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Contextualized Protein-Protein Interactions [PDF]
Patterns, 2021 Summary: Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics ...
Anthony Federico, Stefano Monti
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Methods for detecting protein-protein interactions [PDF]
Molecules and Cells: Protein-protein interaction (PPI) is central to all cellular processes and play critical roles in both normal physiology and disease pathogenesis. In this brief guide, we outline the fundamental principles and widely used methods for PPI detection ...
Seok Chan Cho, Hyun Woo Park
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Progress and Prospects in FRET for the Investigation of Protein–Protein Interactions [PDF]
BiosensorsProtein–protein interactions (PPIs) play a crucial role in various biological processes, including signal transduction, transcriptional regulation, and metabolic pathways.
Yue Zhang +4 more
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Protein–Protein Interactions in Base Excision Repair [PDF]
BiomoleculesThe Base Excision Repair (BER) pathway involves a highly coordinated series of protein–protein interactions that facilitate the recognition, excision, and repair of damaged bases. Key enzymes such as DNA glycosylases, apurinic/apyrimidinic endonuclease 1
Govardhan Rathnaiah, Joann B. Sweasy
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Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A
Nature Communications, 2021 Vpr is a HIV-1 accessory virulence factor that also interacts with the human DNA repair protein hHR23A. Here, the authors present the structure of Vpr in complex with the C-terminal half of hHR23A comprising the XPC-binding and ubiquitin-associated ...
In-Ja L. Byeon +11 more
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Scientific Reports, 2021 Targeted DNA methylation is a technique that aims to methylate cytosines in selected genomic loci. In the most widely used approach a CG-specific DNA methyltransferase (MTase) is fused to a sequence specific DNA binding protein, which binds in the ...
Krystyna Ślaska-Kiss +6 more
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Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines
Biotechnology & Biotechnological Equipment, 2021 In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction
Rumiana Tzoneva +6 more
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HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7
Virology Journal, 2021 Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou +3 more
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Developing a peptide to disrupt cohesin head domain interactions
iScience, 2023 Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias +9 more
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