D2P2: database of disordered protein predictions [PDF]
, 2013 We present the Database of Disordered Protein Prediction (D2P2), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein ...
Oates, Matt E. +3 more
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PLoS ONE, 2014 With the exponential increase in the number of sequenced organisms, automated annotation of proteins is becoming increasingly important. Intrinsically disordered regions are known to play a significant role in protein function.
Alok Sharma +6 more
doaj +1 more source
Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions
Biomolecules, 2020 Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival, or apoptosis.
Mátyás Pajkos +2 more
doaj +1 more source
Intrinsically disordered regions (IDRs) that are intolerant to mutations and their categories.
, 2022 Intrinsically disordered regions (IDRs) that are intolerant to mutations and their categories.
Arthur J. Campbell (2167885) +6 more
core +1 more source
, 2023 Intrinsically disordered regions of transcription factor encode multiple functions using interwoven sequence ...
Vova Mindel
core +1 more source
Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data [PDF]
, 2009 Background: Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation.
Jones, DT +7 more
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Many-to-one binding by intrinsically disordered protein regions
Biocomputing 2020, 2019 Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions. DBR-protein complexes were collected from the Protein Data Bank for which two or more DBRs having different amino acid sequences bind to the same (100% sequence ...
Alterovitz, Wei-Lun +9 more
openaire +4 more sources
Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions [PDF]
Science Advances, 2019 Kap121 interacts with an intrinsically disordered region of Nup53 to allosterically modulate Nup53 binding to partner nucleoporins.
Bartlomiej Jan Blus +5 more
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Differences in the number of intrinsically disordered regions between yeast duplicated proteins, and their relationship with functional divergence. [PDF]
PLoS ONE, 2011 BACKGROUND: Intrinsically disordered regions are enriched in short interaction motifs that play a critical role in many protein-protein interactions. Since new short interaction motifs may easily evolve, they have the potential to rapidly change protein ...
Floriane Montanari +2 more
doaj +1 more source
Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome [PDF]
, 2013 A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame.
Kalmár, Lajos +2 more
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