Detecting mutually exclusive interactions in protein-protein interaction maps. [PDF]
PLoS ONE, 2012 Comprehensive protein interaction maps can complement genetic and biochemical experiments and allow the formulation of new hypotheses to be tested in the system of interest.
Carmen Sánchez Claros, Anna Tramontano
doaj +16 more sources
Flexible web-based integration of distributed large-scale human protein interaction maps [PDF]
Journal of Integrative Bioinformatics, 2007 Protein-protein interactions constitute the backbone of many molecular processes. This has motivated the recent construction of several large-scale human protein-protein interaction maps [1-10].
Chaurasia Gautam +5 more
doaj +5 more sources
Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts. [PDF]
PLoS Computational Biology, 2009 The recently proposed concept of molecular connectivity maps enables researchers to integrate experimental measurements of genes, proteins, metabolites, and drug compounds under similar biological conditions.
Jiao Li, Xiaoyan Zhu, Jake Yue Chen
doaj +4 more sources
PLoS Genetics, 2021 The perturbations of protein-protein interactions (PPIs) were found to be the main cause of cancer. Previous PPI prediction methods which were trained with non-disease general PPI data were not compatible to map the PPI network in cancer.
Jiajun Qiu +4 more
doaj +2 more sources
Understanding the impact of Klebsiella pneumoniae K-Antigen based MAPS vaccine design on the immune response in animal models. [PDF]
PLoS PathogensMAPS technology represents an innovative approach for the development of polysaccharide-based vaccines, relying on the affinity interaction between biotin and rhizavidin (rhavi), with potential for enhanced coverage through the incorporation of pathogen ...
Elena Palmieri +11 more
doaj +2 more sources
Toward an understanding of the protein interaction network of the human liver
Molecular Systems Biology, 2011 Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang +37 more
doaj +2 more sources
Identification of Key Genes and Pathways in Peripheral Blood Mononuclear Cells of Type 1 Diabetes Mellitus by Integrated Bioinformatics Analysis [PDF]
Diabetes & Metabolism Journal, 2022 Background The onset and progression of type 1 diabetes mellitus (T1DM) is closely related to autoimmunity. Effective monitoring of the immune system and developing targeted therapies are frontier fields in T1DM treatment.
Xing Li +6 more
doaj +1 more source
Recent Advances in Protein Homology Detection Propelled by Inter-Residue Interaction Map Threading
Frontiers in Molecular Biosciences, 2021 Sequence-based protein homology detection has emerged as one of the most sensitive and accurate approaches to protein structure prediction. Despite the success, homology detection remains very challenging for weakly homologous proteins with divergent ...
Sutanu Bhattacharya +4 more
doaj +1 more source
Identifying Potential Biomarkers in Colorectal Cancer and Developing Non-invasive Diagnostic Models Using Bioinformatics Approaches [PDF]
Avicenna Journal of Medical Biochemistry, 2020 Background: Colorectal cancer (CRC) is one of the most frequent causes of gastrointestinal tumors. Due to the invasiveness of the current diagnostic methods, there is an urgent need to develop non-invasive diagnostic approaches for CRC.
Massoud Saidijam +2 more
doaj +1 more source
Cost-Effective Mapping of Genetic Interactions in Mammalian Cells
Frontiers in Genetics, 2021 Comprehensive maps of genetic interactions in mammalian cells are daunting to construct because of the large number of potential interactions, ~ 2 × 108 for protein coding genes. We previously used co-inheritance of distant genes from published radiation
Arshad H. Khan, Desmond J. Smith
doaj +1 more source