Results 41 to 50 of about 11,990,533 (304)

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Estes, M. K., Guix Arnau, Susana, Katayama, K., Crawford, Sue E., Sharp, T. M.   +4 more
core   +3 more sources

Computational Analyses of Protein-Ligand Interactions [PDF]

, 2010
Protein-ligand interactions have a central role in all processes in living systems. A comprehensive understanding of protein interactions with small molecules is of great interest as it provides opportunities for understanding protein function and ...
Haider, Kamran
core   +4 more sources

Characterization of 3-Oxacyl-Acyl Carrier Protein Reductase Homolog Genes in Pseudomonas aeruginosa PAO1

Frontiers in Microbiology, 2019
Bacterial 3-oxoacyl-ACP reductase (OAR) catalyzes the 3-oxoacyl-ACP reduction step in the fatty acid synthesis pathway. At least 12 genes in the Pseudomonas aeruginosa genome are annotated as OAR-encoding genes.
Qiao-Qiao Guo, Wen-Bin Zhang, Chao Zhang, Yu-Lu Song, Yu-Ling Liao, Jin-Cheng Ma, Yong-Hong Yu, Hai-Hong Wang   +7 more
doaj   +1 more source

Virulence Functions of Autotransporter Proteins [PDF]

Infection and Immunity, 2001
Bacterial pathogens must execute a prodigious array of complex functions in order to survive, multiply, and disseminate within mammalian hosts. Virulence determinants are usually proteinaceous in nature and are often either secreted to the bacterial cell surface or released into the ...
Henderson, Ian R., Nataro, James P.
openaire   +5 more sources

Inferring function using patterns of native disorder in proteins [PDF]

, 2007
Natively unstructured regions are a common feature of eukaryotic proteomes. Between 30% and 60% of proteins are predicted to contain long stretches of disordered residues, and not only have many of these regions been confirmed experimentally, but they ...
Swindells, MB, Jones, DT, Mark B. Swindells, David T. Jones, Lobley, A, Lobley, A., Christine A. Orengo, David T Jones, Mark B Swindells, Swindells, M.B., Orengo, C.A., Christine A Orengo, Jones, D.T., Anna Lobley, Orengo, CA   +14 more
core   +2 more sources

Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B1

Toxins, 2016
Due to unavoidable contaminations in feedstuff, pigs are easily exposed to aflatoxin B1 (AFB1) and suffer from poisoning, thus the poisoned products potentially affect human health.
Jun Wu, Ruohong Chen, Caihui Zhang, Kangbai Li, Weiying Xu, Lijuan Wang, Qingmei Chen, Peiqiang Mu, Jun Jiang, Jikai Wen, Yiqun Deng   +10 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression

Journal of Experimental & Clinical Cancer Research, 2021
Background Hepatoma is a common malignancy of the liver. The abnormal high expression of alpha-fetoprotein (AFP) is intimately associated with hepatoma progress, but the mechanism of transcriptional regulation and singularly activation of AFP gene in ...
Zhengyi Cao, Yuning Cheng, Jiyin Wang, Yujuan Liu, Ruixiang Yang, Wei Jiang, Hui Li, Xiaowei Zhang   +7 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Predicting the Impact of Alternative Splicing on Plant MADS Domain Protein Function [PDF]

, 2012
Several genome-wide studies demonstrated that alternative splicing (AS) significantly increases the transcriptome complexity in plants. However, the impact of AS on the functional diversity of proteins is difficult to assess using genome-wide approaches.
Richard G. H. Immink, C. H. J. Van Ham, Edouard I. Severing, Aalt D. J. Van Dijk, Roeland C. H. J. van Ham (116982), Severing, E.I., Busscher-Lange Jacqueline, Roeland C H J van Ham, Aalt D J van Dijk, Richard G H Immink, van Dijk Aalt D. J., Severing Edouard I., Aalt D. J. van Dijk (18076), Morabito, G., van Ham Roeland C. H. J., Giuseppa Morabito, Edouard I Severing, Richard G. H. Immink (186449), Jacqueline Busscher-Lange (186442), Jacqueline Busscher-Lange, Busscher-Lange, J., Morabito Giuseppa, Ham, R.C.H.J., van, Immink, G.H., Edouard I. Severing (186432), Dijk, A.D.J., van, Immink Richard G. H., Giuseppa Morabito (186438)   +27 more
core   +3 more sources