Results 1 to 10 of about 453,253 (113)
Detecting mutually exclusive interactions in protein-protein interaction maps. [PDF]
PLoS ONE, 2012 Comprehensive protein interaction maps can complement genetic and biochemical experiments and allow the formulation of new hypotheses to be tested in the system of interest.
Carmen Sánchez Claros, Anna Tramontano
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PLoS Genetics, 2021 The perturbations of protein-protein interactions (PPIs) were found to be the main cause of cancer. Previous PPI prediction methods which were trained with non-disease general PPI data were not compatible to map the PPI network in cancer.
Jiajun Qiu +4 more
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Protein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis
Frontiers in Plant Science, 2014 The phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response ...
Sarbottam ePiya +4 more
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Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts. [PDF]
PLoS Computational Biology, 2009 The recently proposed concept of molecular connectivity maps enables researchers to integrate experimental measurements of genes, proteins, metabolites, and drug compounds under similar biological conditions.
Jiao Li, Xiaoyan Zhu, Jake Yue Chen
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Recent Advances in Protein Homology Detection Propelled by Inter-Residue Interaction Map Threading
Frontiers in Molecular Biosciences, 2021 Sequence-based protein homology detection has emerged as one of the most sensitive and accurate approaches to protein structure prediction. Despite the success, homology detection remains very challenging for weakly homologous proteins with divergent ...
Sutanu Bhattacharya +4 more
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Identifying Potential Biomarkers in Colorectal Cancer and Developing Non-invasive Diagnostic Models Using Bioinformatics Approaches [PDF]
Avicenna Journal of Medical Biochemistry, 2020 Background: Colorectal cancer (CRC) is one of the most frequent causes of gastrointestinal tumors. Due to the invasiveness of the current diagnostic methods, there is an urgent need to develop non-invasive diagnostic approaches for CRC.
Massoud Saidijam +2 more
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Cost-Effective Mapping of Genetic Interactions in Mammalian Cells
Frontiers in Genetics, 2021 Comprehensive maps of genetic interactions in mammalian cells are daunting to construct because of the large number of potential interactions, ~ 2 × 108 for protein coding genes. We previously used co-inheritance of distant genes from published radiation
Arshad H. Khan, Desmond J. Smith
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Advanced Biomedical Research, 2022 Background: Tenascin-C (TNC) is a large glycoprotein of the extracellular matrix which associated with poor clinical outcomes in several malignancies. TNC over-expression is repeatedly observed in several cancer tissues and promotes several processes in ...
Ilnaz Rahimmanesh +2 more
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Identification of Key Genes and Pathways in Peripheral Blood Mononuclear Cells of Type 1 Diabetes Mellitus by Integrated Bioinformatics Analysis [PDF]
Diabetes & Metabolism Journal, 2022 Background The onset and progression of type 1 diabetes mellitus (T1DM) is closely related to autoimmunity. Effective monitoring of the immune system and developing targeted therapies are frontier fields in T1DM treatment.
Xing Li +6 more
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Frontiers in Physiology, 2020 The arteriovenous fistula (AVF) is the first choice for vascular access for hemodialysis of renal failure patients. Venous remodeling after exposure to high fistula flow is important for AVF to mature but the mechanism underlying remodeling is still ...
Kong Jie +13 more
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