Results 21 to 30 of about 435,247 (293)

A Map of Interactions between the Proteins of a Retrotransposon [PDF]

Journal of Virology, 1998
ABSTRACTThe yeast two-hybrid system and in vitro binding assays were used to characterize 54 potential interactions between the proteins of Tf1, an LTR-retrotransposon found inSchizosaccharomyces pombe. The Tf1 integrase (IN) protein was found to interact strongly with itself and not with other control proteins.
S J, Steele, H L, Levin
openaire   +2 more sources

Prediction of Coffee Effects in Rats with Healthy and NAFLD Conditions Based on Protein-Protein Interaction Network Analysis [PDF]

Research Journal of Pharmacognosy, 2019
Background and objectives: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition. On the other hand, coffee consumption has shown promising for gastrointestinal diseases.
Majid Rezaei-Tavirani, Mostafa Rezaei Tavirani, Mona Zamanian Azodi*, Zahra Akbari, Homa Hajimehdipoor   +4 more
doaj   +1 more source

Evolutionarily conserved herpesviral protein interaction networks. [PDF]

, 2009
Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and causing a variety of different diseases. They possess dsDNA genomes ranging from 120 to 240 kbp encoding between 70 to 170 open reading frames. We previously reported
Bandyopadhyay, Sourav, Baiker Armin, Brunn, Albrecht von, Dong, Yu-An, Silpa Suthram, Haas, Jürgen, Dietlind Rose, von Brunn, Albrecht, Rutenberg Christiane, Ralf Zimmer, Bailer Susanne M., Schmidt, Tina, Stellberger Thorsten, Rose, Dietlind, Haas Jürgen, Titz Björn, Zimmer, Ralf, Christine Zeretzke, Mareike Uhlmann, Seesandra V Rajagopala, Manfred Koegl, Boulet Hélène, Koegl, Manfred, Susanne M Bailer, Trey Ideker, Baiker, Armin, Fossum, Even, Zeretzke, Christine, Peter Uetz, Schmidt Tina, Koegl Manfred, Thorsten Stellberger, Hélène Boulet, Kraus Theo, Armin Baiker, Tina Schmidt, Ideker, Trey, Koszinowski, Ulrich, Sourav Bandyopadhyay, Suthram Silpa, Björn Titz, Boulet, Hélène, Koszinowski Ulrich, Rajagopala, Seesandra V., Caroline C Friedel, Bailer, Susanne M, Rajagopala, Seesandra V, Dong Yu-An, Even Fossum, Bandyopadhyay Sourav, Bailer, Susanne M., Uhlmann, Mareike, Haas, Jürgen G., Ulrich Koszinowski, Uhlmann Mareike, Uetz Peter, Zimmer Ralf, Christiane Rutenberg, Friedel, Caroline C., Friedel, Caroline C, Titz, Björn, Koszinowski, Ulrich H., Rajagopala Seesandra V., Titz, Bjoern, Haas, Juergen, Ideker Trey, Albrecht von Brunn, Suthram, Silpa, Zeretzke Christine, Rutenberg, Christiane, Kraus, Theo, Jürgen Haas, Friedel Caroline C., Stellberger, Thorsten, Theo Kraus, Yu-An Dong, Rose Dietlind, Fossum Even, Uetz, Peter, von Brunn Albrecht   +79 more
core   +1 more source

Protein-protein interaction map for yeast TFIID [PDF]

Nucleic Acids Research, 2003
A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs).
Gayatri, Yatherajam, Lei, Zhang, Susan M, Kraemer, Laurie A, Stargell   +3 more
openaire   +2 more sources

Pan-cancer mapping of differential protein-protein interactions [PDF]

Scientific Reports, 2020
AbstractDeciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers.
Gulfidan, Gizem, Turanli, Beste, Beklen, Hande, Sinha, Raghu, Arga, Kazim Yalcin   +4 more
openaire   +5 more sources

Improving Protein–Ligand Interaction Modeling with cryo-EM Data, Templates, and Deep Learning in 2021 Ligand Model Challenge

Biomolecules, 2023
Elucidating protein–ligand interaction is crucial for studying the function of proteins and compounds in an organism and critical for drug discovery and design.
Nabin Giri, Jianlin Cheng
doaj   +1 more source

Functional maps of protein complexes from quantitative genetic interaction data.

PLoS Computational Biology, 2008
Recently, a number of advanced screening technologies have allowed for the comprehensive quantification of aggravating and alleviating genetic interactions among gene pairs.
Sourav Bandyopadhyay, Ryan Kelley, Nevan J Krogan, Trey Ideker   +3 more
doaj   +1 more source

Deconvolution of Targeted Protein–Protein Interaction Maps

, 2016
Current proteomic techniques allow researchers to analyze chosen biological pathways or an ensemble of related protein complexes at a global level via the measure of physical protein–protein interactions by affinity purification mass spectrometry (AP-MS).
Alexey Stukalov (207069), Giulio Superti-Furga (207094), Jacques Colinge (207092)   +2 more
core   +3 more sources

Identification of therapeutic target genes with DNA microarray in multiple myeloma cell line treated by IKKβ/NF-κB inhibitor [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To explore the mechanism of resistance to IKKβ inhibitor in multiple myeloma (MM) cells and uncover novel therapeutic targets for MM.METHODS: We downloaded the microarray data (GSE8476) from GEO (Gene Expression Omnibus) database.
Aixia Dou, Zhilun Wang, Jingjie Zhao, Junli Liu, Chengyun Zheng   +4 more
doaj   +1 more source

Comprehensive exploration of JQ1 and GSK2801 targets in breast cancer using network pharmacology and molecular modeling approaches

Computational and Structural Biotechnology Journal, 2023
JQ1 and GSK2801 are bromo domain inhibitors (BDI) known to exhibit enhanced anti-cancer activity when combined with other agents. However, the underlying molecular mechanisms behind such enhanced activity remain unclear.
Nanda Kumar Yellapu, Dong Pei, Emily Nissen, Jeffrey A. Thompson, Devin C. Koestler   +4 more
doaj   +1 more source