Results 31 to 40 of about 7,753,904 (295)
A script to highlight hydrophobicity and charge on protein surfaces [PDF]
, 2015 The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo +12 more
core +2 more sources
Chapter 1. Identification of Cellular Protein–Protein Interactions
, 2020 There are myriad interactions between proteins in the cell. The diversity and dynamics of the interactions make them challenging to chart, and a large variety of methods have been developed to tackle the task.
Sara Bergström Lind +9 more
core +1 more source
MicrobiologyOpen, 2020 Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov +10 more
doaj +1 more source
A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment
Nature Communications, 2022 Encystment is a process that allows free-living and parasitic amoebae to survive in unfavorable environments. Here, Bernard et al. provide detailed insights into the early stages of encystment of Acanthamoeba castellanii by integrating RNA-Seq ...
Clément Bernard +10 more
doaj +1 more source
Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]
, 2007 An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core +1 more source
Biotechnology & Biotechnological Equipment, 2022 Nonhealing wounds are a common complication in patients suffering from diabetes with hyperglycemia being the most deteriorating factor for this serious pathological condition. Despite the great body of data, the molecular mechanisms by which high glucose
Alexandar Evangelatov +6 more
doaj +1 more source
PEPscan: A Broad Spectrum Approach for the Characterization of Protein-Binder Interactions?
Biomolecules, 2022 In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction.
Angelita Rebollo +2 more
doaj +1 more source
Quenching protein dynamics interferes with HIV capsid maturation
Nature Communications, 2017 The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to ...
Mingzhang Wang +16 more
doaj +1 more source
Antagonists of protein–protein interactions [PDF]
Chemistry & Biology, 2000 Protein-protein interactions are often attractive, but not straightforward, targets for disease therapy. Two strategies for identifying inhibitors of these interactions, peptide phage display and high-throughput screening, have recently shown new promise.
openaire +2 more sources
Protein–Protein Interactions in Translesion Synthesis
Molecules, 2021 Translesion synthesis (TLS) is an error-prone DNA damage tolerance mechanism used by actively replicating cells to copy past DNA lesions and extend the primer strand.
Radha Charan Dash, Kyle Hadden
doaj +1 more source