Results 31 to 40 of about 11,990,533 (304)

Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]

, 2012
Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core   +1 more source

Author Correction: Hybridization is a recurrent evolutionary stimulus in wild yeast speciation

Nature Communications, 2019
The original version of the Supplementary Information associated with this Article contained errors in Supplementary Figures 2, 12, 20 and 22. The HTML has been updated to include a corrected version of the Supplementary Information; the original ...
Chris Eberlein, Mathieu Hénault, Anna Fijarczyk, Guillaume Charron, Matteo Bouvier, Linda M. Kohn, James B. Anderson, Christian R. Landry   +7 more
doaj   +1 more source

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma

BMC Cancer, 2021
Background Icaritin, an active ingredient of the Chinese herb Epimedium, plays an anti-tumor role in liver cancer by inhibiting the proliferation of hepatocellular cells and promoting their apoptosis.
Hui Li, Yujuan Liu, Wei Jiang, Junhui Xue, Yuning Cheng, Jiyin Wang, Ruixiang Yang, Xiaowei Zhang   +7 more
doaj   +1 more source

Functions of the Prion Protein

, 2017
Although initially disregarded compared to prion pathogenesis, the functions exerted by the cellular prion protein PrPC have gained much interest over the past two decades. Research aiming at unraveling PrPC functions started to intensify when it became appreciated that it would give clues as to how it is subverted in the context of prion infection and,
Hirsch, Théo, Martin-Lannerée, Séverine, Mouillet-Richard, Sophie   +2 more
openaire   +2 more sources

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela, Tosatto, Silvio C. E., Giorgia Busolin, Simonetta Andreazza, Busolin, Giorgia, Tosatto, Silvio C E, Emanuela Leonardi, Carlo Nobile, Silvio C E Tosatto, TOSATTO, SILVIO, Busolin Giorgia, Silvio C. E. Tosatto, Tosatto Silvio C. E., Vanin, Stefano, Vanin Stefano, NOBILE C, Langowski, Jörg, Stefano Vanin, Andreazza Simonetta, Andreazza, Simonetta, Nobile, Carlo, ANDREAZZA A, Leonardi Emanuela, Nobile Carlo, Tosatto Silvio C E   +24 more
core   +1 more source

Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function [PDF]

, 2018
Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions.

core   +2 more sources

GP73-mediated secretion of AFP and GP73 promotes proliferation and metastasis of hepatocellular carcinoma cells

Oncogenesis, 2021
Golgi protein 73 (GP73) and alpha fetoprotein (AFP) serve as biomarkers for the diagnosis of hepatocellular carcinoma (HCC), and their serum levels correlate with patients’ outcomes. However, the mechanisms underlying these correlations are unknown. Here
Yujuan Liu, Jiyin Wang, Ruixiang Yang, Yuning Cheng, Yue Zhou, Hui Li, Wei Jiang, Xiaowei Zhang   +7 more
doaj   +1 more source

Computational aspects of protein functionality [PDF]

Comparative and Functional Genomics, 2004
AbstractThe purpose of this short article is to examine certain aspects of protein functionality with relation to some key organizing ideas. This is important from a computational viewpoint in order to take account of modelling both biological systems and knowledge of these systems.
Paton, R. C., Toh, C.-H.
openaire   +2 more sources

Resistant Protein: Forms and Functions

Foods, 2022
Several global health risks are related to our dietary lifestyle. As a consequence of the overconsumption of ultra-processed and highly digestible protein (150–200% of the recommended value), excess dietary proteins reach the colon, are hydrolysed to peptides and amino acids by bacterial proteases and fermented to various potentially toxic end products.
Emanuele Zannini, Aylin W. Sahin, Elke K. Arendt   +2 more
openaire   +4 more sources

An assessment of feature relevance in predicting protein function from sequence [PDF]

, 2004
Improving the performance of protein function prediction is the ultimate goal for a bioinformatician working in functional genomics. The classical prediction approach is to employ pairwise sequence alignments. However this method often faces difficulties
Tan, AC, Al-Shahib, A, Tan, A.C., Gilbert, D, Gilbert, D.G., Aik Choon Tan, Chao He, Al-Shahib, Ali, Girolami, M, Mark Girolami, David Gilbert, Gilbert, M, ,, Girolami, M., He, C, Ali Al-shahib, He, C., Al-Shahib, A.   +17 more
core   +1 more source