Results 1 to 10 of about 156,443 (294)

Intrinsic Disorder as a Biomimetic Design Paradigm [PDF]

Biomimetics
Molecular engineering has traditionally followed a structure–function paradigm based on well-defined, folded architectures. However, intrinsically disordered proteins and regions (IDPs/IDRs) reveal that nature also exploits disorder as a functional ...
Thiago Puccinelli, José Rafael Bordin
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Patterny: A Troupe of Decipherment Helpers for Intrinsic Disorder, Low Complexity and Compositional Bias in Proteins [PDF]

Biomolecules
Intrinsically disordered regions (IDRs) are sometimes considered parts of the ‘dark proteomes’, i.e., protein parts that have been largely under-appreciated, as are the overlapping phenomena of low-complexity or compositionally biased regions (LCRs/CBRs).
Paul M. Harrison
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Rapid prediction and analysis of protein intrinsic disorder [PDF]

Protein Science, 2022
Guy W Dayhoff, Vladimir N Uversky
exaly   +2 more sources

Enrichment patterns of intrinsic disorder in proteins [PDF]

Biophysical Reviews, 2022
Ashwini Patil, Patil Ashwini
exaly   +2 more sources

Shell Disorder Models Detect That Omicron Has Harder Shells with Attenuation but Is Not a Descendant of the Wuhan-Hu-1 SARS-CoV-2

Biomolecules, 2022
Before the SARS-CoV-2 Omicron variant emergence, shell disorder models (SDM) suggested that an attenuated precursor from pangolins may have entered humans in 2017 or earlier.
Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, Vladimir N. Uversky   +3 more
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Coarse-Grained Modeling and Molecular Dynamics Simulations of Ca2+-Calmodulin

Frontiers in Molecular Biosciences, 2021
Calmodulin (CaM) is a calcium-binding protein that transduces signals to downstream proteins through target binding upon calcium binding in a time-dependent manner.
Jules Nde, Jules Nde, Pengzhi Zhang, Jacob C. Ezerski, Wei Lu, Kaitlin Knapp, Peter G. Wolynes, Margaret S. Cheung, Margaret S. Cheung   +8 more
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Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner

Biomolecules, 2021
The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein β-catenin acts as the signal
Ben M. Smith, Pamela J. E. Rowling, Christopher M. Dobson, Laura S. Itzhaki   +3 more
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Integration of Nanometer-Range Label-to-Label Distances and Their Distributions into Modelling Approaches

Biomolecules, 2022
Labelling techniques such as electron paramagnetic resonance spectroscopy and single-molecule fluorescence resonance energy transfer, allow access to distances in the range of tens of angstroms, corresponding to the size of proteins and small to medium ...
Gunnar Jeschke
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Generating Ensembles of Dynamic Misfolding Proteins

Frontiers in Neuroscience, 2022
The early stages of protein misfolding and aggregation involve disordered and partially folded protein conformers that contain a high degree of dynamic disorder.
Theodoros K. Karamanos, Arnout P. Kalverda, Sheena E. Radford   +2 more
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Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain

Biomolecules, 2020
Viral BCL2 proteins (vBCL2s) help to sustain chronic infection of host proteins to inhibit apoptosis and autophagy. However, details of conformational changes in vBCL2s that enable binding to BH3Ds remain unknown.
Arvind Ramanathan, Akash Parvatikar, Srinivas C. Chennubhotla, Yang Mei, Sangita C. Sinha   +4 more
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