Results 11 to 20 of about 521,366 (318)

An artificial immune system for clustering amino acids in the context of protein function classification [PDF]

, 2009
This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon, Clark, Edward, Flower, Darren R., Secker, Andrew D., Davies, Matthew N., Freitas, Alex A.   +5 more
core   +1 more source

Co-expressing GroEL–GroES, Ssa1–Sis1 and Bip–PDI chaperones for enhanced intracellular production and partial-wall breaking improved stability of porcine growth hormone

Microbial Cell Factories, 2020
Porcine growth hormone (pGH) is a class of peptide hormones secreted from the pituitary gland, which can significantly improve growth and feed utilization of pigs. However, it is unstable and volatile in vitro.
Jinbo Deng, Jiaoqing Li, Miaopeng Ma, Peijing Zhao, Feiping Ming, Zhipeng Lu, Juqing Shi, Qin Fan, Qianyi Liang, Junhao Jia, Jiayi Li, Shuxia Zhang, Linghua Zhang   +12 more
doaj   +1 more source

The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2

Metabolites, 2023
Human AKR 7A2 broadly participates in the metabolism of a number of exogenous and endogenous compounds. Azoles are a class of clinically widely used antifungal drugs, which are usually metabolized by CYP 3A4, CYP2C19, and CYP1A1, etc. in vivo.
Wanying Wu, Tianqing Jiang, Haihui Lin, Chao Chen, Lingling Wang, Jikai Wen, Jun Wu, Yiqun Deng   +7 more
doaj   +1 more source

Functional protein dynamics in a crystal

Biophysical Journal, 2023
Abstract Proteins are molecular machines and to understand how they work, we need to understand how they move. New pump-probe time-resolved X-ray diffraction methods open up ways to initiate and observe protein motions with atomistic detail in crystals on biologically relevant timescales.
Eugene Klyshko, Justin Sung-Ho Kim, Lauren McGough, Victoria Valeeva, Ethan Lee, Rama Ranganathan, Sarah Rauscher   +6 more
openaire   +5 more sources

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Experimental and Molecular Medicine, 2018
Colorectal cancer: Potential treatment for drug-resistant cases A recently identified small molecule shows promise for tackling resistance to a leading colorectal cancer drug.
Sang-Kyu Lee, Yong-Hee Cho, Pu-Hyeon Cha, Jeong-Soo Yoon, Eun Ji Ro, Woo-Jeong Jeong, Jieun Park, Hyuntae Kim, Tae Il Kim, Do Sik Min, Gyoonhee Han, Kang-Yell Choi   +11 more
doaj   +1 more source

Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit

Nature Communications, 2023
Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu, Philipp F. Popp, Mònica Santiveri, Aritz Roa-Eguiara, Yumeng Yan, Freddie J. O. Martin, Zheyi Liu, Navish Wadhwa, Yong Wang, Marc Erhardt, Nicholas M. I. Taylor   +10 more
doaj   +1 more source

Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol

Toxins, 2020
Deoxynivalenol (DON) is a highly abundant mycotoxin that exerts many adverse effects on humans and animals. Much effort has been made to control DON in the past, and bio-transformation has emerged as the most promising method.
Xiaojuan Gao, Peiqiang Mu, Xunhua Zhu, Xiaoxuan Chen, Shulin Tang, Yuting Wu, Xiang Miao, Xiaohan Wang, Jikai Wen, Yiqun Deng   +9 more
doaj   +1 more source

Functional Residues in Proteins [PDF]

Journal of Amino Acids, 2011
We are delighted to present a special issue on the subject of functional residues of proteins. Finding focused articles within the time frame of a special issue is always challenging, which is further compounded by authors' reluctance in making their contributions to new journals. We have been fortunate enough that some leading researchers in the field
Ahmad, Shandar, Wang, Jung-Ying, Ahmad, Zulfiqar, Ahmad, Faizan   +3 more
openaire   +2 more sources

Alteration of protein function by a silent polymorphism linked to tRNA abundance [PDF]

, 2017
Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids.
Sebastian Kirchner, Rauscher, Robert, Ostedgaard, Lynda S., Cai, Zhiwei, Ineke Braakman, Bertrand Kleizen, Cellular Protein Chemistry, Kleizen, Bertrand, Lynda S. Ostedgaard, Zoya Ignatova, Sub Cellular Protein Chemistry, Czech, Andreas, Ignatova, Zoya, Robert Rauscher, Zhiwei Cai, Braakman, Ineke, Anding, Melanie, Sheppard, David N., Lynda S Ostedgaard, Nicolai Kastelic, David N Sheppard, David N. Sheppard, Melanie Anding, Andreas Czech, Kirchner, Sebastian, Sheppard, David, Kastelic, Nicolai, Ostegaard, Lynda   +27 more
core   +1 more source

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Nature Communications, 2019
Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor ...
Woo-Jeong Jeong, Jong-Chan Park, Woo-Shin Kim, Eun Ji Ro, Soung Hoo Jeon, Sang-Kyu Lee, Young Nyun Park, Do Sik Min, Kang-Yell Choi   +8 more
doaj   +1 more source