrence of long disordered regions or the fraction of disordered residues in the sequence.
Antonio Deiana, Sergio Forcelloni, Alessandro Porrello, Andrea Giansanti   +3 more
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Intrinsically disordered regions facilitate target search to drive promoter selectivity by a yeast transcription factor [PDF]

Nature Communications
Transcription factors regulate gene expression by binding specific DNA motifs, yet only a fraction of putative sites is occupied in vivo. Intrinsically disordered regions have emerged as key contributors to promoter selectivity, but the underlying ...
Nir Strugo, Carmit Burstein, Sk Saddam Hossain, Noam Nago, Hadeel Khamis, Ariel Kaplan   +5 more
doaj   +2 more sources

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 [PDF]

Nature Communications
The cell-type-specific function of transcription factors (TFs) is crucial for determining cellular identity. However, it is unclear how a single TF can function specifically in different cell types. Here, we define the molecular features that enable OCT4
Burak Ozkan, Mitzy Rios de Anda, Elisa Hall-Ponsele, Maria Rosa Portero Migueles, Amani Alshaikh, Marta Hanzevacki, Moriyah Naama, Katharine Furlong, Gareth A. Roberts, Meryam Beniazza, My Linh Huynh, Michael R. O’Dwyer, Sonia Yiakoumi, Christos Spanos, Hazar Yassen, Keisuke Kaji, Hitoshi Niwa, Yosef Buganim, Sally Lowell, Abdenour Soufi   +19 more
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Molecular grammars of predicted intrinsically disordered regions that span the human proteome. [PDF]

Cell
Ruff KM, King MR, Ying AW, Liu V, Pant A, Lieberman WE, Shinn MK, Su X, Kadoch C, Pappu RV.   +9 more
europepmc   +2 more sources

The Origin of Discrepancies between Predictions and Annotations in Intrinsically Disordered Proteins

Biomolecules, 2023
Disorder prediction methods that can discriminate between ordered and disordered regions have contributed fundamentally to our understanding of the properties and prevalence of intrinsically disordered proteins (IDPs) in proteomes as well as their ...
Mátyás Pajkos, Gábor Erdős, Zsuzsanna Dosztányi   +2 more
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Prediction of folding patterns for intrinsic disordered protein

Scientific Reports, 2023
The conformation flexibility of natural protein causes both complexity and difficulty to understand the relationship between structure and function. The prediction of intrinsically disordered protein primarily is focusing on to disclose the regions with ...
Jiaan Yang, Wen-xiang Cheng, Gang Wu, Sitong Sheng, Peng Zhang   +4 more
doaj   +1 more source