Results 1 to 10 of about 11,990,533 (304)

ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells

Scientific Reports, 2022
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that regulates endosomal trafficking in eukaryotic cells. Recent studies have shown that VPS35 promotes tumor cell proliferation and affects the nuclear accumulation of its ...
Xian Hong, Tao Wang, Juan Du, Yu Hong, Cai-Ping Yang, Wei Xiao, Yang Li, Ming Wang, He Sun, Zhi-Hui Deng   +9 more
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Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells

BMC Cancer, 2021
Background Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extracellular compartment in multiple ...
Xian Hong, Zhi-Xuan Li, Jie Hou, Hui-Yu Zhang, Chun-Yan Zhang, Jian Zhang, He Sun, Li-Hong Pang, Tao Wang, Zhi-Hui Deng   +9 more
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WASH interacts with Ku to regulate DNA double-stranded break repair

iScience, 2022
Summary: The Wiskott-Aldrich syndrome protein and SCAR homolog (WASH), an actin nucleation-promoting factor, is present in the nucleus where it regulates gene transcription and maintains nuclear organization.
Tao Wang, Xiao-Hui Du, Yu Hong, Xian Hong, Li Fan, Jian-Wen Zhou, He Sun, Jie Ge, Daniel D. Billadeau, Zhi-Hui Deng   +9 more
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Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

Cell Communication and Signaling, 2020
Background Cancer stem cells (CSCs), the major driver of tumorigenesis, is a sub-population of tumor cells responsible for poor clinical outcomes. However, molecular mechanism to identify targets for controlling CSCs is poorly understood.
Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Dong-Kyu Kwak, Jaebeom Cho, Dong Woo Kang, Ho-Young Lee, Kang-Yell Choi   +7 more
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3-Ketoacyl-ACP synthase III FabH1 is essential for branched-chain DSF family signals in Xanthomonas oryzae pv. oryzae

Phytopathology Research, 2023
The 3-ketoacyl-ACP synthase III (FabH), a key enzyme for bacteria growth, catalyses the last step of the initiation of bacterial fatty acid synthesis. Rice bacterial blight is caused by the pathogen Xanthomonas oryzae pv.
Mingfeng Yan, Yonghong Yu, Lizhen Luo, Mei Huang, Yuanyin Zhang, Jingtong Su, Wenbin Zhang, Jincheng Ma, Zhe Hu, Haihong Wang   +9 more
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Environmental determinants and demographic influences on global urban microbiomes, antimicrobial resistance and pathogenicity

npj Biofilms and Microbiomes, 2023
Urban microbiome plays crucial roles in human health and are related to various diseases. The MetaSUB Consortium has conducted the most comprehensive global survey of urban microbiomes to date, profiling microbial taxa/functional genes across 60 cities ...
Yang Chen, Xi Fu, Zheyuan Ou, Jiang Li, Simiao Lin, Yaoxuan Wu, Xuwei Wang, Yiqun Deng, Yu Sun   +8 more
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WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

Cell Communication and Signaling, 2019
Background Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC).
Eun Ji Ro, Yong-Hee Cho, Woo-Jeong Jeong, Jong-Chan Park, Do Sik Min, Kang-Yell Choi   +5 more
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Co-expressing GroEL–GroES, Ssa1–Sis1 and Bip–PDI chaperones for enhanced intracellular production and partial-wall breaking improved stability of porcine growth hormone

Microbial Cell Factories, 2020
Porcine growth hormone (pGH) is a class of peptide hormones secreted from the pituitary gland, which can significantly improve growth and feed utilization of pigs. However, it is unstable and volatile in vitro.
Jinbo Deng, Jiaoqing Li, Miaopeng Ma, Peijing Zhao, Feiping Ming, Zhipeng Lu, Juqing Shi, Qin Fan, Qianyi Liang, Junhao Jia, Jiayi Li, Shuxia Zhang, Linghua Zhang   +12 more
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The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2

Metabolites, 2023
Human AKR 7A2 broadly participates in the metabolism of a number of exogenous and endogenous compounds. Azoles are a class of clinically widely used antifungal drugs, which are usually metabolized by CYP 3A4, CYP2C19, and CYP1A1, etc. in vivo.
Wanying Wu, Tianqing Jiang, Haihui Lin, Chao Chen, Lingling Wang, Jikai Wen, Jun Wu, Yiqun Deng   +7 more
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A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Experimental and Molecular Medicine, 2018
Colorectal cancer: Potential treatment for drug-resistant cases A recently identified small molecule shows promise for tackling resistance to a leading colorectal cancer drug.
Sang-Kyu Lee, Yong-Hee Cho, Pu-Hyeon Cha, Jeong-Soo Yoon, Eun Ji Ro, Woo-Jeong Jeong, Jieun Park, Hyuntae Kim, Tae Il Kim, Do Sik Min, Gyoonhee Han, Kang-Yell Choi   +11 more
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