Results 21 to 30 of about 11,494,730 (307)

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Nature Communications, 2019
Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor ...
Woo-Jeong Jeong, Jong-Chan Park, Woo-Shin Kim, Eun Ji Ro, Soung Hoo Jeon, Sang-Kyu Lee, Young Nyun Park, Do Sik Min, Kang-Yell Choi   +8 more
doaj   +1 more source

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

Experimental and Molecular Medicine, 2018
Colorectal cancer: Finding new small molecule drug candidates Mutations in KRAS, a gene regulating cell proliferation, occur in 40–50% of colorectal cancer (CRC) patients.
Wookjin Shin, Sang-Kyu Lee, Jeong-Ha Hwang, Jong-Chan Park, Yong-Hee Cho, Eun Ji Ro, Yeonhwa Song, Haeng Ran Seo, Kang-Yell Choi   +8 more
doaj   +1 more source

Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway

Experimental and Molecular Medicine, 2019
Small molecular approach to increase height growth A compound that stimulates longitudinal bone growth could lead to safer treatments for children with short stature.
Sehee Choi, Pu-Hyeon Cha, Hyun-Yi Kim, Kang-Yell Choi   +3 more
doaj   +1 more source

New Insights into the Virulence Traits and Antibiotic Resistance of Enterococci Isolated from Diverse Probiotic Products

Microorganisms, 2021
The GRAS (generally recognized as safe) status of Enterococcus has not yet been authenticated, but enterococci, as probiotics, have been increasingly applied in human healthcare and animal husbandry, for instance as a dietary supplement, feed additive ...
Fengru Deng, Yunsheng Chen, Xiaoyu Zhou, Huiying Xiao, Tianyu Sun, Yiqun Deng, Jikai Wen   +6 more
doaj   +1 more source

Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling

Oncogenesis, 2022
HBP1 is a sequence-specific transcription factor which generally considered as a crucial growth inhibitor. Posttranslational modification of HBP1 is vital for its function.
Jiyin Wang, Ruixiang Yang, Yuning Cheng, Yue Zhou, Tongjia Zhang, Shujie Wang, Hui Li, Wei Jiang, Xiaowei Zhang   +8 more
doaj   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Bayesian Markov Random Rield Analysis for Protein Function Prediction Based on Network Data [PDF]

, 2010
Inference of protein functions is one of the most important aims of modern biology. To fully exploit the large volumes of genomic data typically produced in modern-day genomic experiments, automated computational methods for protein function prediction ...
ter Braak, C.J.F., Yiannis A I Kourmpetis, Cajo J F ter Braak, Kourmpetis, Y.I.A., Roeland C H J van Ham, Ham, R.C.H.J., van, Aalt D J van Dijk, van Dijk, A.D.J., Bink, M.C.A.M., van Dijk Aalt D. J., Kourmpetis Yiannis A. I., van Ham Roeland C. H. J., Dijk, A.D.J., van, Bink Marco C. A. M., Braak, C.J.F., ter, Marco C A M Bink, van Ham, R.C.H.J., ter Braak Cajo J. F.   +17 more
core   +2 more sources

HetI-Like Phosphopantetheinyl Transferase Posttranslationally Modifies Acyl Carrier Proteins in Xanthomonas spp.

Molecular Plant-Microbe Interactions, 2022
In Xanthomonas spp., the biosynthesis of the yellow pigment xanthomonadin and fatty acids originates in the type II polyketide synthase (PKS II) and fatty acid synthase (FAS) pathways, respectively. The acyl carrier protein (ACP) is the central component
Yi-Cai Chen, Zhe Hu, Wen-Bin Zhang, Yu Yin, Can-Yao Zhong, Wan-Ying Mo, Yong-Hong Yu, Jin-Cheng Ma, Hai-Hong Wang   +8 more
doaj   +1 more source

Alteration of protein function by a silent polymorphism linked to tRNA abundance [PDF]

, 2017
Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids.
Sebastian Kirchner, Rauscher, Robert, Ostedgaard, Lynda S., Cai, Zhiwei, Ineke Braakman, Bertrand Kleizen, Cellular Protein Chemistry, Kleizen, Bertrand, Lynda S. Ostedgaard, Zoya Ignatova, Sub Cellular Protein Chemistry, Czech, Andreas, Ignatova, Zoya, Robert Rauscher, Zhiwei Cai, Braakman, Ineke, Anding, Melanie, Sheppard, David N., Lynda S Ostedgaard, Nicolai Kastelic, David N Sheppard, David N. Sheppard, Melanie Anding, Andreas Czech, Kirchner, Sebastian, Sheppard, David, Kastelic, Nicolai, Ostegaard, Lynda   +27 more
core   +2 more sources

Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]

, 2012
Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core   +1 more source