Results 31 to 40 of about 1,854,444 (262)
High Impact: The Role of Promiscuous Binding Sites in Polypharmacology
Molecules, 2019 The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier +6 more
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MicrobiologyOpen, 2020 Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov +10 more
doaj +1 more source
A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment
Nature Communications, 2022 Encystment is a process that allows free-living and parasitic amoebae to survive in unfavorable environments. Here, Bernard et al. provide detailed insights into the early stages of encystment of Acanthamoeba castellanii by integrating RNA-Seq ...
Clément Bernard +10 more
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Biotechnology & Biotechnological Equipment, 2022 Nonhealing wounds are a common complication in patients suffering from diabetes with hyperglycemia being the most deteriorating factor for this serious pathological condition. Despite the great body of data, the molecular mechanisms by which high glucose
Alexandar Evangelatov +6 more
doaj +1 more source
PEPscan: A Broad Spectrum Approach for the Characterization of Protein-Binder Interactions?
Biomolecules, 2022 In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction.
Angelita Rebollo +2 more
doaj +1 more source
Quenching protein dynamics interferes with HIV capsid maturation
Nature Communications, 2017 The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to ...
Mingzhang Wang +16 more
doaj +1 more source
Antagonists of protein–protein interactions [PDF]
Chemistry & Biology, 2000 Protein-protein interactions are often attractive, but not straightforward, targets for disease therapy. Two strategies for identifying inhibitors of these interactions, peptide phage display and high-throughput screening, have recently shown new promise.
openaire +2 more sources
Protein–Protein Interactions in Translesion Synthesis
Molecules, 2021 Translesion synthesis (TLS) is an error-prone DNA damage tolerance mechanism used by actively replicating cells to copy past DNA lesions and extend the primer strand.
Radha Charan Dash, Kyle Hadden
doaj +1 more source
Scientific Reports, 2017 Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected ...
Wei Li +10 more
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Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid
Molecules, 2017 Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that ...
Benjamin Jenkins +3 more
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