Results 31 to 40 of about 2,913,537 (285)

Interaction of two strongly divergent archaellins stabilizes the structure of the Halorubrum archaellum

MicrobiologyOpen, 2020
Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov, Alexey S. Syutkin, Tessa E. F. Quax, Tatjana N. Melnik, R. Thane Papke, Johann Peter Gogarten, Igor I. Kireev, Alexey K. Surin, Sergei N. Beznosov, Anna V. Galeva, Oleg V. Fedorov   +10 more
doaj   +1 more source

Bigraphical models for protein and membrane interactions [PDF]

, 2009
We present a bigraphical framework suited for modeling biological systems both at protein level and at membrane level. We characterize formally bigraphs corresponding to biologically meaningful systems, and bigraphic rewriting rules representing ...
Davide Grohmann, Gabriel Ciobanu, Giorgio Bacci, Marino Miculan   +3 more
core   +5 more sources

Hyperglycemia attenuates fibroblast contractility via suppression of TβRII receptor modulated α-smooth muscle actin expression

Biotechnology & Biotechnological Equipment, 2022
Nonhealing wounds are a common complication in patients suffering from diabetes with hyperglycemia being the most deteriorating factor for this serious pathological condition. Despite the great body of data, the molecular mechanisms by which high glucose
Alexandar Evangelatov, Georgi Georgiev, Borislav Arabadjiev, Stefan Pankov, Plamen Krastev, Albena Momchilova, Roumen Pankov   +6 more
doaj   +1 more source

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

PEPscan: A Broad Spectrum Approach for the Characterization of Protein-Binder Interactions?

Biomolecules, 2022
In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction.
Angelita Rebollo, Louise Fliedel, Pierre Tuffery   +2 more
doaj   +1 more source

Quenching protein dynamics interferes with HIV capsid maturation

Nature Communications, 2017
The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to ...
Mingzhang Wang, Caitlin M. Quinn, Juan R. Perilla, Huilan Zhang, Randall Shirra Jr., Guangjin Hou, In-Ja Byeon, Christopher L. Suiter, Sherimay Ablan, Emiko Urano, Theodore J. Nitz, Christopher Aiken, Eric O. Freed, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn, Tatyana Polenova   +16 more
doaj   +1 more source

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. [PDF]

, 2015
The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited.
Anna Malovannaya, David H Hawke, Jiadong Wang, Jun Qin, Junjie Chen, Kaestner KH, Rudy Guerra, Wei Li, Wenqi Wang, Xu Li, Yuanxin Xi   +10 more
core   +2 more sources

Protein–Protein Interactions in Translesion Synthesis

Molecules, 2021
Translesion synthesis (TLS) is an error-prone DNA damage tolerance mechanism used by actively replicating cells to copy past DNA lesions and extend the primer strand.
Radha Charan Dash, Kyle Hadden
doaj   +1 more source

SnapShot: Protein-Protein Interaction Networks

Cell, 2011
Methods MethodsYeast two-hybridProtein fragment complementationassayTranscription factor, ubiquitinDehydrofolate reductaseGFP or YFPProtein pairs+ Interacting- NoninteractingInteraction examples- Signaling- Enzyme - substrateInteraction strength-Transient to stableAffinity purification/Mass spectrometryBiochemical purification of affinity-tagged baits ...
Seebacher, Jan, Gavin Perrin, Anne-Claude   +1 more
openaire   +3 more sources

Length, Protein-Protein Interactions, and Complexity

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear.
Albert, Bateman, Bates, Bates, Boeckmann, Carlson, Daan Frenkel, Eisenhaber, Hasty, Hopkins, Jeong, Jeong, Lander, Mewes, Michael W. Deem, Mott, Prost, Rhines, Riddle, Steinmetz, Strausberg, Taison Tan, Uetz, Vishal Gupta, Watts, Waxman, Zhang, Zhang   +27 more
core   +1 more source