Results 41 to 50 of about 521,366 (318)

Characterization of 3-Oxacyl-Acyl Carrier Protein Reductase Homolog Genes in Pseudomonas aeruginosa PAO1

Frontiers in Microbiology, 2019
Bacterial 3-oxoacyl-ACP reductase (OAR) catalyzes the 3-oxoacyl-ACP reduction step in the fatty acid synthesis pathway. At least 12 genes in the Pseudomonas aeruginosa genome are annotated as OAR-encoding genes.
Qiao-Qiao Guo, Wen-Bin Zhang, Chao Zhang, Yu-Lu Song, Yu-Ling Liao, Jin-Cheng Ma, Yong-Hong Yu, Hai-Hong Wang   +7 more
doaj   +1 more source

HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression

Journal of Experimental & Clinical Cancer Research, 2021
Background Hepatoma is a common malignancy of the liver. The abnormal high expression of alpha-fetoprotein (AFP) is intimately associated with hepatoma progress, but the mechanism of transcriptional regulation and singularly activation of AFP gene in ...
Zhengyi Cao, Yuning Cheng, Jiyin Wang, Yujuan Liu, Ruixiang Yang, Wei Jiang, Hui Li, Xiaowei Zhang   +7 more
doaj   +1 more source

The FabA-FabB Pathway Is Not Essential for Unsaturated Fatty Acid Synthesis but Modulates Diffusible Signal Factor Synthesis in Xanthomonas campestris pv. campestris

Molecular Plant-Microbe Interactions, 2023
Most bacteria use type II fatty acid synthesis (FAS) systems for synthesizing fatty acids, of which the conserved FabA-FabB pathway is considered to be crucial for unsaturated fatty acid (UFA) synthesis in gram-negative bacteria.
Yong-Hong Yu, Cheng Chen, Jian-Rong Ma, Yuan-Yin Zhang, Ming-Feng Yan, Wen-Bin Zhang, Zhe Hu, Hai-Hong Wang, Jin-Cheng Ma   +8 more
doaj   +1 more source

Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B1

Toxins, 2016
Due to unavoidable contaminations in feedstuff, pigs are easily exposed to aflatoxin B1 (AFB1) and suffer from poisoning, thus the poisoned products potentially affect human health.
Jun Wu, Ruohong Chen, Caihui Zhang, Kangbai Li, Weiying Xu, Lijuan Wang, Qingmei Chen, Peiqiang Mu, Jun Jiang, Jikai Wen, Yiqun Deng   +10 more
doaj   +1 more source

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela, Tosatto, Silvio C. E., Giorgia Busolin, Simonetta Andreazza, Busolin, Giorgia, Tosatto, Silvio C E, Emanuela Leonardi, Carlo Nobile, Silvio C E Tosatto, TOSATTO, SILVIO, Busolin Giorgia, Silvio C. E. Tosatto, Tosatto Silvio C. E., Vanin, Stefano, Vanin Stefano, NOBILE C, Langowski, Jörg, Stefano Vanin, Andreazza Simonetta, Andreazza, Simonetta, Nobile, Carlo, ANDREAZZA A, Leonardi Emanuela, Nobile Carlo   +23 more
core   +1 more source

Identification and Enzyme Activity Comparison of Cellulase-producing Bacillus

Guangdong nongye kexue, 2022
【Objective】The research was carried out to screen out celllulase-producing strains from 14 strains of bacteria in order to provide a material basis for the development of new feed additives.【Method】The cellulase-producing strains were screened out from ...
Xuebin JIANG, Xuehong CHENG, Miaopeng MA, Zhongqing DENG, Jiahui LI   +4 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Bayesian Markov Random Rield Analysis for Protein Function Prediction Based on Network Data

, 2010
Inference of protein functions is one of the most important aims of modern biology. To fully exploit the large volumes of genomic data typically produced in modern-day genomic experiments, automated computational methods for protein function prediction ...
ter Braak, C.J.F., Yiannis A I Kourmpetis, Cajo J F ter Braak, Kourmpetis, Y.I.A., Roeland C H J van Ham, Ham, R.C.H.J., van, Aalt D J van Dijk, van Dijk, A.D.J., Bink, M.C.A.M., van Dijk Aalt D. J., Kourmpetis Yiannis A. I., van Ham Roeland C. H. J., Dijk, A.D.J., van, Bink Marco C. A. M., Braak, C.J.F., ter, Marco C A M Bink, van Ham, R.C.H.J., ter Braak Cajo J. F.   +17 more
core   +1 more source

Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]

, 2009
To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source