Results 21 to 30 of about 4,746 (287)
Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. [PDF]
BMC Biochemistry, 2014 BACKGROUND: Neuronal differentiation is largely under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles during development of the embryonic nervous system.
Gary S McDowell +4 more
core +7 more sources
PLoS ONE, 2014 With the exponential increase in the number of sequenced organisms, automated annotation of proteins is becoming increasingly important. Intrinsically disordered regions are known to play a significant role in protein function.
Alok Sharma +6 more
doaj +2 more sources
OPAL: prediction of MoRF regions in intrinsically disordered protein sequences [PDF]
, 2018 Motivation: Intrinsically disordered proteins lack stable 3-dimensional structure and play a crucial role in performing various biological functions.
Patil, Ashwini +9 more
core +2 more sources
Introduction to intrinsically disordered proteins and regions
, 2019 Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are fascinating dynamic conformational ensembles that are observed under physiological conditions.
Lukasz Kurgan +7 more
core +3 more sources
Design principles of transcription factors with intrinsically disordered regions
eLifeTranscription factors (TFs) are proteins crucial for regulating gene expression. Effective regulation requires the TFs to rapidly bind to their correct target, enabling the cell to respond efficiently to stimuli such as nutrient availability or the ...
Wencheng Ji +3 more
doaj +5 more sources
Intrinsically disordered regions in the rodent hepevirus proteome [PDF]
Bioinformation, 2022 Hepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or intrinsically disordered proteins (IDPs) are regions or proteins that are characterized by lack of definite structure.
Shafat, Zoya +4 more
openaire +2 more sources
Intrinsically disordered regions in autophagy proteins [PDF]
Proteins: Structure, Function, and Bioinformatics, 2013 ABSTRACTAutophagy is an essential eukaryotic pathway required for cellular homeostasis. Numerous key autophagy effectors and regulators have been identified, but the mechanism by which they carry out their function in autophagy is not fully understood.
Yang, Mei +5 more
openaire +2 more sources
Multifunctional Intrinsically Disordered Regions in Transcription Factors
Chemistry – A European Journal, 2023 AbstractEukaryotic transcription factors (TFs) are the final integrators of a complex molecular feedback mechanism that interfaces with the genome, consolidating information for transcriptional regulation. TFs consist of both structured DNA‐binding domains and long intrinsically disordered regions (IDRs) embedded with motifs linked to transcriptional ...
Matti Már +2 more
openaire +2 more sources
The repeat region of cortactin is intrinsically disordered in solution [PDF]
Scientific Reports, 2017 AbstractThe multi-domain protein, cortactin, contains a 37-residue repeating motif that binds to actin filaments. This cortactin repeat region comprises 6½ similar copies of the motif and binds actin filaments. To better understand this region of cortactin, and its fold, we conducted extensive biophysical analysis.
Xiaofeng Li +7 more
openaire +2 more sources
Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a [PDF]
Intrinsically Disordered Proteins, 2015 Forkhead box Class O is one of 19 subfamilies of the Forkhead box family, comprising 4 human transcription factors: FOXO1, FOXO3a, FOXO4, and FOXO6, which are involved in many crucial cellular processes. FOXO3a is a tumor suppressor involved in multiple physiological and pathological processes, and plays essential roles in metabolism, cell cycle arrest,
Feng, Wang +2 more
openaire +2 more sources