Results 21 to 30 of about 434,956 (254)

Comparison of human protein–protein interaction maps [PDF]

Bioinformatics, 2007
AbstractMotivation: Large-scale mappings of protein–protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle
Matthias E. Futschik, Gautam Chaurasia, Hanspeter Herzel   +2 more
openaire   +2 more sources

Protein-protein interaction map for yeast TFIID [PDF]

Nucleic Acids Research, 2003
A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs).
Gayatri, Yatherajam, Lei, Zhang, Susan M, Kraemer, Laurie A, Stargell   +3 more
openaire   +2 more sources

Pan-cancer mapping of differential protein-protein interactions [PDF]

Scientific Reports, 2020
AbstractDeciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers.
Gulfidan, Gizem, Turanli, Beste, Beklen, Hande, Sinha, Raghu, Arga, Kazim Yalcin   +4 more
openaire   +5 more sources

Functional maps of protein complexes from quantitative genetic interaction data.

PLoS Computational Biology, 2008
Recently, a number of advanced screening technologies have allowed for the comprehensive quantification of aggravating and alleviating genetic interactions among gene pairs.
Sourav Bandyopadhyay, Ryan Kelley, Nevan J Krogan, Trey Ideker   +3 more
doaj   +1 more source

Identification of therapeutic target genes with DNA microarray in multiple myeloma cell line treated by IKKβ/NF-κB inhibitor [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To explore the mechanism of resistance to IKKβ inhibitor in multiple myeloma (MM) cells and uncover novel therapeutic targets for MM.METHODS: We downloaded the microarray data (GSE8476) from GEO (Gene Expression Omnibus) database.
Aixia Dou, Zhilun Wang, Jingjie Zhao, Junli Liu, Chengyun Zheng   +4 more
doaj   +1 more source

A Partitioned Approach to Protein Interaction Mapping [PDF]

, 2002
This is a brief description of a new program for drawing protein interactions in three-dimensional space. Our program divides nodes into three groups: biconnected subgraph in the center, terminal nodes at the outermost region, and the rest in between them.
Yanga Byun, Euna Jeong, Kyungsook Han
openaire   +1 more source

Hybridized distance- and contact-based hierarchical structure modeling for folding soluble and membrane proteins.

PLoS Computational Biology, 2021
Crystallography and NMR system (CNS) is currently a widely used method for fragment-free ab initio protein folding from inter-residue distance or contact maps. Despite its widespread use in protein structure prediction, CNS is a decade-old macromolecular
Rahmatullah Roche, Sutanu Bhattacharya, Debswapna Bhattacharya   +2 more
doaj   +1 more source

Comprehensive exploration of JQ1 and GSK2801 targets in breast cancer using network pharmacology and molecular modeling approaches

Computational and Structural Biotechnology Journal, 2023
JQ1 and GSK2801 are bromo domain inhibitors (BDI) known to exhibit enhanced anti-cancer activity when combined with other agents. However, the underlying molecular mechanisms behind such enhanced activity remain unclear.
Nanda Kumar Yellapu, Dong Pei, Emily Nissen, Jeffrey A. Thompson, Devin C. Koestler   +4 more
doaj   +1 more source

Mapping oncogenic protein interactions for precision medicine [PDF]

International Journal of Cancer, 2022
AbstractNormal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein‐protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a
Mehdi Sharifi Tabar, Habib Francis, Dannel Yeo, Charles G. Bailey, John E. J. Rasko   +4 more
openaire   +2 more sources

Fundamentals of protein interaction network mapping

Molecular Systems Biology, 2015
Abstract Studying protein interaction networks of all proteins in an organism (“interactomes”) remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the treatment of human diseases. Over the past two decades, diverse biochemical,
Jamie Snider, Max Kotlyar, Punit Saraon, Zhong Yao, Igor Jurisica, Igor Stagljar   +5 more
openaire   +3 more sources