Results 11 to 20 of about 11,494,730 (307)
Prediction of Protein Function Using Statistically Significant Sub-Structure Discovery [PDF]
, 2007 Proteins perform a vast number of functional roles. The number of protein structures available for analysis continues to grow and, with the development of methods to predict protein structure directly from genetic sequence without imaging technology, the
Lucas, Craig
core +7 more sources
An artificial immune system for clustering amino acids in the context of protein function classification [PDF]
, 2009 This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon +5 more
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Functional Residues in Proteins [PDF]
Journal of Amino Acids, 2011 We are delighted to present a special issue on the subject of functional residues of proteins. Finding focused articles within the time frame of a special issue is always challenging, which is further compounded by authors' reluctance in making their contributions to new journals. We have been fortunate enough that some leading researchers in the field
Ahmad, Shandar +3 more
openaire +2 more sources
Microbial Cell Factories, 2020 Porcine growth hormone (pGH) is a class of peptide hormones secreted from the pituitary gland, which can significantly improve growth and feed utilization of pigs. However, it is unstable and volatile in vitro.
Jinbo Deng +12 more
doaj +1 more source
The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2
Metabolites, 2023 Human AKR 7A2 broadly participates in the metabolism of a number of exogenous and endogenous compounds. Azoles are a class of clinically widely used antifungal drugs, which are usually metabolized by CYP 3A4, CYP2C19, and CYP1A1, etc. in vivo.
Wanying Wu +7 more
doaj +1 more source
Functional protein dynamics in a crystal
Biophysical Journal, 2023 Abstract Proteins are molecular machines and to understand how they work, we need to understand how they move. New pump-probe time-resolved X-ray diffraction methods open up ways to initiate and observe protein motions with atomistic detail in crystals on biologically relevant timescales.
Eugene Klyshko +6 more
openaire +5 more sources
Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit
Nature Communications, 2023 Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu +10 more
doaj +1 more source
Functional Evolution of Proteins [PDF]
Proteins: Structure, Function, and Bioinformatics, 2019 AbstractThe functional evolution of proteins advances through gene duplication followed by functional drift, whereas molecular evolution occurs through random mutational events. Over time, protein active‐site structures or functional epitopes remain highly conserved, which enables relationships to be inferred between distant orthologs or paralogs.
Jonathan Catazaro +3 more
openaire +2 more sources
Experimental and Molecular Medicine, 2018 Colorectal cancer: Potential treatment for drug-resistant cases A recently identified small molecule shows promise for tackling resistance to a leading colorectal cancer drug.
Sang-Kyu Lee +11 more
doaj +1 more source
Toxins, 2020 Deoxynivalenol (DON) is a highly abundant mycotoxin that exerts many adverse effects on humans and animals. Much effort has been made to control DON in the past, and bio-transformation has emerged as the most promising method.
Xiaojuan Gao +9 more
doaj +1 more source