Results 31 to 40 of about 435,247 (293)
Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]
, 2013 Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter +3 more
core +1 more source
Mapping oncogenic protein interactions for precision medicine [PDF]
International Journal of Cancer, 2022 AbstractNormal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein‐protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a
Mehdi Sharifi Tabar +4 more
openaire +2 more sources
Basic and Clinical Neuroscience, 2021 Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.
Mona Zamanian Azodi +3 more
doaj
PLoS Computational Biology, 2021 Crystallography and NMR system (CNS) is currently a widely used method for fragment-free ab initio protein folding from inter-residue distance or contact maps. Despite its widespread use in protein structure prediction, CNS is a decade-old macromolecular
Rahmatullah Roche +2 more
doaj +1 more source
Fundamentals of protein interaction network mapping
Molecular Systems Biology, 2015 Studying protein interaction networks of all proteins in an organism ("interactomes") remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the treatment of human diseases.
Jamie Snider +5 more
openaire +3 more sources
Protein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis
Frontiers in Plant Science, 2014 The phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response ...
Sarbottam ePiya +4 more
doaj +1 more source
Archives of Academic Emergency Medicine, 2021 Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients' plasma proteins have revealed new information about the disease.
Mostafa Rezaei-Tavirani +5 more
doaj +1 more source
Combined approaches to flexible fitting and assessment in virus capsids undergoing conformational change [PDF]
, 2013 Fitting of atomic components into electron cryo-microscopy (cryoEM) density maps is routinely used to understand the structure and function of macromolecular machines.
Shakeel, S. +10 more
core +1 more source
A Partitioned Approach to Protein Interaction Mapping [PDF]
, 2002 This is a brief description of a new program for drawing protein interactions in three-dimensional space. Our program divides nodes into three groups: biconnected subgraph in the center, terminal nodes at the outermost region, and the rest in between them.
Yanga Byun, Euna Jeong, Kyungsook Han
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Drosophila Protein interaction Map (DPiM) [PDF]
Fly, 2012 Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times.
Guruharsha, K.G. +6 more
openaire +4 more sources