Results 41 to 50 of about 4,746 (287)

Structural characterization of intrinsically disordered proteins by NMR spectroscopy.

, 2013
Recent advances in NMR methodology and techniques allow the structural investigation of biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well-suited for the study of intrinsically disordered proteins (IDPs) and ...
Contreras-Martos, Sara, Peter Tompa, Cedeno, Cesyen, Simone Kosol, Kosol, Simone, Tompa, Péter, Sara Contreras-Martos, Cesyen Cedeño   +7 more
core   +1 more source

Folding factors and partners for the intrinsically disordered protein Micro-Exon Gene 14 (MEG-14)

, 2013
The micro-exon genes (MEG) of Schistosoma mansoni, a parasite responsible for the second most widely spread tropical disease, code for small secreted proteins with sequences unique to the Schistosoma genera.
Orcia, Debora, Araujo, A.P.U., Wallace, Bonnie A., Araújo, Ana Paula Ulian de, De Marco, Ricardo, Araujo, Ana Paula U., Debora Orcia, Wallace, B. A., Lopes, Jose Luiz S., DeMarco, Ricardo, Lopes, J.L.S., Ricardo DeMarco, Ana Paula U. Araujo, Orcia, D., B.A. Wallace, Wallace, B.A., Jose Luiz S. Lopes, DeMarco, R.   +17 more
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Differences in the number of intrinsically disordered regions between yeast duplicated proteins, and their relationship with functional divergence. [PDF]

PLoS ONE, 2011
BACKGROUND: Intrinsically disordered regions are enriched in short interaction motifs that play a critical role in many protein-protein interactions. Since new short interaction motifs may easily evolve, they have the potential to rapidly change protein ...
Floriane Montanari, Denis C Shields, Nora Khaldi   +2 more
doaj   +1 more source

The N-terminal intrinsically disordered domain of mgm101p is localized to the mitochondrial nucleoid.

, 2013
The mitochondrial genome maintenance gene, MGM101, is essential for yeasts that depend on mitochondrial DNA replication. Previously, in Saccharomyces cerevisiae, it has been found that the carboxy-terminal two-thirds of Mgm101p has a functional core ...
George Desmond Clark-Walker (281878), George Desmond Clark-Walker, Dosztányi Zsuzsanna, Zsuzsanna Dosztányi (57464), Clark-Walker, George Desmond, Zsuzsanna Dosztányi, Clark-Walker George Desmond, David C. Hayward (198611), David C. Hayward, Hayward David C., Hayward, David C., Dosztányi, Zsuzsanna, David C Hayward   +12 more
core   +1 more source

Dss1 Is a 26S Proteasome Ubiquitin Receptor [PDF]

, 2014
The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome.
Hardwick, Kevin G., Hay, Ronald T., Larsen, Ida B., Kragelund, Birthe B., Tatham, Michael H, Rösner, Heike I, Kragelund, Birthe Brandt, Hay, Ronald T, Kragelund, Birthe B, Kriegenburg, Franziska, Tatham, Michael H., Rösner, Heike Ilona, Paraskevopoulos, Konstantinos, Brandstrup, Rikke, Larsen, Ida B, Medina, Bethan; id_orcid, Hartmann-Petersen, Rasmus, Gordon, Colin, Rösner, Heike I., Hardwick, Kevin G, Medina, Bethan   +20 more
core   +1 more source

Fairy tails: Flexibility and function of intrinsically disordered extensions in the photosynthetic world

Frontiers in Molecular Biosciences, 2015
Intrinsically Disordered Proteins (IDPs), or protein fragments also called Intrinsically Disordered Regions (IDRs), display high flexibility as the result of their amino acid composition. They can adopt multiple roles.
Gabriel eThieulin-Pardo, Luisana eAvilan, Mila eKojadinovic, Brigitte eGontero   +3 more
doaj   +1 more source

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL [PDF]

Nature Chemical Biology, 2018
Intrinsically disordered regions (IDRs) of proteins often regulate function upon post-translational modification (PTM) through interactions with folded domains. An IDR linking two α-helices (α1-α2) of the antiapoptotic protein Bcl-xL experiences several PTMs that reduce antiapoptotic activity.
Ariele Viacava Follis, Fabien Llambi, Halime Kalkavan, Yong Yao, Aaron H. Phillips, Cheon-Gil Park, Francesca M. Marassi, Douglas R. Green, Richard W. Kriwacki   +8 more
openaire   +2 more sources

Sequence-dependent correlated segments in the intrinsically disordered region of ChiZ [PDF]

Biomolecules, 2020
Abstract Intrinsically disordered proteins (IDPs) account for a significant fraction of any proteome and are central to numerous cellular functions. Yet how sequences of IDPs code for their conformational dynamics is poorly understood.
Hicks, Alan, Escobar, Cristian A., Cross, Timothy A., Zhou, Huan-Xiang   +3 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

DisProt in 2024: improving function annotation of intrinsically disordered proteins [PDF]

, 2023
International audienceDisProt (URL: https://disprot.org) is the gold standard database for intrinsically disordered proteins and regions, providing valuable information about their functions. The latest version of DisProt brings significant advancements,
Longhi, Sonia, Fatemeh Kordevani, Leonardi, Emanuela, Vasilis J Promponas, Promponas, Vasilis, Pintado-Grima, Carlos, Pajkos, Matyas, Sonia Longhi, Ventura, Salvador, Silvio C E Tosatto, Laszlo Dobson, Kulik, Mariane Goncalves, Mercier, Philippe Le, Erzsébet Fichó, Lazar, Tamas, Dosztányi, Zsuzsanna, Federica Quaglia, Galo E Balatti, Dobson, Laszlo, Carlos Pintado-Grima, Bouharoua, Adel, Zsófia Kálmán, Alessio Del Conte, Chasapi, Anastasia, Tamas Lazar, Juliet F Nilsson, Aspromonte, Maria Cristina, Monzon, Alexander Miguel, Maria Cristina Aspromonte, Carlo Ferrari, Nilsson, Juliet, Ku, Luiggi, Gustavo Parisi, Gabor Erdos, Vasileios Sagris, Conte, Alessio Del, Kordevani, Fatemeh, Tompa, Peter, Veronika Ács, Maria Victoria Nugnes, Bergier, Julian, Philippe Le Mercier, Peter Tompa, Quaglia, Federica, Hamidreza Ghafouri, Parisi, Gustavo, Fichó, Erzsébet, Erdos, Gabor, Pedro José Barbosa Pereira, Piovesan, Damiano, Balatti, Galo, Pancsa, Rita, Kálmán, Zsófia, Jaime Santos, Alexander Miguel Monzon, Edoardo Salladini, Salladini, Edoardo, Pereira, Pedro José Barbosa, Sagris, Vasileios, Santos, Jaime, Zsuzsanna Dosztányi, Emanuela Leonardi, Andrade-Navarro, Miguel, Clementel, Damiano, Nugnes, Maria Victoria, Buitrón, Martín González, Damiano Clementel, KAMEL EDDINE ADEL BOUHRAOUA, Mariane Goncalves Kulik, Miguel A Andrade-Navarro, Matyas Pajkos, Ács, Veronika, Anastasia Chasapi, Ferrari, Carlo, Julian Bergier, Rita Pancsa, Martín González Buitrón, Salvador Ventura, Ghafouri, Hamidreza, Luiggi G Tenorio Ku, Tosatto, Silvio, C E, Damiano Piovesan   +81 more
core   +1 more source