Results 21 to 30 of about 453,402 (256)
Functional maps of protein complexes from quantitative genetic interaction data.
PLoS Computational Biology, 2008 Recently, a number of advanced screening technologies have allowed for the comprehensive quantification of aggravating and alleviating genetic interactions among gene pairs.
Sourav Bandyopadhyay +3 more
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Identification of therapeutic target genes with DNA microarray in multiple myeloma cell line treated by IKKβ/NF-κB inhibitor [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To explore the mechanism of resistance to IKKβ inhibitor in multiple myeloma (MM) cells and uncover novel therapeutic targets for MM.METHODS: We downloaded the microarray data (GSE8476) from GEO (Gene Expression Omnibus) database.
Aixia Dou +4 more
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Computational and Structural Biotechnology Journal, 2023 JQ1 and GSK2801 are bromo domain inhibitors (BDI) known to exhibit enhanced anti-cancer activity when combined with other agents. However, the underlying molecular mechanisms behind such enhanced activity remain unclear.
Nanda Kumar Yellapu +4 more
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A Partitioned Approach to Protein Interaction Mapping [PDF]
, 2002 This is a brief description of a new program for drawing protein interactions in three-dimensional space. Our program divides nodes into three groups: biconnected subgraph in the center, terminal nodes at the outermost region, and the rest in between them.
Yanga Byun, Euna Jeong, Kyungsook Han
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Flexible web-based integration of distributed large-scale human protein interaction maps
Journal of Integrative Bioinformatics, 2007 Protein-protein interactions constitute the backbone of many molecular processes. This has motivated the recent construction of several large-scale human protein-protein interaction maps [1-10].
Chaurasia Gautam +5 more
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PLoS Computational Biology, 2021 Crystallography and NMR system (CNS) is currently a widely used method for fragment-free ab initio protein folding from inter-residue distance or contact maps. Despite its widespread use in protein structure prediction, CNS is a decade-old macromolecular
Rahmatullah Roche +2 more
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Mapping oncogenic protein interactions for precision medicine [PDF]
International Journal of Cancer, 2022 AbstractNormal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein‐protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a
Mehdi Sharifi Tabar +4 more
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Drosophila Protein interaction Map (DPiM) [PDF]
Fly, 2012 Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times.
Guruharsha, K.G. +6 more
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Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach [PDF]
Intestinal ResearchBackground/Aims Colorectal cancer (CRC) and colorectal polyps are intimately linked, with polyps acting as precursors to CRC. Understanding the molecular mechanisms governing their development is crucial for advancing diagnosis and treatment. Employing a
Mehran Radak, Hossein Fallahi
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Fundamentals of protein interaction network mapping
Molecular Systems Biology, 2015 Abstract Studying protein interaction networks of all proteins in an organism (“interactomes”) remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the treatment of human diseases. Over the past two decades, diverse biochemical,
Jamie Snider +5 more
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