Results 31 to 40 of about 434,956 (254)

Drosophila Protein interaction Map (DPiM) [PDF]

Fly, 2012
Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times.
Guruharsha, K.G., Obar, Robert, Mintseris, Julian, Aishwarya, K., Krishnan, R.T., VijayRaghavan, K., Artavanis-Tsakonas, Spyros   +6 more
openaire   +4 more sources

Protein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis

Frontiers in Plant Science, 2014
The phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response ...
Sarbottam ePiya, Sandesh K. Shrestha, Brad eBinder, C. Neal eStewart Jr, Tarek eHewezi   +4 more
doaj   +1 more source

Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach [PDF]

Intestinal Research
Background/Aims Colorectal cancer (CRC) and colorectal polyps are intimately linked, with polyps acting as precursors to CRC. Understanding the molecular mechanisms governing their development is crucial for advancing diagnosis and treatment. Employing a
Mehran Radak, Hossein Fallahi
doaj   +1 more source

Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis

Archives of Academic Emergency Medicine, 2021
Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients' plasma proteins have revealed new information about the disease.
Mostafa Rezaei-Tavirani, Mohammad Rostami Nejad, Babak Arjmand, Sina Rezaei Tavirani, Mohammadreza Razzaghi, Vahid Mansouri   +5 more
doaj   +1 more source

Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development

Basic and Clinical Neuroscience, 2021
Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.
Mona Zamanian Azodi, Mostafa Rezaei Tavirani, Majid Rezaei Tavirani, Mohammad Rostami Nejad   +3 more
doaj  

Nodes with high centrality in protein interaction networks are responsible for driving signaling pathways in diabetic nephropathy [PDF]

PeerJ, 2015
In spite of huge efforts, chronic diseases remain an unresolved problem in medicine. Systems biology could assist to develop more efficient therapies through providing quantitative holistic sights to these complex disorders.
Maryam Abedi, Yousof Gheisari
doaj   +2 more sources

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Three-Dimensional Interaction Homology: Deconstructing Residue–Residue and Residue–Lipid Interactions in Membrane Proteins

Molecules
A method is described to deconstruct the network of hydropathic interactions within and between a protein’s sidechain and its environment into residue-based three-dimensional maps.
Glen E. Kellogg
doaj   +1 more source

The plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum

Plant Direct, 2022
The endoplasmic reticulum (ER) houses sensors that respond to environmental stress and underly plants' adaptative responses. These sensors transduce signals that lead to changes in nuclear gene expression.
Venura Herath, Kaylee Connolly, Anna Roach, Ashish Ausekar, Tracy Persky, Jeanmarie Verchot   +5 more
doaj   +1 more source