Results 21 to 30 of about 521,366 (318)

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

Experimental and Molecular Medicine, 2018
Colorectal cancer: Finding new small molecule drug candidates Mutations in KRAS, a gene regulating cell proliferation, occur in 40–50% of colorectal cancer (CRC) patients.
Wookjin Shin, Sang-Kyu Lee, Jeong-Ha Hwang, Jong-Chan Park, Yong-Hee Cho, Eun Ji Ro, Yeonhwa Song, Haeng Ran Seo, Kang-Yell Choi   +8 more
doaj   +1 more source

New Insights into the Virulence Traits and Antibiotic Resistance of Enterococci Isolated from Diverse Probiotic Products

Microorganisms, 2021
The GRAS (generally recognized as safe) status of Enterococcus has not yet been authenticated, but enterococci, as probiotics, have been increasingly applied in human healthcare and animal husbandry, for instance as a dietary supplement, feed additive ...
Fengru Deng, Yunsheng Chen, Xiaoyu Zhou, Huiying Xiao, Tianyu Sun, Yiqun Deng, Jikai Wen   +6 more
doaj   +1 more source

Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway

Experimental and Molecular Medicine, 2019
Small molecular approach to increase height growth A compound that stimulates longitudinal bone growth could lead to safer treatments for children with short stature.
Sehee Choi, Pu-Hyeon Cha, Hyun-Yi Kim, Kang-Yell Choi   +3 more
doaj   +1 more source

FLORA: a novel method to predict protein function from structure in diverse superfamilies [PDF]

, 2009
Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation.
Dallman Timothy J., Nussinov, R., Oliver C. Redfern, Christine A. Orengo, Sillitoe, I., Dessailly Benoît H., Orengo, C.A., Benoît H Dessailly, Redfern, OC, Timothy J. Dallman, Oliver C Redfern, Benoît H. Dessailly, Dallman, TJ, Dessailly, B.H., Orengo Christine A., Ian Sillitoe, Timothy J Dallman, Sillitoe, I, Redfern Oliver C., Christine A Orengo, Dallman, T.J., Sillitoe Ian, Dessailly, BH, Redfern, O.C., Orengo, CA   +24 more
core   +1 more source

Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling

Oncogenesis, 2022
HBP1 is a sequence-specific transcription factor which generally considered as a crucial growth inhibitor. Posttranslational modification of HBP1 is vital for its function.
Jiyin Wang, Ruixiang Yang, Yuning Cheng, Yue Zhou, Tongjia Zhang, Shujie Wang, Hui Li, Wei Jiang, Xiaowei Zhang   +8 more
doaj   +1 more source

Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]

, 2012
Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core   +1 more source

HetI-Like Phosphopantetheinyl Transferase Posttranslationally Modifies Acyl Carrier Proteins in Xanthomonas spp.

Molecular Plant-Microbe Interactions, 2022
In Xanthomonas spp., the biosynthesis of the yellow pigment xanthomonadin and fatty acids originates in the type II polyketide synthase (PKS II) and fatty acid synthase (FAS) pathways, respectively. The acyl carrier protein (ACP) is the central component
Yi-Cai Chen, Zhe Hu, Wen-Bin Zhang, Yu Yin, Can-Yao Zhong, Wan-Ying Mo, Yong-Hong Yu, Jin-Cheng Ma, Hai-Hong Wang   +8 more
doaj   +1 more source

An empirical evaluation of the effectiveness of different types of predictor attributes in protein function prediction. [PDF]

, 2009
Many classification schemes for defining protein functions, such as Gene Ontology (GO), are organised in a hierarchical structure. Nodes near the root of the hierarchy represent general functions while nodes near the leaves of the hierarchy represent ...
Segond, Marc, Otero, Fernando E.B., Fernando Otero, Robilliard, Denis, Colin G. Johnson, Denis Robilliard, Johnson, Colin G., Fonlupt, Cyril, Alex A. Freitas, Cyril Fonlupt, Freitas, Alex A., Marc Segond   +11 more
core   +1 more source

Non-Contiguous Protein Recombination [PDF]

, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source

Computational aspects of protein functionality [PDF]

Comparative and Functional Genomics, 2004
AbstractThe purpose of this short article is to examine certain aspects of protein functionality with relation to some key organizing ideas. This is important from a computational viewpoint in order to take account of modelling both biological systems and knowledge of these systems.
Paton, R. C., Toh, C.-H.
openaire   +2 more sources